[1]陈 霏,王 碧.血清PDGF 及SDF-1 水平与急性脑梗死患者脑侧支循环建立的相关性研究[J].现代检验医学杂志,2020,35(01):82-85.[doi:10.3969/j.issn.1671-7414.2020.01.022]
　CHEN Fei,WANG Bi.Study on the Correlation between Levels of MMP-9 and SDF-1 in Serumand the Establishment of Cerebral Collateral Circulation inPatients with Acute Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2020,35(01):82-85.[doi:10.3969/j.issn.1671-7414.2020.01.022]
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血清PDGF 及SDF-1 水平与急性脑梗死患者脑侧支循环建立的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
82-85
栏目:
论　　著
出版日期:
2020-02-29

文章信息/Info

Title:
Study on the Correlation between Levels of MMP-9 and SDF-1 in Serum and the Establishment of Cerebral Collateral Circulation in Patients with Acute Cerebral Infarction
文章编号:
1671-7414(2020)01-082-04
作者:
陈 霏;  王 碧
(陕西省核工业二一五医院检验科,陕西咸阳 712000)
Author(s):
CHEN Fei;  WANG Bi
(Department of Clinical Laboratory, 215 Hospital of Nuclear Industry of Shaanxi Province,Shaanxi Xianyang 712000,China)
关键词:
急性脑梗死;  脑侧支循环;  美国国立卫生研究院卒中量表(NIHSS)评分;  梗死体积;  血小板源性生长因子;  基质细胞衍生因子-1
分类号:
R743; R392.11
DOI:
10.3969/j.issn.1671-7414.2020.01.022
文献标志码:
A
摘要:
目的 探讨血清血小板源性生长因子(platelet-derived growth factor,PDGF)及基质细胞衍生因子-1(stromal-derived factor-1,SDF-1)水平与急性脑梗死患者脑侧支循环建立的相关性。方法 选择2017年3月～2019年3月在陕西省核工业二一五医院神经内科住院治疗的82例急性脑梗死患者作为研究对象,依据脑血管造影检查对患者脑侧支循环状态的评估分级分为侧支循环良好组(Fine collateral circulation,FCC组)50例和侧支循环不良组(poor collateral circulation,PCC组)32例,选择35例同期体检健康者作为对照组。采用罗氏MODULARP800全自动生化分析仪检测空腹血糖、血清总胆固醇(total cholesterol,TC)及三酰甘油(triglyceride,TG)水平。血清PDGF及SDF-1水平采用酶联免疫吸附法检测,通过磁共振成像(magnetic resonance imaging,MRI)检查得到患者的梗死体积,依据美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale Score,NIHSS)评价患者入院时的神经功能状态(NIHSS评分),比较分析以上指标的变化与急性脑梗死后脑侧支循环建立的相关性。结果 在对照组、FCC组和PCC组中,血清PDGF(pg/ml)和SDF-1(pg/ml)水平分别为163.20±33.19,127.21±27.32,62.37±13.56和596.32±102.37,965.29±323.17,1 231.37±423.67。FCC组和PCC组的SDF-1水平与对照组比较明显增加,其中PCC组SDF-1水平增高更显著,差异均有统计学意义(F=98.67,P=0.000)。FCC组和PCC组的PDGF水平与对照组比较明显降低,其中PCC组的PDGF水平降低更显著,差异有统计学意义(F=65.23, P=0.000)。在对照组、FCC组和PCC组中,收缩压(mmHg)、空腹血糖(mmol/ml)、TC(mmol/ml)及TG(mmol/ml)水平分别为118.23±13.46,147.06±15.19,153.79±16.57; 4.92±0.97,6.33±1.10,6.51±1.23; 4.23±0.57,4.49±0.67,4.46±0.70和1.29±0.37,1.33±0.36,1.42±0.41。在FCC组和PCC组中,NHISS评分(分)和梗死体积(cm3)分别为11.49±5.27,26.75±9.37和6.39±5.03,11.07±7.96。FCC组和PCC组的收缩压和空腹血糖水平与对照组比较显著增加,差异有统计学意义(F=69.32,29.26,均P=0.000 ),而FCC组和PCC组间的收缩压和空腹血糖水平比较差异无统计学意义(P>0.05)。对照组、FCC组和PCC组间的TC和TG水平比较差异无统计学意义(F=0.37～0.97,均P=1.000)。PCC组的NHISS评分及梗死体积显著高于FCC组(t=43.20～63.27,均P=0.000)。在FCC组和PCC组中,血清PDGF和SDF-1水平呈负相关性(r=-0.802,-0.826,均P<0.01)。在PCC组和FCC组中,PDGF水平分别与NHISS评分和梗死体积呈负相关性,而SDF-1水平分别与NHISS评分和梗死体积呈正相关性(rPDGF=-0.839,-0.847,均P<0.01; rSDF-1=0.818,0.837,均P<0.01)。结论 分析PDGF和SDF-1与急性脑梗死患者脑侧支循环建立的相关性可以预测侧支循环的发生,评价脑梗死的病情进展,并为脑梗死的诊治研究提供新的线索。
Abstract:
Objective To investigate the correlation between levels(platelet-derived growth factor,PDGF)and stromal-derived factor-1(SDF-1)in serum and the establishment of collateral circulation in patients with acute cerebral infarction. Methods 82 patients with acute ischemic stroke hospitalized in Department of Neurology in 215 Hospital of Nuclear Industry of Shaanxi Province from March 2017 to March 2019 were selected as the study subjects. According to the evaluation classification of cerebral collateral circulationby by cerebral angiography, the patients were divided into two groups: fine collateral circulation(FCC,50 cases)group and poor collateral circulation(PCC,32 cases)group, 35 healthy subjects were enrolled in the control group.The levels of fasting blood glucose, total cholesterol(TC)and triglyceride(TG)were measured by Roche modularp800 automatic biochemical analyzer.Serum levels of PDGF and SDF-1 were detected by ELISA. The infarct volume was obtained by magnetic resonance imaging(MRI). The NIHSS score was evaluated by the National Institutes of Health Stroke Scale(NIHSS).The correlation between the changes of the above indexes and the establishment of cerebral collateral circulation after acute cerebral infarction was compared and analyzed. Results The serum levels of PDGF(pg/ml)and SDF-1(pg/ml)in the control group, FCC group and PCC group were 163.20±33.19, 127.21±27.32,62.37±13.56 and 596.32±102.37,965.29±323.17, 1 231.37±423.67,respectively.Compared with the control group, the levels of SDF-1 and PDGF in FCC group and PCC group increased significantly, while the levels of PDGF decreased significantly. The levels of SDF-1 and PDGF in PCC group increased or decreased more significantly(F=65.23,98.67,all P=0.000).In the control group, FCC group and PCC group, the levels of systolic systolic blood pressure(mmHg), fasting blood glucose(mmol/ml), TC(mmol/ml)and TG(mmol/ml)were 118.23±13.46,147.06±15.19 and 153.79±16.57, 4.92±0.97,6.33±1.10 and 6.51±1.23, 4.23±0.57, 4.49±0.67,4.46±0.70 and 1.29±0.37,1.33±0.36,1.42±0.41,resperctively. In FCC and PCC groups, NIHSS score(points)and infarct volume(cm3)were 11.49±5.27,26.75±9.37 and 6.39±5.03,11.07±7.96, respectively.The levels of systolic blood pressure and fasting blood glucose increased significantly in FCC group and PCC group compared with in the control group,the difference was statistically significant(F=69.32,29.26, all P=0.000), which between FCC Group and PCC group were not statistically significant(P>0.05).There were no significant differences in the levels of TC and TG between FCC Group and PCC group(F=0.37～0.97,all P=1.000). The NHISS score and infarct volume in PCC group were significantly higher than those in FCC Group(t=43.20～63.27,all P=0.000). In FCC group and PCC group, serum levels of PDGF and SDF-1 were negatively correlated(r=-0.802,-0.826,P<0.01). In PCC and FCC groups, PDGF levels were negatively correlated with NHISS scores and infarct volume at admission, while SDF-1 levels were positively correlated with NHISS scores and infarct volume at admission,respectively(rPDGF=-0.839,-0.847,P<0.01; rSDF-1=0.818,0.837,P<0.01). Conclusion Analysis of the correlation between the two markers(PDGF and SDF-1)and the establishment of cerebral collateral circulation in patients with acute cerebral infarction can predict the occurrence of collateral circulation and evaluate cerebral infarction.It also provides new clues for the diagnosis and treatment of cerebral infarction.

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备注/Memo

备注/Memo:
作者简介:陈霏(1985-),女,大学本科,主管检验师,研究方向:脑卒中的实验室诊断,E-mail:3432936789@qq.com。 通讯作者:王碧(1984-),女,大学本科,主管检验师,研究方向:脑卒中的实验室诊断,E-mail:3435077084@qq.com。收稿日期:2019-10-13 修回日期:2019-10-29
更新日期/Last Update: 2020-03-30