[1]王琳琳a,张晓凝,王刚b,等.外周血白细胞参数对于新型冠状病毒肺炎诊断的临床意义[J].现代检验医学杂志,2020,35(05):110-112,146.[doi:10.3969/j.issn.1671-7414.2020.05.028]
　WANG Lin-lina,ZHANG Xiao-ning,WANG Gangb,et al.Clinical Significance of Peripheral Blood Leukocyte Parameters in the Diagnosis of COVID-19[J].Journal of Modern Laboratory Medicine,2020,35(05):110-112,146.[doi:10.3969/j.issn.1671-7414.2020.05.028]
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外周血白细胞参数对于新型冠状病毒肺炎诊断的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
110-112,146
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2020-11-01

文章信息/Info

Title:
Clinical Significance of Peripheral Blood Leukocyte Parameters in the Diagnosis of COVID-19
文章编号:
1671-7414（2020）05-110-04
作者:
王琳琳1a; 张晓凝2; 王刚1b; 丁燕3; 马兴丽1
1. 天津市西青医院a. 医学检验科；b. 骨一科，天津 300380；2. 德州市立医院，山东德州 253012； 3. 德州市武城县人民医院，山东武城 253300
Author(s):
WANG Lin-lin1a;  ZHANG Xiao-ning2;  WANG Gang1b;  DING Yan3;  MA Xing-li1
1a.Department of Clinical Laboratory；1b.Department of Orthopaedics, Xiqing Hospital of Tianjin City,Tianjin 300380,China; 2. Dezhou Municipal Hospital ,Shandong Dezhou 253012, China; 3.Wucheng County People’s Hospital of Dezhou City, Shandong Wucheng 253300,China
关键词:
新型冠状病毒肺炎; 外周血; 血细胞检测; 白细胞参数
分类号:
R373.19；R446.111
DOI:
10.3969/j.issn.1671-7414.2020.05.028
文献标志码:
A
摘要:
目的　探讨外周血白细胞参数中白细胞（white blood Cell，WBC）计数、中性粒细胞（neutrophil，Neu）计数、 淋巴细胞（lymphocyte，Lym）计数以及中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）在新型冠 状病毒肺炎（COVID-19）诊断中的临床意义。方法　收集天津市西青医院2019 年10 月~2020 年3 月健康查体人群28 例为健康组，同期该院甲流患者28 例为甲流组，京津冀鲁地区COVID-19 确诊患者28 例为新冠组，均采用流式细胞计 数法进行血细胞检测，使用Graphpad Prism 统计学软件分析三组人群的WBC 计数、Neu 计数、Lym 计数、NLR 值差 异性及COVID-19 患者年龄与NLR 值的相关性。结果　新冠组患者外周血中WBC（q=6.048, P<0.05）计数，Neu（q=5.696, P<0.05）计数及NLR 值（q=2.811, P<0.05）均低于甲流组，差异均具有统计学意义。Lym 计数（q=7.898, P<0.05）低于 健康组而NLR 值（q=4.159, P<0.05）高于健康组，差异具有统计学意义，新冠组中＜ 50 岁患者与≥ 50 岁患者的NLR 值差异具有统计学意义（t=2.204, P<0.05）。结论　外周血血细胞检测中WBC 计数、Neu 计数、Lym 计数及NLR 值指 标可用于辅助鉴别COVID-19 患者、甲流患者、健康人群，对COVID-19 诊断有一定临床意义，且新冠患者NLR 值具 有年龄差异性。
Abstract:
Objective　To investigate the clinical significance of peripheral blood white blood cell (WBC) count, neutrophil (Neu) count, lymphocyte (Lym) count, and neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of COVID-19. Methods　A total of 28 health check-up patients were collected as health group from Tianjin Xiqing Hospital from October 2019 to March 2020,and at the same time, 28 cases of patients with influenza A in the hospital were in the group of A-flu, and 28 patients confirmed COVID-19 in Beijing-Tianjin-Hebei-Shandong regions as COVID-19 group. They were given bloodroutine tests performed by flow cytometry. Statistical software Graphpad Prism was used to analyze the differences of WBC count, Neu count, Lym count and NLR value among three groups, and the correlation between age and NLR value of patients with COVID-19. Results　The WBC count (q=6.048,P< 0.05), Neu count(q=5.696,P<0.05), and NLR value(q=2.811,P< 0.05) in peripheral blood of COVID-19 group were lower than those in the H1N1 group, and the differences were statistically significant, Lym count(q=7.898,P < 0.05) was lower than that of the healthy group, while NLR value (q =4.159,P< 0.05) was higher than that of the healthy group, and the difference was statistically significant. The NLR values of patients ＜ 50 years old and ≥ 50 years old in the COVID-19 group was significantly different (t=2.204,P< 0.05). Conclusion　The WBC count, Neucount, Lym countand NLR valueindexes in peripheral blood routine test can be used to help distinguish COVID-19 patients, H1N1 patients and healthy population, which has certain clinical significance for the diagnosis of COVID-19. Moreover, NLR value of COVID-19 patients has age difference.

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备注/Memo

备注/Memo:
作者简介：王琳琳（1989-），女，本科，检验技师，研究方向：临床检验、微生物检验,E-mail：781849458@qq.com。
通讯作者：马兴丽（1977-），女，主管技师，E-mail：xinglizixin@yeah.net。
更新日期/Last Update: 2020-10-30