[1]齐 亮,刘文广,郑金玉,等.三叉神经痛患者血清神经元特异性烯醇化酶水平与行经皮球囊压迫术后复发的相关性研究[J].现代检验医学杂志,2025,40(02):180-185.[doi:10.3969/j.issn.1671-7414.2025.02.034]
　QI Liang,LIU Wenguang,ZHENG Jinyu,et al.Study on the Correlation between Serum NSE Levels and Recurrence after Percutaneous Balloon Compression Surgery in Patients with Trigeminal Neuralgia[J].Journal of Modern Laboratory Medicine,2025,40(02):180-185.[doi:10.3969/j.issn.1671-7414.2025.02.034]
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三叉神经痛患者血清神经元特异性烯醇化酶水平与行经皮球囊压迫术后复发的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年02期
页码:
180-185
栏目:
论著
出版日期:
2025-03-15

文章信息/Info

Title:
Study on the Correlation between Serum NSE Levels and Recurrence after Percutaneous Balloon Compression Surgery in Patients with Trigeminal Neuralgia
文章编号:
1671-7414（2025）02-180-06
作者:
齐 亮; 刘文广; 郑金玉; 季欢欢
（淮安市第二人民医院/ 徐州医科大学附属淮安医院，江苏淮安 223000）
Author(s):
QI Liang; LIU Wenguang; ZHENG Jinyu; JI Huanhuan
（Huai’an Second People’s Hospital / Huai’an Hospital Affiliated to Xuzhou Medical University，Jiangsu Huai’an 223000，China）
关键词:
神经元特异性烯醇化酶; 三叉神经痛; 经皮球囊压迫术
分类号:
R745.11；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.02.034
文献标志码:
A
摘要:
目的 探讨血清神经元特异性烯醇化酶(NSE) 水平与三叉神经痛(TN) 患者行经皮球囊压迫术(PBC) 后复发的相关性。方法 选择2018 年7 月～ 2021 年4 月在江苏省淮安市第二人民医院行PBC 的TN 患者166 例作为研究对象。根据术后二年复发情况分为复发组(n =22) 和未复发组(n =144)，比较两组患者的一般资料，分析TN 患者PBC 前后的血清标志物水平及TN 患者PBC 术后疗效。比较各炎症标志物和神经损伤标志物术前(T1) 和术后2 天(T2) 的差值变化(T2-T1)，将有显著变化的各指标差值和预后复发进行关联分析(Spearman 相关及Logistic 回归），探讨血清NSE对TN 患者PBC 后复发的预测价值。结果 TN 患者PBC 前1 天的血清NSE 水平（12.39±3.15ng/ml）与PBC 后2 天的血清NSE 水平（16.27±4.03ng/ml）比较，差异具有统计学意义（t=14.922，P<0.001）。复发组患者PBC 前后的血清NSE 差值为5.72(5.25，7.58) ng/ml, 未复发组患者PBC 前后的血清NSE 差值为3.01(2.63，3.37) ng/ml，二者比较差异具有统计学意义（Z=3.925，P ＜ 0.001）。Logistic 回归分析显示：PBC 前后血清NSE 差值(T2-T1) 是TN 患者术后二年复发的危险因素(OR=1.602，Wald χ2=12.252，P ＜ 0.05)。ROC 分析结果：PBC 前后血清NSE 差值(T2-T1) 对TN 患者术后二年复发的预测效能AUC(95%CI) 为0.777(0.587 ～ 0.954)，预测阈值为4ng/ml，对应的灵敏度和特异度分别为0.727，0.806。结论 血清NSE 可能成为预测TN 患者PBC 治疗后复发的生物标志物。
Abstract:
Objective To explore the correlation between neuron specific enolase(NSE) levels and recurrence after percutaneous balloon compression (PBC) in patients with trigeminal neuralgia (TN). Methods 166 TN patients who underwent PBC at the Second People’s Hospital of Huai’an City，Jiangsu Province from July 2018 to April 2021 were selected as the study subjects. According to the recurrence rate after 2 years of surgery, patients were divided into a recurrence group (n=22) and a nonrecurrence group (n=144). The general information of the two groups of patients was compared, and the serum biomarker levels before and after PBC in TN patients were analyzed, as well as the postoperative efficacy of TN patients with PBC. Compared the difference changes (T2-T1) between various inflammatory markers and nerve injury markers before surgery (T1) and 2 days after surgery (T2), and perform correlation analysis (Spearman correlation and Logistic regression) between the significantly changed difference indicators and prognosis recurrence to explor the predictive value of serum NSE for recurrence after PBC in TN patients. Results The serum NSE level of TN patients on the first day of PBC was 12.39±3.15 ng/ml, were compored with those on the second day after PBC was 16.27±4.03ng/ml, and the difference was statisically significant(t=14.922, P<0.01). The difference in serum NEC levels before and after PBC in the recurrent group was 5.72(5.25, 7.58)ng/ml, while the difference in serum NSE levels before and after PBC in the non-recurrent group was 3.01(2.63, 3.37)ng/ml, the difference between the two groups was statistically significant(Z=3.925, P<0.001). Logistic regression results showed that the difference in serum NSE levels(T2-T1) before and after PBC was a rish factor for postoperative recurrence in TN patients at two -years(OR=1.602, Wald χ2=12.252, P<0.05). ROC analysis tesults: the predictive power of serum NSE difference (T2-T1) before and after PBC for two-year recurrence in TN patients AUC(95%CI) was 0.777(0.587 ～ 0.954), and the prediction threshold was 4ng/ml. The corresponding sensitivity and specificity was 0.727 and 0.806, respectively. Conclusion Serum NSE may become a biomarker for predicting the recurrence of TN patients after PBC treatment.

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备注/Memo

备注/Memo:
作者简介：齐亮(1982-)，男，在职硕士，副主任医师，神经外科，研究方向：球囊压迫治疗三叉神经痛，E-mail：Qi6688liang99@126.com。
更新日期/Last Update: 2025-03-15