[1]周　静,李　智,周　玉,等.宫颈癌组织中 Ep-CAM和 Ki67的表达及临床意义[J].现代检验医学杂志,2019,34(06):24-27.[doi:10.3969 ／ j.issn.1671-7414.2019.06.006]
　ZHOU Jing,LI Zhi,ZHOU Yu,et al.Expression and Clinicd Value of Ep-CAM and Ki67 in the Cervial Carcinoma Tissue[J].Journal of Modern Laboratory Medicine,2019,34(06):24-27.[doi:10.3969 ／ j.issn.1671-7414.2019.06.006]
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宫颈癌组织中 Ep-CAM和 Ki67的表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
24-27
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Expression and Clinicd Value of Ep-CAM and Ki67 in the Cervial Carcinoma Tissue
文章编号:
1671-7414（2019）06-024-04
作者:
周　静1;  李　智2; 周　玉3; 丁文文1; 杨雪琴1
（1. 荆楚理工学院医学院，湖北荆门　448000；2. 湖北省荆门市东宝区人民医院医务部，湖北荆门　448000； 3. 湖北省荆门市第一人民医院医务部，湖北荆门　448000）
Author(s):
ZHOU Jing1; LI Zhi2; ZHOU Yu3;  DING Wen-wen1; YANG Xue-qin1
（1. Medical School of Jingchu Technology University,Hubei Jingmen 448000, China; 2. Medical Department of Jingmen Dongbao People’s Hospital，Hubei Jingmen 448000, China;3. Medical Department of Jingmen First People’s Hospital, Hubei Jingmen 448000, China）
关键词:
上皮细胞黏附分子（Ep-CAM）; 细胞增殖核抗原67（Ki67）; 宫颈癌
分类号:
R737.33；R730.43
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.006
文献标志码:
A
摘要:
目的　探讨上皮细胞黏附分子（epithelial cellular adhesion molecule，Ep-CAM）和细胞增殖核抗原67（Kiel 67，Ki67）在宫颈癌组织中的表达及临床意义。方法　 选取234 例宫颈活检组织，其中宫颈癌组织94 例（浸润性 鳞癌50 例，腺癌44 例），鳞状上皮内病变（squamous intraepithelial lesion，SiL）组织90 例, 其中低级别SiL（low grade squamous intraepithelial lesion，LSiL ）45 例和高级别SiL（high grade squamous intraepithelial lesion，HSiL ）45 例，正常宫颈组织50 例。分别对上述三类组织进行免疫组化，观察Ep-CAM 和Ki67 的表达情况。结果　Ep-CAM 和 Ki67 在宫颈癌组织中的阳性率均为100%，高于LSiL 和正常宫颈组织，差异均有统计学意义（χ2=121.473~144.000，均 P <0.05）；Ep-CAM 在浸润性鳞癌中的高表达率高于腺癌，差异有统计学意义（χ2=4.713，P <0.05），Ep-CAM 和Ki67 在中晚期宫颈癌组织的高表达率高于早期宫颈癌组织，差异均有统计学意义（χ2=7.598~9.760，均P <0.05）。结论　Ep- CAM 和Ki67 可作为宫颈癌较为理想的肿瘤标志物，尤其是Ep-CAM，能够帮助临床明确细胞的性质，评价肿瘤细胞的 增殖状态，同时预测浸润和转移，具有临床应用价值。
Abstract:
Objective　To explore the expression and the clinic evaluation of Ep-CAM(（epithelial cellular adhesion molecule)，Ki67(Kiel 67) in cervix carcinoma tissue. Methods 　234 cases of cervical biopsy tissue were selected, 94 were cervix carcinoma tissue(50 cases for invasive squamous carcinoma, 44 cases for adenocarcinoma), 90 cases SiL(squamous intraepithelial lesion),45 cases were LSiL(low grade squamous intraepithelial lesion),45 cases were HSiL(high grade squamous intraepithelial lesion) and 50 cases normal cervix tissue. Ep-CAM and Ki67 of all the tissues above were tested by immunohistochemical. Results　The positive rate of Ep-CAM, Ki67 in cervix carcinoma were 100%, significantly higher than LSiL and normal cervical tissue(χ2=121.473~144.000，all P <0.05). Ep-CAM displayed the higher high-expression rate in invasive squamous cell carcinoma than adenocarcinoma（χ2=4.713，P <0.05）, and the high-expression rate of Ep-CAM and Ki67 in advanced cervical cancer were significantly than early cervical cancer（χ2=7.598~9.760，P <0.05）. Conclusion　Ep- CAM and Ki67 can be used as effective tumor markers for cervix carcinoma,especially Ep-CAM, can help to identify the nature of cells,evaluate the proliferative status of cancer cells and predict infiltration and metastasis.So they have clinical application value.

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备注/Memo

备注/Memo:
基金项目：荆门市科技局2018 年科研项目( 项目编号：2018YFYB047）；湖北省高等学校优秀中青年科技创新团队项目（项目编号：T201819）。 作者简介: 周静（1981-），女，硕士研究生, 副教授，研究方向为肿瘤病理，E-mail：zhoujing6162@163.com。收稿日期：2019-09-11
更新日期/Last Update: 2019-12-25