[1]朱 涛,王 伟a,吴和刚b.胃癌组织中FOXP1和FOXQ1的表达水平与临床病理特征及预后关系[J].现代检验医学杂志,2021,36(04):68-73.[doi:10.3969/j.issn.1671-7414.2021.04.015]
 ZHU Tao,WANG Weia,WU He-gangb.Expression of FOXP1 and FOXQ1 in Gastric Cancer and TheirRelationship with Clinicopathological Features and Prognosis[J].Journal of Modern Laboratory Medicine,2021,36(04):68-73.[doi:10.3969/j.issn.1671-7414.2021.04.015]
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胃癌组织中FOXP1和FOXQ1的表达水平与临床病理特征及预后关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
68-73
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Expression of FOXP1 and FOXQ1 in Gastric Cancer and TheirRelationship with Clinicopathological Features and Prognosis
文章编号:
1671-7414(2021)04-068-06
作者:
朱 涛1王 伟2a吴和刚2b
(1. 宜宾市中医医院普外科, 四川宜宾 644000;2. 宜宾市第一人民医院,a. 普外科;b. 病理科,四川宜宾 644000)
Author(s):
ZHU Tao1 WANG Wei2a WU He-gang2b
(1.Department of General Surgery, the Traditional Chinese Medicine Hospital of Yibin, Sichuan Yibin 644000, China;2a.Department of General surgery; 2b.Department of Pathology, the First People’s Hospital of Yibin, Sichuan Yibin 644000, China)
关键词:
胃癌叉头框蛋白P1叉头框蛋白Q1临床病理特征预后
分类号:
R735.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.04.015
文献标志码:
A
摘要:
目的 探讨胃癌组织中叉头框蛋白P1(FOXP1) 和叉头框蛋白Q1(FOXQ1) 的表达,并分析其与临床病理特征及预后关系。方法 选取2014 年1 月~ 2017 年2 月在宜宾市中医医院普外科确诊并接受根治性手术的胃癌患者156 例为研究对象,采用免疫组化EnVision 法分别检测患者胃癌组织及癌旁组织中FOXP1 和FOXQ1 的表达,分析其与临床病理参数的关系;采用Spearman 相关性分析胃癌组织中FOXP1 和FOXQ1 表达的相关性;采用Cox 比例风险回归模型分析患者预后的独立危险因素;采用Kaplan-Meier 生存分析法分析FOXP1,FOXQ1 表达与总体生存时间(OS) 的关系。结果 胃癌组织中FOXP1 高表达率低于癌旁组织,FOXQ1 高表达率高于癌旁组织,差异均有统计学意义(χ2=23.521,35.193, 均P < 0.05);胃癌组织中FOXP1,FOXQ1 的表达与病理分化程度、TNM 分期、淋巴结转移、肿瘤大小、脉管神经侵犯和浸润深度相关(χ2=6.054 ~ 14.909, 均P < 0.05);Spearman 相关分析显示,胃癌组织中FOXP1 与FOXQ1表达呈负相关(r=-0.526, P < 0.05);多因素Cox 回归分析显示,FOXP1 低表达、FOXQ1 高表达、FOXP1 低或无表达/FOXQ1高表达均是影响患者OS 的独立危险因素(P < 0.05);Kaplan‐Meier 法分析结果显示,FOXP1低或无表达/FOXQ1 高表达患者OS 短于其他患者(χ2=57.228, P < 0.05);FOXP1低或无表达/FOXQ1 高表达组OS 短于FOXP1 低或无表达患者和FOXQ1高表达患者(χ2=8.112, P < 0.05)。结论 FOXP1 蛋白在胃癌组织中低表达,FOXQ1 蛋白在胃癌组织中高表达,两者与疾病的发生发展及预后密切相关,两者联合检测能更好地判断患者的预后。

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备注/Memo

备注/Memo:
作者简介:朱涛(1975-),男,硕士研究生,副主任医师,研究方向:胃肠外科临床研究,E-mail: wjgg1009@163.com。
通讯作者:王伟,主任医师,mingyangwsj8853@sina.com。
更新日期/Last Update: 1900-01-01