[1]乔雪峰a,黄志平b,张 宁c,等.IL-18基因启动子区-137G/C,-607G/T 2个位点基因多态性与女性乳腺癌易感性Meta分析[J].现代检验医学杂志,2016,31(04):65-69,73.[doi:10.3969/j.issn.16717-414.2016.04.017]
 QIAO Xue-fenga,HUANG Zhi-pingb,ZHANG Ningc,et al.Association Analysis of IL-18 Gene Promoter Region -137G/C,-607G/T Polymorphisms and Susceptibility to Sporadic Breast Cancer:Meta-Analysis[J].Journal of Modern Laboratory Medicine,2016,31(04):65-69,73.[doi:10.3969/j.issn.16717-414.2016.04.017]
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IL-18基因启动子区-137G/C,-607G/T 2个位点基因多态性与女性乳腺癌易感性Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
65-69,73
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Association Analysis of IL-18 Gene Promoter Region -137G/C,-607G/T Polymorphisms and Susceptibility to Sporadic Breast Cancer:Meta-Analysis
文章编号:
1671-7414(2016)04-065-06
作者:
乔雪峰1a黄志平1b张 宁1c崔 巍2王 虹1a袁慧茹1a吴秀茹1a贾 静1a王晓岩1a 黄 燕1a许 慧1a岳志刚1a
1.北京煤炭总医院a.检验科;
b.心脏中心;
c.口腔科, 北京 100028;
2.中国医学科学院 北京协和医学院 北京协和医院检验科,北京 100730
Author(s):
QIAO Xue-feng1aHUANG Zhi-ping1bZHANG Ning1cCUI Wei2WANG Hong1a YUAN Hui-ru1aWU Xiu-ru1aJIA Jing1aWANG Xiao-yan1a HUANG Yan1aXU Hui1aYUE Zhi-gang1a
a.Department of Clinical Laboratory;
b.Heart Disease Center;
c.Department of Dental,Beijing Meitan General Hospital,Beiiing 100028,China;
2.Department of Clinical Laboratory,Peking Union MedicalCollege Hospital, Peking Union Medical College,Chinese Academy of Medial Sciences,Beiiing100730,China
关键词:
乳腺癌 易感性 多态性 Meta分析 白细胞介素-18
分类号:
R737.9; R730.43
DOI:
10.3969/j.issn.16717-414.2016.04.017
文献标志码:
A
摘要:
目的 用Meta分析的方法综合评价IL-18基因启动子区-137G/C,-607G/T 2个位点基因多态性与女性散发性乳腺癌易感性间的关联性。方法 检索万方数据库Wanfang Data,中国学术期刊数据库CNKI,美国国立医学图书馆PUBMED及荷兰医学文摘EMBASE数据库,搜索有关IL-18基因启动子区多态性与乳腺癌易感性的所有中文或英文期刊文献,并检索纳入文献的 参考文献以防漏检,各数据库检索时限均为自建库始至2015年1月1日止。采用RevMan5.1软件进行不同文献间比值比OR值的合并分析,SAS9.4软件进行Kruskal-Wallis检验,对研究间各研究组组内数据进行纵向分析。结果 初检获得相关文献共计91篇,英文74篇,中文17篇。经筛选最终仅有3篇研究符合要求,共涉及6个研究组893人,包括乳腺癌组476例,健康对照组417例,各研究组人群均符合Hardy-Weinberg遗传平衡。Meta分析结果显示:①-607位点的基因型CC会降低乳腺癌的发病风险,合并后的OR值及95%CI分别为0.75和(0.56,1.00),总体效应量检验Z=1.97(P=0.05); Kruskal-Wallis检验显示-607位点和-137位点的乳腺癌组组间比较的检验结果和健康对照组组间比较的检验结果卡方值及P值分别为χ2=11.809 2,P=0.002 7; χ2=2.589 3,P=0.274 0和χ2=7.2936,P=0.006 9; χ2=0.005 8,P=0.939 5。结论 ①-607位点仅基因型CC与乳腺癌易感性相关联,是乳腺癌发生的保护因素,但等位基因与乳腺癌无关。②研究间结果的异质性主要来源于乳腺癌组。
Abstract:
Objective The goal of the present study was tocomprehensively evalue the relationship between IL-18 gene promoter region -607G/T,-137G/C sites polymorphism and the susceptibility of sporadic breast cancer.Methods Wanfang Database,China national knowledge infrastructure,Pubmed,Embase were retrieved to get all case-control studies from their inception to January 1,2015.In addition,references'list of the included articles and their related citations were also reviewed for additional articles.Results According the established inclusion criterias,3 studies with a total of cases and controls were identified.The pooled oddsratios and 95% CI for -607 genotype CC were 0.75 and(0.56,1.00),Z=1.97(P=0.05).Kruskal-Wallis test show genotype frequency of -607,-137 locibetween breast cancer group and healthy group among were significantly different.Chisquare and P were χ2=11.8092,P=0.002 7; and χ2=7.293 6,P=0.0069.Conclusion ①OnlyCC genotype in -607 loci was associated with susceptibility of breast cancer,and it is a protective factor for breast cancer,but there was no association between the allele and breast cancer.②The heterogeneity of the results among the 3 studies was mainly derived fromthe breast cancer group.

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备注/Memo

备注/Memo:
基金项目:煤炭总医院医学科研发展基金(K201602)。
作者简介:乔雪峰(1979-),男,硕士学位,主管检验技师,专业:临床检验诊断学,Tel:13269257081,E-mail:13269257081@163.com。
更新日期/Last Update: 2016-08-10