[1]姜永滨,任东铭,隋成君.下肢动脉硬化闭塞症患者血清IL-17 和TNF-α 水平表达及其临床意义[J].现代检验医学杂志,2022,37(05):168-170+185.[doi:10.3969/j.issn.1671-7414.2022.05.033]
　JIANG Yong-bin,REN Dong-ming,SUI Cheng-jun.Expression and Clinical Significance of Serum Levels of IL-17 and TNF-α in Patients with Arteriosclerosis Obliterans of Lower Extremity[J].Journal of Modern Laboratory Medicine,2022,37(05):168-170+185.[doi:10.3969/j.issn.1671-7414.2022.05.033]
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下肢动脉硬化闭塞症患者血清IL-17 和TNF-α 水平表达及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年05期
页码:
168-170+185
栏目:
检验与临床
出版日期:
2022-09-15

文章信息/Info

Title:
Expression and Clinical Significance of Serum Levels of IL-17 and TNF-α in Patients with Arteriosclerosis Obliterans of Lower Extremity
文章编号:
1671-7414（2022）05-168-04
作者:
姜永滨; 任东铭; 隋成君
鞍山市鞍钢总医院介入科，辽宁鞍山 114000
Author(s):
JIANG Yong-bin;  REN Dong-ming;  SUI Cheng-jun
Department of Interventional, Ansteel Group General Hospital of Anshan City, Liaoning Anshan 114000, China
关键词:
下肢动脉硬化闭塞症; 白细胞介素; 肿瘤坏死因子-α
分类号:
R543.5
DOI:
10.3969/j.issn.1671-7414.2022.05.033
文献标志码:
A
摘要:
目的　探讨下肢动脉硬化闭塞症(arteriosclerosis obliterans，ASO) 患者血清白细胞介素（interleukin，IL）-17和肿瘤坏死因子（tumor necrosis factor，TNF）- α 水平检测及临床意义。方法　选取2016 年5 月～ 2020 年1 月于鞍山市鞍钢总医院住院治疗的下肢动脉硬化闭塞症患者90 例为研究对象（病例组），其中正常组78 例，狭窄组12 例；选取同期健康体检者92 例作为对照组。采用Pearson 法分析患者血清IL-17 与TNF-α 的相关性。结果　病例组IL-17（812.94±103.75pg/ml）和TNF-α（74.28±4.96ng/L）高于对照组（421.58±97.46 pg/ml，30.44±2.79ng/L），差异有统计学意义（t=26.235，73.696，均P ＜ 0.05）。下肢动脉硬化闭塞症患者血清IL-17 与TNF-α 呈正相关（r=0.527，P ＜ 0.05）。狭窄组血清IL-17 （894.27±110.34pg/ml）和TNF-α（79.26±3.71ng/L）水平高于正常组（653.29±98.16pg/ml，53.18±2.94ng/L），差异有统计学意义（t=7.790，27.604，均P ＜ 0.05）。结论　下肢动脉硬化闭塞症患者血清IL-17 和TNF-α 明显增高，二者与患者分期及预后均相关，可能共同参与了下肢动脉硬化闭塞症的发生、发展。
Abstract:
Objective　To investigate the serum levels of interleukin (IL)-17 and tumor necrosis factor (TNF) - α in patients with arteriosclerosis obliterans （ASO）of lower extremity and their clinical significance. Methods　From May 2016 to January 2020, 90 patients with ASO in Ansteel Group General Hospital of Anshan City were selected as the research objects (case group), 78 cases in normal group and 12 cases in stenosis group. A total 92 healthy subjects were selected as the control group. Pearson method was used to analyze the correlation between serum IL-17, TNF-α and related indexes in patients with lower extremity ASO. Results　 IL-17 (812.94±103.75 pg/ml ) and TNF-α (74.28±4.96 ng/L) in the case group were higher than those in the control group (421.58±97.46 pg/ml, 30.44±2.79 ng/L), the differences were statistically significant (t=26.235, 73.696, all P ＜ 0.05). There was a positive correlation between serum IL-17 and TNF-α (r=0.527, P<0.05). The levels of serum IL-17 (894.27±110.34pg/ ml) and TNF-α (79.26±3.71ng/L) in the stenosis group were higher than those in the normal group (653.29±98.16 pg/ ml, 53.18±2.94ng/L), and the differences were statistically significant (t=7.790, 27.604, all P<0.05). Conclusion　IL-17 and TNF-α were highly expressed in the serum of patients with lower extremity ASO, and they were related to the stage and prognosis of patients, and may participate in the occurrence and development of ASO of lower limbs.

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备注/Memo

备注/Memo:
作者简介：姜永滨（1981-），男，硕士研究生，副主任医师，研究方向：介入放射（外周血管）方面，E-mail：jyb114000@163.com。
更新日期/Last Update: 2022-09-15