[1]郭 燕,贺 晨,段 勇,等.无偿献血者ALT 水平异常与HBI,OBI,HCI 和OCI 的相关性研究[J].现代检验医学杂志,2020,35(02):18-21.[doi:10.3969/j.issn.1671-7414.2020.02.006]
 GUO Yan,HE Chen,DUAN Yong,et al.Investigating the Correlation of Abnormal ALT Level andHBI, OBI, HCI, OCI in Volunteer Blood Donors[J].Journal of Modern Laboratory Medicine,2020,35(02):18-21.[doi:10.3969/j.issn.1671-7414.2020.02.006]
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无偿献血者ALT 水平异常与HBI,OBI,HCI 和OCI 的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
18-21
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Investigating the Correlation of Abnormal ALT Level andHBI, OBI, HCI, OCI in Volunteer Blood Donors
文章编号:
1671-7414(2020)02-018-04
作者:
郭 燕贺 晨段 勇现红斌张 欢李 锦
(陕西省血液中心,西安 710061)
Author(s):
GUO Yan HE Chen DUAN Yong XIAN Hong-bin ZHANG Huan LI Jin
(Shaanxi Blood Center, Xi’an 710061, China)
关键词:
无偿献血者丙氨酸氨基转移酶乙型肝炎病毒感染丙型肝炎病毒感染隐匿性乙型肝炎病毒感染隐匿性丙型肝炎病毒感染
分类号:
R457.12
DOI:
10.3969/j.issn.1671-7414.2020.02.006
文献标志码:
A
摘要:
目的 探讨无偿献血人群丙氨酸氨基转移酶(alanine aminotransferase,ALT)水平异常与乙型肝炎病毒感染(hepatitis B virus infection,HBI),隐匿性乙型肝炎病毒感染(occult hepatitis B virus infection,OBI),丙型肝炎病毒感染(hepatitis C virus infection,HCI),隐匿性丙型肝炎病毒感染(occult hepatitis C virus infection,OCI)的相关性。方法 分析陕西省血液中心2019 年1~6 月98 697 份血液标本ALT,HBV,HCV 检测结果;对其中ALT 单项异常标本进行核酸检测(nucleic acid testing,NAT)。此外,收集ALT 初筛不合格血样125 份,合格血样112 份,实验室检测ALT,HBsAg 和抗-HCV,分离外周血淋巴细胞(peripheral blood mononuclear cells,PBMCs)并检测HCV RNA。结果 98 697 份血液标本中ALT 水平异常者654 份,其中ALT 单项异常者641 份,ALT 合并HBsAg/ 抗-HCV 阳性8 份,仅占ALT 异常者的1.22%;HBsAg 阳性组,抗-HCV 阳性组与对应阴性组的ALT 异常率差异无统计学意义(P > 0.05);ALT 初筛不合格者HBV,HCV 感染率高于ALT 初筛合格者(4.8% vs 0.86%)和ALT 复检不合格者(4.8% vs 1.22%),差异有统计学意义(χ2=22.78,7.61,均P < 0.05);641 份ALT 单项异常者NAT 检测发现HBV DNA 阳性一例;ALT初筛不合格血样中的119 例ALT 单项异常者检出OCI 一例,112 例合格献血者未检出OCI。结论 ALT 筛查献血者OBI,HBI,HCI 及窗口期的意义并不大,ALT 对OCI 筛查有一定意义。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划(2015JM8393)。作者简介:郭燕(1980-),女,医学博士,副主任技师,主要从事输血医学相关研究,E-mail: 20524988@qq.com。通讯作者:李锦(1972-),女,理学硕士,副主任技师,主要从事输血医学相关研究,E-mail: 1105416391@qq.com。收稿日期:2020-01-06修回日期:2020-01-30
更新日期/Last Update: 2020-04-30