[1]汪艳丽a,韩彩莉b,李 卫c,等.甲状腺功能相关基因多态性与抑郁障碍及抗抑郁治疗疗效的相关性研究[J].现代检验医学杂志,2023,38(04):8-15+58.[doi:10.3969/j.issn.1671-7414.2023.04.002]
　WANG Yanlia,HAN Cailib,LI Weic,et al.Association Study of Polymorphisms of Thyroid Function-related Genes with Depression and Antidepressant Efficacy[J].Journal of Modern Laboratory Medicine,2023,38(04):8-15+58.[doi:10.3969/j.issn.1671-7414.2023.04.002]
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甲状腺功能相关基因多态性与抑郁障碍及抗抑郁治疗疗效的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年04期
页码:
8-15+58
栏目:
论著
出版日期:
2023-07-15

文章信息/Info

Title:
Association Study of Polymorphisms of Thyroid Function-related Genes with Depression and Antidepressant Efficacy
文章编号:
1671-7414（2023）04-008-09
作者:
汪艳丽a; 韩彩莉b; 李 卫c; 谭文云d; 徐盼盼d; 张瑛琪d; 苏冠丽a; 靳小静d
（河北医科大学第一医院a. 精神卫生科；b. 医务处；c. 胃肠外科；d. 急诊科，石家庄 050000）
Author(s):
WANG Yanlia ;  HAN Cailib;  LI Weic;  TAN Wenyund;  XU Panpand;  ZHANG Yingqid;  SU Guanlia;  JIN Xiaojingd
（a .Department of Mental Health；b. Department of Emergency；c. Department of Gastrointestinal Surgery； d. Department of Emergency，the First Hospital of Hebei Medical University，Shijiazhuang 050000，China）
关键词:
甲状腺功能相关基因多态性; 抑郁症
分类号:
R749.41；Q786
DOI:
10.3969/j.issn.1671-7414.2023.04.002
文献标志码:
A
摘要:
目的　探讨甲状腺功能相关基因多态性（single nucleotide polymorphism，SNP）与抑郁障碍及抗抑郁治疗效果的关系。方法　回顾性选择2015 年3 月～ 2021 年6 月于河北医科大学第一医院门诊或住院治疗的328 例抑郁障碍患者为研究对象（观察组），并以患者的甲状腺功能分为异常组（n=141）和正常组（n=187）。另招募同期健康志愿者536 例作为对照（对照组）。所有患者均接受8 周治疗，治疗前后采用汉密尔顿抑郁量表17 项（Hamilton depressionscale 17，HAMD-17）对抑郁状况进行评估，根据疗效将患者分为缓解组（n=191）和非缓解组（n=137），比较两组患者的甲功相关基因SNP 等位基因及基因型频率，分析甲功相关基因不同等位基因及基因型与抗抑郁治疗疗效的关系。结果　对照组和观察组rs2235544 位点A 等位基因占比49.53%，55.34%，AA 基因型人群占比23.13%，32.01%，差异具有统计学意义（χ2=5.486, 8.233, 均P ＜ 0.05）；两组rs2046045 位点C 等位基因占比82.28%, 92.23%，CC 基因型人群占比66.98%, 86.59%，差异具有统计学意义（χ2=33.567, 43.223, 均P ＜ 0.05）。正常组和异常组rs2235544 位点A 等位基因占比37.97%，58.87%，AA 基因型人群占比22.99%，36.17%，差异具有统计学意义（χ2=14.094, 6.825, 均P ＜ 0.05）；两组rs2046045 位点C 等位基因占比79.14%，92.20%，CC 基因型人群占比65.78%，86.52%，差异具有统计学意义（χ2=10.603, 18.311, 均P ＜ 0.05）。缓解组和未缓解组rs2235544 位点A 等位基因占比44.76%，56.93%，AA 基因型人群占比24.61%，37.96%，差异具有统计学意义（χ2=9.453，7.984，均P ＜ 0.05）；rs2046045 位点C 等位基因占比83.51%，89.78%，CC 基因型人群占比69.63%，81.75%，差异具有统计学意义（χ2=5.255，0.648，均P＜ 0.05）。rs2235544 位点的AC，CC，AA 基因型患者治疗后HAMD 总分为4.87±1.15，4.94±1.06 和8.63±2.03，减分率为79.59±13.93，79.54±14.82 和62.96±14.16，差异具有统计学意义（F=10.928, 5.678, 均P ＜ 0.05）。s2046045位点的AC，AA 和CC 基因型患者治疗后HAMD 总分为4.98±1.10, 5.16±1.23 和7.54±1.89，减分率为79.04±14.95,78.32±15.07 和66.95±12.43，差异具有统计学意义（F=7.158，2.212, 均P ＜ 0.05）。rs2235544 位点的CC，AC 和AA基因型的患者在焦虑/ 躯体化（5.14±1.22, 5.62±1.36 和5.81±1.79）、认知障碍（2.84±1.56, 4.97±1.69 和5.13±1.84）、绝望感（2.91±1.26, 4.83±1.65 和5.57±1.89）方面比较，差异具有统计学意义（F=2.735，8.560，10.338，均P ＜ 0.05）。rs2046045 位点的AA，AC 和CC 基因型的患者在认知障碍（3.05±1.24, 4.67±1.21 和5.09±1.22）、绝望感（2.87±1.19,4.75±1.72 和5.48±1.92）方面比较，差异具有统计学意义（F=4.369, 3.576, 均P ＜ 0.001）。结论　碘甲腺原氨酸脱碘酶I（DIO1）基因rs2235544 及PDE8B 基因rs2046045 多态性与抑郁障碍及抑郁症疗效相关；rs2235544 位点的A 基因及rs2046045 位点的C 基因是抑郁障碍及抑郁症患者治疗效果不佳的危险因素。
Abstract:
Objective　To explore the relationship between thyroid function related gene polymorphism (SNP) and depressive disorder and antidepressant treatment. Methods　328 patients with depressive disorder treated in the outpatient or inpatient department of the First Hospital of Hebei Medical University from March 2015 to June 2021 were retrospectively selected as the study subjects (observation group), and 536 healthy volunteers were recruited as the control group. All patients were treated for 8 weeks. Before and after treatment, the depression status was assessed by Hamilton Depression Scale 17 (HAMD-17). According to the curative effect, the patients were divided into remission group (n=191) and non remission group (n=137). The SNP alleles and genotype frequencies of nail function related genes in the two groups were compared, and the relationship between different alleles and genotypes of nail function related genes and the efficacy of antidepressant treatment was analyzed. Results　The proportion of a allele at rs2235544 locus in the control group and the observation group (49.53%, 55.34%), and the proportion of AA genotype population (23.13%, 32.01%), the differences were statistically significant (χ2=5.486, 8.233, all P < 0.05). The proportion of C allele at rs2046045 locus (82.28%, 92.23%) and the proportion of CC genotype population (66.98%, 86.59%) in the two groups were statistically significant (χ2=33.567, 43.223, all P < 0.05). The proportion of a allele at rs2235544 locus in normal group and abnormal group (37.97%, 58.87%), and the proportion of AA genotype population (22.99%, 36.17%), the differences were statistically significant (χ2=14.094, 6.825, all P < 0.05) . The proportion of C allele at rs2046045 locus (79.14%, 92.20%) and the proportion of CC genotype population (65.78%, 86.52%) in the two groups were statistically significant (χ2=10.603, 18.311, all P < 0.05). The proportion of a allele at rs2235544 locus in remission group and non remission group (44.76%, 56.93%), and the proportion of AA genotype population (24.61%, 37.96%), the differences were statistically significant (χ2=9.453, 7.984, all P < 0.05) . The proportion of C allele at rs2046045 locus (83.51%, 89.78%), and the proportion of CC genotype population (69.63%, 81.75%), the differences were statistically significant (χ2=5.255, 0.648, all P < 0.05). After treatment, the total score of HAMD in patients with AC, CC and AA genotypes at rs2235544 was 4.87±1.15, 4.94±1.06 and 8.63±2.03, and the reduction rate was 79.59±13.93, 79.54±14.82 and 62.96±14.16，the differences weres statistically significant (F=10.928, 5.678, all P < 0.05). After treatment, the total score of HAMD in patients with AC, AA and CC genotypes at s2046045 was 4.98±1.10, 5.16±1.23 and 7.54±1.89, and the reduction rate was 79.04±14.95, 78.32±15.07 and 66.95±12.43，the differences were statistically significant (F=7.158, 2.212, all P < 0.05). There were significant differences in anxiety / somatization (5.14±1.22, 5.62±1.36 and 5.81±1.79), cognitive impairment (2.84±1.56, 4.97±1.69 and 5.13±1.84), and despair (2.91±1.26, 4.83±1.65 and 5.57±1.89) among patients with CC, AC and AA genotypes at rs2235544，the differences were statistically significant (F=2.735, 8.560, 10.338, all P < 0.05). Compared with patients with AA, AC and CC genotypes at rs2046045, there were significant differences in cognitive impairment (3.05±1.24, 4.67±1.21 and 5.09±1.22) and despair (2.87±1.19, 4.75±1.72 and 5.48±1.92), the differences were statistically significant (F=4.369, 3.576, all P < 0.001). Conclusion　The polymorphisms of DIO1 gene rs2235544 and PDE8B gene rs2046045 were associated with the efficacy of depression and depression. The C gene at rs2235544 and the A gene at rs2046045 were risk factors for depressive disorders and poor treatment effects in patients with depression.

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备注/Memo

备注/Memo:
基金项目： 2018 年度河北省医学科学研究重点课题计划（20180213）：急性精神应激（抑郁症）与甲状腺功能的关系研究；2020 年度河北医科大学第一医院“星火”青年科研项目计划表（XH202013）：基于大数据分析及临床试验验证，在外周血中确定与帕金森病相关的生物标记物。
作者简介：汪艳丽（1987-），女，学士，主管护师，研究方向：精神心理疾病的治疗与护理，E-mail：476483585@qq.com。
通讯作者：靳小静（1986-），女，博士，主治医师，研究方向：精神医学、内分泌学及急诊医学，E-mail：Xiaojing1987623@163.com。
更新日期/Last Update: 2023-07-15