[1]岳丹,王晓辉,付超,等.外周血异常糖链糖蛋白（TAP）检测对于肿瘤筛查及早期辅助诊断的意义[J].现代检验医学杂志,2020,35(05):62-64,92.[doi:10.3969/j.issn.1671-7414.2020.05.016]
　YUE Dan,WANG Xiao-hui,FU Chao,et al.Significance of Tumor Abnormal Protein (TAP) Peripheral Blood in the Detection of Tumor Screening and Early Auxiliary Diagnosis[J].Journal of Modern Laboratory Medicine,2020,35(05):62-64,92.[doi:10.3969/j.issn.1671-7414.2020.05.016]
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外周血异常糖链糖蛋白（TAP）检测对于肿瘤筛查及早期辅助诊断的意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
62-64,92
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
Significance of Tumor Abnormal Protein (TAP) Peripheral Blood in the Detection of Tumor Screening and Early Auxiliary Diagnosis
文章编号:
1671-7414（2020）05-066-04
作者:
岳丹1; 王晓辉1; 付超1; 郭林芝1; 李雪婷2
1. 山西医科大学基础医学院形态学实验室, 太原030000;2. 山西白求恩医院病理科, 太原030000
Author(s):
YUE Dan1; WANG Xiao-hui1; FU Chao1; GUO Lin-zhi1; LI Xue-ting2
1.Morphology Laboratory of Basic Medical College of Shanxi Medical University,Taiyuan 030001,China; 2.Department of Pathology, Shanxi Bethune Hospital,Taiyuan 030000,China
关键词:
异常糖链糖蛋白; 肿瘤筛查; 肿瘤辅助诊断
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2020.05.016
文献标志码:
A
摘要:
目的　探讨外周血异常糖链糖蛋白（tumour abmormal protein, TAP）检测在肿瘤早期辅助诊断及肿瘤筛查中的 意义。方法　选取 2019 年1~9 月山西白求恩医院肿瘤内科确诊为恶性肿瘤患者379 例（肿瘤组），门诊、住院部被诊 断为癌前病变的患者293 例（癌前病变组），这些病例均曾自愿进行过TAP 检测，记录检测结果，以同期体检中心曾 行TAP 检测的健康体检者1 763 例（对照组）为对照，分析比较TAP 检测结果。结果　对照组、癌前病变组、恶性肿 瘤组TAP 阳性率分别为1%，7% 和82.3%，三组间TAP 阳性率比较，差异有统计学意义（χ2 =1 703.147，P ＜ 0.001）； TAP 对肿瘤辅助诊断的灵敏度、特异度、阳性预测值分别为89.7%，96.8% 和87.3%，癌谱广；三组中TAP 检测阳性率 均与性别无关（χ2 =0.333 ～ 2.534，均P ＞ 0.05）。结论　TAP 检测灵敏度和特异度高，且不受性别限制，癌谱广，在 健康体检肿瘤筛查中值得广泛应用，对肿瘤的早期辅助诊断具有参考价值。
Abstract:
Objective　To investigate the significance of detecting normal blood chain glycoprotein (tumour abmormal protein, TAP) in the early diagnosis and tumor screening of tumors. Methods　From January to September 2019, 379 patients (tumor group) were diagnosed as malignant tumors in the Department of Oncology of Shanxi Bethune Hospital, and 293 patients (precancerous lesion group) were diagnosed as precancerous lesions in the outpatient and inpatient departments. All of them had voluntarily conducted TAP test and recorded the test results. Based on the comparison of 1 763 healthy people who had undergone TAP test in the physical examination center (control group) during the same period, the results of TAP test were analyzed and compared. Results　The positive rates of TAP in the control group, precancerous lesion group and malignant tumor group were 1%, 7% and 82.3% respectively. There was a statistically significant difference in the TAP positive rate among the three groups (χ2 = 1703.147, P ＜ 0.001). The sensitivity, specificity and positive predictive value of tumor diagnosis were 89.7%, 96.8% and 87.3%, respectively,and the positive rate of TAP test in the three groups was not related to gender (χ2 = 0.333~2.534, all P ＞ 0.05). Conclusion　The TAP test has high sensitivity and specificity for tumor diagnosis, is not limited by gender, and has a broad cancer spectrum. It is worthy of extensive application in tumor screening for healthy physical examination and has reference value for early auxiliary diagnosis of tumors.

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相似文献/References:

[1]王芳胜,熊敦勇,寇辉,等.血清AFP，CEA，CA-199与TAP在肝癌诊断中的应用价值[J].现代检验医学杂志,2015,30(05):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
　WANG Fang-sheng,XIONG Dun-yong,KOU Hui,et al.Application Value of Serum AFP，CEA，CA-199 and TAP in the Diagnosis of Hepatocellular Carcinoma[J].Journal of Modern Laboratory Medicine,2015,30(05):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
[2]刘丽燕a,陈晓丹b,杨明夏c,等.外周血异常糖链糖蛋白检测对非小细胞肺癌患者治疗监测的意义[J].现代检验医学杂志,2017,32(01):103.[doi:10.3969/j.issn.1671-7414.2017.01.028]
　LIU Li-yana,CHEN Xiao-danb,YANG Ming-xiac,et al.Significance of Tumor Abnormal Protein in Peripheral Blood in the Therapeutic Monitoring of Non-Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2017,32(05):103.[doi:10.3969/j.issn.1671-7414.2017.01.028]

备注/Memo

备注/Memo:
作者简介：岳丹（1990-），女，硕士研究生，助理实验师，研究方向: 病理学检验技术，E-mail:657494454@qq.com。
通讯作者：李雪婷（1986-），女，硕士研究生，主治医师，研究方向：肿瘤病理,E-mail：lxt19861227@163.com。
更新日期/Last Update: 2020-10-30