[1]康晓嫒,周川平.儿童难治性支原体肺炎患者细胞免疫和体液免疫指标检测价值分析[J].现代检验医学杂志,2019,34(06):138-141.[doi:10.3969 ／ j.issn.1671-7414.2019.06.035]
　KANG Xiao-yuan,ZHOU Chuan-ping.Detection Value of Cellular Immunity and Humoral Immunity in Children with Refractory Mycoplasmal Pneumonia[J].Journal of Modern Laboratory Medicine,2019,34(06):138-141.[doi:10.3969 ／ j.issn.1671-7414.2019.06.035]
点击复制

儿童难治性支原体肺炎患者细胞免疫和体液免疫指标检测价值分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
138-141
栏目:
检验与临床
出版日期:
2019-12-30

文章信息/Info

Title:
Detection Value of Cellular Immunity and Humoral Immunity in Children with Refractory Mycoplasmal Pneumonia
文章编号:
1671-7414（2019）06-138-05
作者:
康晓嫒; 周川平
（汉中市西乡县人民医院，陕西汉中　723500）
Author(s):
KANG Xiao-yuan; ZHOU Chuan-ping
（Hanzhong Xixiang County People’s Hospital, Shaanxi Hanzhong 723500, China）
关键词:
儿童难治性支原体肺炎; 细胞免疫; 体液免疫
分类号:
R375.2；R392.11
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.035
文献标志码:
A
摘要:
目的　探讨儿童难治性支原体肺炎患者细胞免疫和体液免疫指标检测价值。方法　选择2016 年9 月~2018 年 5 月96 例儿童支原体肺炎患者，包括难治性支原体肺炎46 例（研究组），普通支原体肺炎50 例（对照组），检测两组治疗第1，2，3 和5 天以下实验室指标，包括CD3+，CD4+，CD8+，CD4+/CD8+，IgA，IgG，IgM，WBC，hs-CRP， ESR 及D- 二聚体。结果　研究组治疗第1，2，5 天的CD8+ 明显高于对照组（t =3.421，4.523，5.128，P =0.008，0.000， 0.000），治疗第5 天的CD4+ 明显高于对照组（t =6.112，P =0.000）；研究组治疗第3，5 天的IgA 明显高于对照组（t =2.897， 3.452，P =0.038，0.009），治疗第5 天的IgG 明显高于对照组（t =6.102，P =0.000），治疗第2，3，5 天的IgM 明显高于对照组（t =6.332，5.34，4.534，P =0.000，0.000，0.000）；研究组治疗第2，3，5 天的hs-CRP 与ESR 明显高于对照组（t =6.231，5.320，4.534，P =0.000，0.000，0.000），治疗第1，2，3，5 天的D- 二聚体明显高于对照组（t =4.345，5.102，4.832， P =0.000，0.000，0.000）。CD3+，CD4+，CD8+，CD4+/CD8+ 和IgG 与WBC，hs-CRP，ESR 及 D- 二聚体水平均无相关性，IgA 与hs-CRP，D- 二聚体呈正相关（r =0.627，0.681，P =0.005，0.004），IgM 与 D- 二聚体呈正相关（r =0.657， P =0.008）。结论　儿童难治性支原体肺炎患儿存在体液免疫应答反应为主的免疫功能紊乱现象，其中IgA，IgM 可反映病情严重程度，临床上可以作为预防的参考依据。

参考文献/References:

[1]　王翠玲, 张忠浩, 姜丽娜. 急性期血清生化指标在小儿难治性肺炎支原体肺炎中的早期诊断价值分析 [J]. 临床和实验医学杂志, 2018, 17(11):1221-1224. WANG Cuiling, ZHANG Zhonghao, JIANG Lina. Study on the significance of seroblochemical indices in early diagnosis of refractory Mycoplasma pneumoniae pneumonia in pediatric patients[J]. Journal of Clinical and Experimental Medicine, 2018, 17(11): 1221-1224.
[2]　SHIMIZU T , KIDA Y , KUWANO K . Cytoadherence dependent induction of inflammatory responses by Mycoplasma pneumoniae[J]. Immunology, 2011,133(1): 51-61.
[3]　李少存, 黄丽娜, 郭初, 等. 胸片表现与免疫功能状态在难治性肺炎支原体肺炎患儿肺外并发症早期识别中的临床价值[J]. 中国妇幼保健,2018,33(2):341- 344. LI Shaocun, HUANG Lina, GUO Chu, et al. Clinical value of chest radiograph and immune function status in early identification of extrapulmonary complications in children with refractory Mycoplasma pneumoniae pneumonia[J]. Maternal and Child Health Care of China, 2018, 33(2) :341-344.
[4]　MA Weiyin, PENG Shao, ZHANG Ting Changes in serum YKL-40 level and humoral immune function and their significance in children with recurrent pneumonia].[J]. Chinese Journul of Contemporary Pediatrics, 2017, 19(4):425-429.
[5]　中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童社区获得性肺炎管理指南(2013 修订)( 下)[J]. 中华儿科杂志, 2013, 51(11):745-752. Respiratory group, Pediatrics Branch, Chinese Medical Association, Editorial Board of Chinese Journal of Pediatrics. Guidelines for the management of community acquired pneumonia (2013 Revision) (below) [J]. Chinese Journal of Pediatrics, 2013, 51(11): 745-752.
[6]　孟洪, 李然, 尹小梅, 等. 凝血指标、血小板参数及体液免疫功能检测在儿童重症肺炎中的应用价值 [J]. 血栓与止血学, 2018, 24(6):178-180. MENG Hong, LI Ran, YIN Xiaomei, et al. Application value of coagulation index, platelet parameters and humoral immune function in children with severe pneumonia [J]. Chinese Journal of Thrombosis and Hemostasis, 2018, 24(6): 1072-1074 .
[7]　吴小磊, 张慧玉, 戴秀华, 等. 难治性肺炎支原体肺炎患儿支气管肺泡灌洗液中IL-4 及INF-γ 水平的临床分析[J]. 中国实验诊断学, 2014,18(10):1704- 1705. WU Xiaolei, ZHANG Huiyu, DAI Xiuhua, et al. Clinical analysis of IL-4 and INF-γ levels in bronchoalveolar lavage fluid of children with refractory Mycoplasma pneumoniae pneumonia[J]. Chinese Journal of Laboratory Diagnosis, 2014,18(10): 1704- 1705.
[8]　陈欣, 赵涛, 郭建光, 等. 难治性肺炎支原体肺炎的肺外表现及免疫状态的临床分析[J]. 临床肺科杂志, 2015,20(12):2186-2190. CHEN Xin, ZHAO Tao, GUO Jianguang, et al. Clinical analysis of extrapulmonary manifestations and immune status of refractory Mycoplasma pneumoniae pneumonia [J]. Journal of Clinical Pulmonary Medicine, 2015,20(12):2186-2190.
[9]　施弦, 黄秋玲, 郁峰, 等. 儿童难治性肺炎支原体肺炎血清炎性细胞因子的检测[J]. 中国医学科学院学报, 2013, 35(2):221-223. SHI Xian, HUANG Qiuling, YU Feng, et al. Detection of serum inflammatory cytokines in children with refractory Mycoplasma pneumoniae pneumonia[J]. Journal of Chinese Academy of Medical Sciences, 2013, 35(2):221-223.
[10] 衣楠玲, 刘芳, 李元, 等. 小儿难治性支原体肺炎免疫功能分析[J]. 中国生育健康杂志, 2016, 27(2):159-160. YI Nanling, LIU Fang, LI Yuan, et al. Immunological function analysis of refractory Mycoplasma pneumoniae in children[J]. Chinese Journal of Reproductive Health, 2016, 27(2): 159-160.
[11] 杨丽娟, 许美善, 曹丽芳, 等. 小儿难治性支原体肺炎血清TNF-α、IL-4、IL-10 水平变化及临床意义[J]. 现代生物医学进展, 2017, 17(8):1487-1489. YANG Lijuan, XU Meishan, CAO Lifang, et al. The serum level changes of TNF-α, IL-4 and IL-10 in children with refractory Mycoplasmal pneumoniae pneumonia and its clinical significance[J]. Progress in Modern Biomedicine, 2017, 17(8) :1487-1489,1512.
[12] 梅玉霞, 丁立人, 庄承. 儿童难治性支原体肺炎诊治进展[J]. 上海交通大学学报（医学版）, 2015, 35(2):286-290. MEI Yuxia, DING Liren, ZHUANG Cheng.et al. Progress of diagnosis and treatment of children with refractory Mycoplasmal pneumoniae[J]. Journal of Shanghai Jiaotong University（Medical Science）, 2015, 35(2): 286-290.
[13] 王红连, 徐进. 儿童难治性肺炎支原体肺炎危险因素及支原体耐药的相关性分析[J]. 临床肺科杂志, 2016, 21(4):678-681. WANG Honglian, XU Jin. Study or risk factors of refractory Mycoplasmal pneumoniae pneumonla in children and drug resistance of mycoplasma[J]. Journal of Clinical Pulmonary Medicine, 2016, 21(4): 678-681.
[14] 张琼, 胡晓玲, 沈艺, 等. 肺炎支原体患儿外周血单核细胞Toll 样受体4、肿瘤坏死因子受体相关因子 6、白细胞介素1β 的表达水平及临床意义[J]. 中国妇幼保健,2018,33(15):3472-3475. ZHANG Qiong, HU Xiaoling, SHEN Yi, et al. Expression levels of Toll-like receptor 4, tumor necrosis factor receptor-related factor 6, and interleukin-1β in peripheral blood mononuclear cells of children with Mycoplasma pneumoniae [J]. Maternal and Child Health Care of China, 2018, 33 (15): 3472-3475.
[15] 刘金荣, 赵顺英. 难治性肺炎支原体肺炎判断与药物治疗[J]. 中国实用儿科杂志, 2013,28(12):881-883. LIU Jinrong, ZHAO Shunying. Judgment and drug treatment of refractory Mycoplasmal pneumoniae pneumonia[J]. Chinese Journal of Practical Pediatrics, 2013,28(12):881-883.

相似文献/References:

[1]李涤蓉,赵 蓉,石亚玲,等.疟疾患者外周血T 淋巴细胞亚群检测及临床意义[J].现代检验医学杂志,2023,38(02):186.[doi:10.3969/j.issn.1671-7414.2023.02.035 ]
　Department of Clinical Laboratory,the Eighth Peoples Hospital of Guangzhou Medical University,Guangzhou000,et al.LI Di-rong, ZHAO Rong, SHI Ya-ling ,LIU Yan-xia, JIANG Hong-ya, FAN Ying-min[J].Journal of Modern Laboratory Medicine,2023,38(06):186.[doi:10.3969/j.issn.1671-7414.2023.02.035 ]

备注/Memo

备注/Memo:
作者简介：康晓嫒，女，本科学历，主管检验师，主要研究方向：免疫、血液，E-mail:kangxiaoyuan@163.com。通讯作者：周川平，女，本科学历，主管检验师。收稿日期：2019-06-10
更新日期/Last Update: 2019-12-25