[1]杨 磊a,冯美宁a,宋海锋a,等.COVID-19 患者SARS-CoV-2 感染前后精液质量参数变化的meta 分析[J].现代检验医学杂志,2023,38(01):179-185.[doi:10.3969/j.issn.1671-7414.2023.01.034]
　YANG Leia,FENG Mei-ninga,SONG Hai-fenga,et al.Changes of Semen Quality Parameters before and after SARS-CoV-2 Infection in Patients with COVID-19: A Meta-Analysis[J].Journal of Modern Laboratory Medicine,2023,38(01):179-185.[doi:10.3969/j.issn.1671-7414.2023.01.034]
点击复制

COVID-19 患者SARS-CoV-2 感染前后精液质量参数变化的meta 分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年01期
页码:
179-185
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2023-01-15

文章信息/Info

Title:
Changes of Semen Quality Parameters before and after SARS-CoV-2 Infection in Patients with COVID-19: A Meta-Analysis
文章编号:
1671-7414（2023）01-179-07
作者:
杨 磊a; 冯美宁a; 宋海锋a; 杨 进a; 许 涛b
（咸阳市中心医院a. 生殖医学科；b. 检验科，陕西咸阳 712099）
Author(s):
YANG Leia;  FENG Mei-ninga;  SONG Hai-fenga;  YANG Jina;  XU Taob
(a. Department of Reproductive Medicine; b. Department of Clinical Laboratory, Xianyang Central Hospital, Shaanxi Xianyang 712099, China)
关键词:
新型冠状病毒肺炎; 严重急性呼吸综合征冠状病毒2; 精液质量参数; Meta 分析
分类号:
R373.19；R446.19
DOI:
10.3969/j.issn.1671-7414.2023.01.034
文献标志码:
A
摘要:
目的 分析新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）患者严重急性呼吸综合征冠状病毒2（severeacute respiratory syndrome coronavirus 2,SARS-CoV-2）感染前后精液质量参数的变化。方法 计算机检索PubMed，Embase，中国知网、万方和维普数据库，筛选有关COVID-19 患者SARS-CoV-2 感染前后精液质量参数变化的文献，检索时间为2019 年12 月～ 2022 年8 月5 日。文献质量采用NOS 评分。统计分析采用StataSE15.0 软件，根据SARSCoV-2 感染后精液检测时间进行亚组分析、敏感度分析评估结果的稳定性。结果 纳入6 篇COVID-19 患者SARSCoV-2 感染前后的自身对照文献，样本量为21 ～ 100 例。SARS-CoV-2 感染后精液质量参数与感染前相比，总活动精子率[SMD=-0.73，95%CI（-1.16 ～ -0.30）] 和前向运动精子率[SMD=-0.52，95%CI（-0.87 ～ -0.17）] 下降，差异均有统计学意义（Z=-3.356，-2.932，P=0.001，0.003）。亚组分析显示，SARS-CoV-2 感染三个月后精液质量参数与感染前相比，精液量[SMD=-0.15，95%CI（-0.70 ～ 0.40）]、精子浓度[SMD=-0.15，95%CI（-0.43 ～ 0.13）]、总活动精子率[SMD=-0.85，95%CI（-1.87 ～ 0.18）] 和前向运动精子率[SMD=-0.48，95%CI（-1.13 ～ 0.17）] 差异均无统计学意义（Z=-1.622 ～ -0.522，均P>0.05）。敏感度分析精液参数结果稳定。结论 初步研究发现COVID-19 患者精液质量短期内可能存在不良影响，三个月后可以恢复。
Abstract:
Objective To analyze the changes insemen quality parameters in patients with coronavirus disease 2019 (COVID-19) before and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods PubMed, Embase, China National Knowledge Infrastructure, Wanfang and VIP databases were searched by computer to screen the literature on the changes in semen quality parameters before and after SARS-CoV-2 infection in patients with COVID-19 from December 2019 to August 5, 2022.The quality of the literature was scored by NOS. Statistical analysis was performed using StataSE15.0 software. Subgroup analysis was performed according to the semen testing time after SARS-CoV-2 infection，and sensitivity analysis was performed to assess the stability of the results. Results Six self-control papers of COVID-19 patients before and after SARS-CoV-2 infection were included, with sample sizes ranging from 21 to 100 cases. Semen quality parameters after SARS-CoV-2 infection decreased in total motile sperm rate [SMD=-0.73, 95% CI (-1.16 ～ -0.30)] and forward motile sperm rate [SMD=-0.52, 95% CI (-0.87 ～ -0.17)] compared with pre-infection, the differences were statistically significant (Z= -3.356, -2.932, P=0.001, 0.003). Subgroup analysis showed that the semen volume[SMD=-0.15, 95%CI(-0.70 ～ 0.40)], sperm concentration[SMD=-0.15, 95%CI(-0.43 ～ 0.13)],total motile sperm rate[SMD=-0.85, 95%CI(-1.87 ～ 0.18)] and forward motile sperm rate[SMD=-0.48, 95%CI(-1.13 ～ 0.17)] were not significantly different (Z=-1.622 ～ -0.522, all P>0.05) after 3 months compared to those before SARS-CoV-2 infection. Sensitivity analysis of semen parameters showed stable results. Conclusion Preliminary studies found that sperm quality in COVID-19 patients would be adversely affected in the short term and can recover after 3 months.

参考文献/References:

[1] ZHOU Peng, YANG Xinglou, WANG Xianguang,et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature, 2020,579(7798): 270-273.
[2] WANG Zhengpin, XU Xiaojiang. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, leydig and sertoli cells[J]. Cells, 2020,9(4):920.
[3] LI Diangeng, JIN Meiling, BAO Pengtao, et al.Clinical characteristics and results of semen tests among men with coronavirus disease 2019[J]. JAMA Netw Open, 2020, 3(5):e208292.
[4] GACCI M, COPPI M, BALDI E, et al. Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19 [J]. Human Reproduction, 2021, 36(6): 1520-1529.
[5] ENIKEEV D, TARATKIN M, MOROZOV A, et al.Prospective two-arm study of the testicular function in patients with COVID-19[J]. Andrology, 2022, 10(6):1047-1056.
[6] GUO Tonghang, SANG Meiying, BAI Shun, et al.Semen parameters in men recovered from COVID-19[J]. Asian Journal Andrology, 2021, 23(5): 479-483.
[7] ERBAY G, SANLI A, TUREL H, et al. Short‐term effects of COVID‐19 on semen parameters: A multicenter study of 69 cases[J]. Andrology，2021, 9(4):1060-1065.
[8] GUL A, ZENGIN S, DUNDAR G, et al. Do SARSCoV-2 infection (COVID-19) and the medications administered for its treatment impair testicular functions? [J] .Urologia Intenationalis, 2021, 105(11/12): 944-948.
[9] HAMARAT M B, OZKENT M S, YILMAZ B,et al. Effect of SARS-CoV-2 infection on semen parameters[J]. Canadian Urological Association Journal, 2022, 16(3): E173-E177.
[10] PAZIR Y, EROGLU T, KOSE A, et al. Impaired semen parameters in patients with confirmed SARS-CoV-2 infection: A prospective cohort study[J].Andrologia，2021, 53(9):e14157.
[11] RAFIEE B, BAGHER TABEI S M. The effect of N-acetyl cysteine consumption on men with abnormal sperm parameters due to positive history of COVID-19 in the last three months [J]. Archivio Italiano Urologia Andrologia, 2021, 93(4): 465-467.
[12] KO? E, KESERO?LU B B. Does COVID-19 worsen the semen parameters? Early results of a tertiary healthcare center [J]. Urol Int, 2021, 105(9/10): 743-748.
[13] GHOLAMI M, MOOSAZADEH M, HAGHSHENASH M R, et al. Evaluation of the presence of bacterial and viral agents in the semen of infertile men: a systematic and meta-analysis review study [J]. Front Med(Lausanne), 2022, 9: 835254.
[14] HUANG Fen, LONG Feiyan, YU Wenhai, et al. High prevalence of hepatitis E virus in semen of infertile male and causes testis damage [J]. Gut, 2018, 67(6):1199-1201.
[15] MEDINA F A, TORRES G, ACEVEDO J, et al.Duration of the presence of infectious Zika virus in semen and serum [J]. J Infect Dis, 2019, 219(1): 31-40.
[16] BIAN Xiuwu，COVID-19 pathology team. autopsy of COVID-19 patients in China [J]. Natl Sci Rev, 2021,7(9): 1414-1418.
[17] ABBASI A Z, KIYANI D A, HAMID S M, et al.Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 [J]. J Med Virol, 2021, 93(7): 4205-4218.
[18] LI Honggang, XIAO Xingyuan, ZHANG Jie, et al.Impaired spermatogenesis in COVID-19 patients [J]. E Clinical Medicine, 2020, 28: 100604.
[19] MOHAMAD N V, WONG S K, WAN HASAN W N,et al. The relationship between circulating testosterone and inflammatory cytokines in men [J]. Aging Male,2019, 22(2): 129-140.
[20] COLLINS A B, ZHAO Lei, ZHU Ziwen, et al. Impact of COVID-19 on male fertility [J]. Urology, 2022, 164: 33-39.
[21] YASSIN A, SABSIGH R, AL-ZOUBI R M, et al.Testosterone and COVID-19: An update [J]. Rev Med Virol, 2022: e2395. https://doi.org/10.1002/rmv.2395.
[22] ALI BR, ATIYAH S A, YSER H T, et al. The influence of SARS-CoV-2 on semen parameters of infected infertile male in comparison with those that noninfected[J]. J Clin Lab Anal, 2022, 36(8): e24568.
[23] JUNG A, SCHUPPE H C, SCHILL W B. Fever as etiology of temporary infertility in the man [J].Hautarzt, 2001, 52(12):1090-1093.
[24] PALLOTTI F, ESTEVES S C, FAJA F, et al.COVID-19 and its treatments: lights and shadows on testicular function [J]. Endocrine, 2022: 1-9. https://doi.org/10.1007s12020-022-03221-6.
[25] TEMIZ M Z, DINCER M M, HACIBEY I, et al.Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile:A cross-sectional, pilot study[J]. Andrologia, 2021,53(2):e13912. .
[26] PAN Yang , WANG Shangren , KANG Jiaqi, et al.Association between generalized anxiety symptoms and semen quality in infertile men: A multicentre study in North China [J]. Andrologia, 2022, 54(8):e14449.
[27] BHONGADE M B, PRASAD S, JILOHA R C, et al.Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples [J].Andrologia, 2015, 47(3): 336-342.
[28] DONDERS G G G, BOSMANS E, REUMERS J, et al. Sperm quality and absence of SARS-CoV-2 RNA in semen after COVID-19 infection: a prospective,observational study and validation of the SpermCOVID test[J]. Fertil Steril, 2022, 117(2):287-296.
[29] NETO F T, BACH P V, NAJARI B B, et al.Spermatogenesis in humans and its affecting factors [J].Semin Cell Dev Biol, 2016, 59:10-26.
[30] RUAN Yajun, HU Bintao , LIU Zhuo , et al. No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: A perspective and urogenital evaluation [J]. Andrology, 2021, 9(1):99-106.
[31] WANG Meng, HU Juan, HUANG Bo, et al.Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro fertilization/intracytoplasmic sperm injection outcomes: a retrospective cohort study[J]. Reprod Biol Endocrinol,2022, 20(1): 46.
[32] 马俊娥, 崔湘铧, 刘芮, 等. 新型冠状病毒肺炎患者血浆CRP,PCT 和IL-6 水平检测的临床诊断价值[J].现代检验医学杂志,2021,36(5):105-109.
MA June, CUI Xianghua, LIU Rui, et al. Diagnostic value of determination of plasma CRP, PCT and IL-6 levels in patients with COVID-19 [J]. Journal of Modern Laboratory Medicine, 2021, 36(5): 105-109.
[33] 闫美田, 郑雨桐, 孙艳美, 等. 新型冠状病毒肺炎患者血液CRP, CREA, ALB, IL-6 水平检测对疾病预后的应用价值分析[J]. 现代检验医学杂志,2020,35(5):106-109.
YAN Meitian,ZHENG Yutong,SUN Yanmei,et al.Analysis of the value of detection of blood CRP,CREA,ALB and IL-6 level in patients with new coronavirus pneumonia to the prognosis of the disease[J].Journal of Modern Laboratory Medicine,2020,35(5):106-109.
[34] GLAZER C H, EISENBERG M L, T?TTENBORG S S, et al. Male factor infertility and risk of death: a nationwide record-linkage study[J]. Hum Reprod, 2019,34(11):2266-2273.

相似文献/References:

[1]谢　辉,刘玮玮b,郭　娟a,等.新型冠状病毒肺炎疫情下检验医学临床服务管理的探索[J].现代检验医学杂志,2020,35(03):81.[doi:10.3969/j.issn.1671-7414.2020.03.020]
　XIE Huia,LIU Wei-weib,GUO Juana,et al.Exploration on Clinical Service Management of Laboratory Medicine during COVID-19 Epidemic Period[J].Journal of Modern Laboratory Medicine,2020,35(01):81.[doi:10.3969/j.issn.1671-7414.2020.03.020]
[2]朱传新,周玉平,何　艳,等.92 例新冠肺炎病毒感染患者早期外周血白细胞形态分析[J].现代检验医学杂志,2020,35(03):94.[doi:10.3969/j.issn.1671-7414.2020.03.024]
　ZHU Chuan-xin,ZHOU Yu-ping,HE Yan,et al.Morphological Analysis of Early Peripheral Blood Leukocytes in 92 Patients with New Coronary Pneumonia[J].Journal of Modern Laboratory Medicine,2020,35(01):94.[doi:10.3969/j.issn.1671-7414.2020.03.024]
[3]刘艳霞,区静怡,黄 颖,等.新型冠状病毒肺炎患者外周血淋巴细胞及其亚群检测的临床意义[J].现代检验医学杂志,2020,35(04):94.[doi:10.3969/j.issn.1671-7414.2020.04.023]
　LIU Yan-xia,OU Jing-yi,HUANG Ying,et al.Clinical Significance of Detection of Peripheral Blood Lymphocyte and Its Subgroups in Patients with Coronavirus Disease 2019[J].Journal of Modern Laboratory Medicine,2020,35(01):94.[doi:10.3969/j.issn.1671-7414.2020.04.023]
[4]佟 丽,黄丽萍,石晓霞,等.血栓弹力图检测新型冠状病毒肺炎患者凝血功能的探讨分析[J].现代检验医学杂志,2020,35(04):97.[doi:10.3969/j.issn.1671-7414.2020.04.024]
　TONG Li,HUANG Li-ping,SHI Xiao-xia,et al.Investigation and Analysis of Thromboelastography in the Detection of COVID-19 Patients[J].Journal of Modern Laboratory Medicine,2020,35(01):97.[doi:10.3969/j.issn.1671-7414.2020.04.024]
[5]朱旭阳,叶寒青,陈文亥,等.新型冠状病毒肺炎患者血清SARS-CoV-2 抗体的检测分析[J].现代检验医学杂志,2020,35(04):106.[doi:10.3969/j.issn.1671-7414.2020.04.026]
　ZHU Xu-yang,YE Han-qing,CHEN Wen-hai,et al.Preliminary Analysis of Serum Antibodies Against SARS-CoV-2 in Patient with Coronavirus Disease 2019[J].Journal of Modern Laboratory Medicine,2020,35(01):106.[doi:10.3969/j.issn.1671-7414.2020.04.026]
[6]白欢,沈玲,袁旭,等.新型冠状病毒肺炎患者早期外周血实验室检查结果分析[J].现代检验医学杂志,2020,35(05):93.[doi:10.3969/j.issn.1671-7414.2020.05.024]
　BAI Huan,SHEN Ling,YUAN Xu,et al.Analysis of the Characteristics of Hematological Parameters in the Early Stages of COVID-19[J].Journal of Modern Laboratory Medicine,2020,35(01):93.[doi:10.3969/j.issn.1671-7414.2020.05.024]
[7]张园,周泽奇,王志贤,等.新型冠状病毒核酸、抗原和抗体联合检测的临床价值讨论[J].现代检验医学杂志,2020,35(05):99.[doi:10.3969/j.issn.1671-7414.2020.05.025]
　ZHANG Yuan,ZHOU Ze-qi,WANG Zhi-xian,et al.Discussion on the Clinical Value of Combined Detection of SARS-CoV-2 Nucleic Acid，Antigen and Antibody[J].Journal of Modern Laboratory Medicine,2020,35(01):99.[doi:10.3969/j.issn.1671-7414.2020.05.025]
[8]陈赛,刘海艇,李铁,等.新型冠状病毒肺炎患者肝功能异常的相关临床分析[J].现代检验医学杂志,2020,35(05):103.[doi:10.3969/j.issn.1671-7414.2020.05.026]
　CHEN Sai,LIU Hai-ting,LI Tie,et al.Clinical Analysis of Abnormal Liver Function in Patients with New Coronavirus Pneumonia[J].Journal of Modern Laboratory Medicine,2020,35(01):103.[doi:10.3969/j.issn.1671-7414.2020.05.026]
[9]闫美田,郑雨桐,孙艳美,等.新型冠状病毒肺炎患者血液CRP, CREA, ALB, IL-6 水平检测对疾病预后的应用价值分析[J].现代检验医学杂志,2020,35(05):106.[doi:10.3969/j.issn.1671-7414.2020.05.027]
　YAN Mei-tian,ZHENG Yu-tong,SUN Yan-mei,et al.Analysis of the Value of Detection of Blood CRP,CREA,ALB and IL-6 Level in Patients with New Coronavirus Pneumonia to the Prognosis of the Disease[J].Journal of Modern Laboratory Medicine,2020,35(01):106.[doi:10.3969/j.issn.1671-7414.2020.05.027]
[10]王琳琳a,张晓凝,王刚b,等.外周血白细胞参数对于新型冠状病毒肺炎诊断的临床意义[J].现代检验医学杂志,2020,35(05):110.[doi:10.3969/j.issn.1671-7414.2020.05.028]
　WANG Lin-lina,ZHANG Xiao-ning,WANG Gangb,et al.Clinical Significance of Peripheral Blood Leukocyte Parameters in the Diagnosis of COVID-19[J].Journal of Modern Laboratory Medicine,2020,35(01):110.[doi:10.3969/j.issn.1671-7414.2020.05.028]

备注/Memo

备注/Memo:
作者简介：杨磊（1991-），女，硕士，主管检验师，研究方向：临床与生殖检验，E-mail：shangcl21@163.com。
通讯作者：许涛（1987-），男，硕士，主管检验师，研究方向：临床病毒核酸诊断及其流行病学调查，E-mail：dazhuxt126@126.com。
更新日期/Last Update: 2023-01-15