[1]徐海燕,陆学东.多发性骨髓瘤早期实验诊断相关新兴生物标志物的最新研究进展[J].现代检验医学杂志,2021,36(05):180-183.[doi:10.3969/j.issn.1671-7414.2021.05.039]
 XU Hai-yan,LU Xue-dong.Recent Research Rrogress of Novel Biomarkers for Early ExperimentalDiagnosis of Multiple Myeloma[J].Journal of Modern Laboratory Medicine,2021,36(05):180-183.[doi:10.3969/j.issn.1671-7414.2021.05.039]
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多发性骨髓瘤早期实验诊断相关新兴生物标志物的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年05期
页码:
180-183
栏目:
综 述
出版日期:
2021-10-14

文章信息/Info

Title:
Recent Research Rrogress of Novel Biomarkers for Early ExperimentalDiagnosis of Multiple Myeloma
文章编号:
1671-7414(2021)05-180-04
作者:
徐海燕陆学东
(中山大学附属第八医院医学研究中心,广东深圳 518000)
Author(s):
XU Hai-yan LU Xue-dong
(Medical Research Central, the Eighth Affiliated Hospital, Sun Yat-sen University, Guangdong Shenzhen 518000, China)
关键词:
多发性骨髓瘤生物标志物早期诊断
分类号:
R733.3;R446
DOI:
10.3969/j.issn.1671-7414.2021.05.039
文献标志码:
A
摘要:
多发性骨髓瘤(multiple myeloma, MM)是骨髓中浆细胞恶性增殖并伴有单克隆免疫球蛋白分泌为特点的疾病。传统的MM实验诊断的生物标志物有很多种,但敏感度和特异度较低,MM的生存及预后仍很差。随着研究的进展,一些新的生物标志物被证明可预测早期MM的疾病进展,有利于MM的早期诊断和后续的靶点治疗。该文就近年来发现的一些潜在的MM早期实验诊断相关生物标志物包括骨髓微环境中相关标志蛋白、非编码RNA、循环肿瘤细胞以及循环肿瘤DNA进行综述。
Abstract:
Multiple myeloma (MM) is characterized by malignant proliferation of plasma cells in bone marrow and secretionof monoclonal immunoglobulin. There are many traditional biomarkers for the experimental diagnosis of MM, but they lacksensitivity and specificity, and the survival and prognosis of MM are still poor. With the development of research, some novelbiomarkers have been proved to be able to predict the progression of early MM, which is conducive to the early diagnosis andsubsequent target therapy of MM. This article reviews some potential biomarkers for early experimental diagnosis of MM,including related marker proteins in bone marrow microenvironment, non coding RNA, circulating tumor cells and circulatingtumor DNA.

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备注/Memo

备注/Memo:
作者简介:徐海燕(1993-),女,硕士,初级医师,研究方向:多发性骨髓瘤病理机制研究,E-mail: haiyanxu1206@126.com。
通讯作者:陆学东(1961-),男,研究员,研究方向:医学分子微生物学和免疫学研究,E-mail: luxuedong2004@163.com。
更新日期/Last Update: 1900-01-01