[1]付忠晓,黄 俊,王长征,等.COVID-19患者血浆凝血指标及D-二聚体水平检测对临床分型的鉴别价值[J].现代检验医学杂志,2021,36(02):118-121.[doi:doi:10.3969/j.issn.1671-7414.2021.02.028]
 FU Zhong-xiao,HUANG Jun,WANG Chang-zheng,et al.Preliminary Study on the Differential Value of Coagulation Indexes and D-dimer Level in the Clinical Classification of COVID-19 Patient[J].Journal of Modern Laboratory Medicine,2021,36(02):118-121.[doi:doi:10.3969/j.issn.1671-7414.2021.02.028]
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COVID-19患者血浆凝血指标及D-二聚体水平检测对临床分型的鉴别价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
118-121
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2021-04-30

文章信息/Info

Title:
Preliminary Study on the Differential Value of Coagulation Indexes and D-dimer Level in the Clinical Classification of COVID-19 Patient
文章编号:
1671-7414(2021)02-118-05
作者:
付忠晓黄 俊王长征
(华中科技大学同济医学院附属荆州中心医院检验医学部, 湖北荆州 434000)
Author(s):
FU Zhong-xiao HUANG Jun WANG Chang-zheng et al
(Department of Laboratory Medicine, Jingzhou Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Hubei Jingzhou 434000, China)
关键词:
新型冠状病毒肺炎D-二聚体凝血指标临床分型
分类号:
R373.19;R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.028
文献标志码:
A
摘要:
目的 探讨新型冠状病毒肺炎(COVID-19)患者疾病分型中血浆凝血指标及D-二聚体的鉴别价值。方法  选取2020年1月25日~2月24日在荆州市中心医院诊断为COVID-19的52例患者住院期间检查的101份血凝标本,将样本按采血时患者的疾病分期分为轻症(n=31)和重症(n=70)。应用非配对t检验和受试者工作曲线(ROC 曲线)分析探讨凝血指标以及D-二聚体水平与患者疾病严重程度的关系,其中凝血指标包括活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)和血浆纤维蛋白原(Fg)。结果 101份血凝标本中,重症组凝血指标中的APTT,TT和PT以及D-二聚体水平显著高于轻症组,差异均具有统计学意义(P<0.05)。而Fg含量差异无统计学意义(P>0.05)。APTT,TT,PT,D-二聚体,APTT+TT,APTT+PT和TT+PT的ROC曲线下面积(AUC)分别为0.605,0.749,0.760,0.949,0.764,0.758和0.865。结论 单独D-二聚体、凝血指标联合使用对COVID-19疾病分型有很好的诊断价值,可辅助临床诊疗,进一步推广于临床。

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备注/Memo

备注/Memo:
基金项目:病毒学国家重点实验室2020年度开放基金(2020IOV001)。
作者简介:付忠晓(1990-),女,硕士,主管技师,主要从事病毒感染与免疫方面的研究,E-mail:930370195@qq.com。
通讯作者:邓明凤(1960-),女,主任技师,硕士生导师,E-mail:jzlcb002@163.com。
更新日期/Last Update: 2021-04-10