[1]唐四海.慢性乙型肝炎患者血清胱抑素C水平与其肝损伤程度的关系[J].现代检验医学杂志,2016,31(04):146-148,150.[doi:10.3969/j.issn.1671-7414.2016.04.042]
 TANG Si-hai.Relationship between the Level of Serum Cystatin C and Degree of Liver Damage in Patients with Chronic Hepatitis B[J].Journal of Modern Laboratory Medicine,2016,31(04):146-148,150.[doi:10.3969/j.issn.1671-7414.2016.04.042]
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慢性乙型肝炎患者血清胱抑素C水平与其肝损伤程度的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
146-148,150
栏目:
检验与临床
出版日期:
2016-08-10

文章信息/Info

Title:
Relationship between the Level of Serum Cystatin C and Degree of Liver Damage in Patients with Chronic Hepatitis B
文章编号:
1671-7414(2016)04-146-04
作者:
唐四海
铜陵市立医院检验科,安徽铜陵 244000
Author(s):
TANG Si-hai
Department of Clinical Laboratory, Tongling Municipal Hospital,Anhui Tongling 244000,China
关键词:
慢性乙型肝炎 胱抑素C 肝功能 损伤 程度 临床分度
分类号:
R512.62; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.04.042
文献标志码:
A
摘要:
目的 探讨慢性乙型肝炎(CHB)患者血清胱抑素C(CysC)水平与其肝损伤程度的关系。方法 选择2014年1月~12月间铜陵市立医院收治的CHB患者65例,依据CHB临床分度标准将其分为重度组22例、中度组19例、轻度组24例,另选择同期体检健康者26例作为健康对照组,采用免疫比浊法检测血清CysC,同时检测尿素(Urea)、血肌酐(SCr)、总胆红素(TBil)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和γ-谷氨酰转肽酶(γ-GT),并根据性别、年龄、SCr按公式计算肾小球滤过率(eGFR),比较各组CysC,Urea,SCr和eGFR,并分析CHB患者血清CysC与TBil,ALT,AST和γ-GT的相关性。结果 CHB重度组、CHB中度组、CHB轻度组及健康对照组血清CysC水平依次为1.35±0.23,1.18±0.24,1.02±0.20和0.75±0.18 mg/L; CHB各临床分度组血清CysC水平均高于健康对照组,差异均有统计学意义(t=5.587~10.852,均P<0.01); 血清CysC水平CHB重度组高于CHB中度组,CHB中度组又高于CHB轻度组,差异均有统计学意义(t分别为2.331,2.323,均P<0.05); 组间Urea,SCr,eGFR差异均无统计学意义(F=0.288~0.383,均P>0.05)。CHB患者血清CysC与TBil,ALT,AST,γ-GT均呈正相关(r=0.246~0.293,均P<0.05)。结论 血清CysC水平与CHB肝损伤程度有关,其可作为观察CHB患者肝损伤程度的指标。
Abstract:
Objective To investigate the relationship between the level of serum cystatin C(CysC)and degree of liver damage in patients with chronic hepatitis B(CHB).Methods 65 patients with CHB and 26 healthy individuals were selected as healthy controls in Tongling municipal hospital from January to December 2014.Patients with CHB were divided intosevere CHB group(n=22),moderate CHB group(n=19)and mild CHB group(n=24)according to clinical grading standard.Serum CysC was measured by immunonephelometry method.Urea,serum creatinine(SCr),Total bilirubin(TBil),alanine aminotransferase(ALT),aspartate aminotransferasein(AST)and γ-glutamyl transpeptidase(γ-GT)were also measured.Estimated glomerular filtration rate(eGFR)was estimated according to gender,age,SCr.The date from different groups were analyzed statistically.Results The levels ofserum CysC in severe CHB group,moderate CHB group,mild CHB group and healthy controls were 1.35±0.23,1.18±0.24,1.02±0.20 and 0.75±0.18 mg/L.Thelevels of serum CysC in severe CHB group,moderate CHB group and mild CHB groupwere all higher healthy controls(t=5.587~10.852,all P<0.01).Thelevel of serum CysC in severe CHB group was higher moderate CHB group and moderate CHB group was higher mild CHB group(t=2.331,2.323,P<0.05).Urea,SCr and eGFR were all not statistically significant between any two in each group(F=0.288~0.383,P>0.05).The level of serum CysC were positively correlated with TBil,ALT,AST and γ-GT in patients with CHB(r=0.246~0.293,P<0.05).Conclusion The level of serum CysC may becorrelated with degree of liver damage in patients with CHB,which indicate thatserum CysC may be used as an important index to evaluate degree of liver damagein patients with CHB.

参考文献/References:

[1] 王 朔,宋鉴清.肝病患者中血清胱抑素C测定的临床观察及意义[J].中国误诊学杂志,2011,11(21):5123. Wang S, Song JQ. Clinical observation and clinical significance ofdetermination of serum cystatin C in patients with liver diseases[J].Chin JMisdiagnostics,2011,11(21):5123.
[2] 魏 星.肝病患者血清胱抑素C测定的临床意义[J].河北中医,2013,35(7):1114-1115. Wei X.Clinical significance of determination of serum cystatin C inpatients with liver diseases[J].Hebei J TCM,2013,35(7):1114-1115.
[3] 赵永杰,鲁 岚.慢性乙肝患者血清Cys C浓度与肝功五项指标关系研究[J].国际检验医学杂志,2013,34(23):3256,插Ⅱ. Zhao YJ,Lu L.To study the relationship between serum cystatin C concentration and five indicators of liver function in patients with chronic hepatitis B[J].Int J Lab Med,2013,34(23):3256,putⅡ.
[4] 中华医学会肝病学分会,中华医学会感染病分会.慢性乙型肝炎防治指南(2010年版)[J].中华肝脏病杂志,2011,19(1):13-24. Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guidelines for prevention and treatmentof chronic hepatitis B(2010 Edition)[J].J Clin Hepatol,2011,19(1):13-24.
[5] 姚新洁,甄 萍,杜红利,等.糖皮质激素对血清胱抑素C表达的影响[J].现代检验医学杂志,2011,26(5):105-106,109. Yao XJ,Zhen P,Du HL,et al.Influence of glucocorticoids on serumcystatin C expression[J].J Mod Lab Med,2011,26(5):105-106,109.
[6] 中华医学会肝病学分会和感染病学分会.病毒性肝炎防治方案(2000年版)[J].中国预防医学杂志,2000,1(1):44-52. Chinese Society of Hepatology and Chinese Society of Infectious Disease.Viral hepatitis prevention plan(2000 Edition)[J].Chin Prev Med,2000,1(1):44-52.
[7] 全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. Chinese eGFR Investigation Collaboration.Modification and evaluation of MDRD estimating equation for Chinese patients with chronic kidney disease[J].Chin J Nephrol,2006,22(10):589-595.
[8] Iyer S,Wei S,Brew K,et al.Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1[J].J Biol Chem,2007,282(1):364-371.
[9] 曾广智,谭宁华,贾锐锐,等.组织蛋白酶及其抑制剂研究进展[J].云南植物研究,2005,27(4):337-354. Zeng GZ,Tan NH,Jia RR,et al.Cathepsins structures functionsand inhibitors[J].Acta Botanica Yunnanica,2005,27(4):337-354.
[10] 李 晖,杨永锐,杨晓冬,等.慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系研究[J].昆明医科大学学报,2014,35(2):80-82. Li H,Yang YR,Yang XD,et al.Correlation of se-rum lipoxin A4 with clinical grading of chronic hepatitis B patients[J].Journal of Kunming Medical University,2014,35(2):80-82.

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备注/Memo

备注/Memo:

作者简介:唐四海(1972-),男,本科,学士,副主任技师,主要从事临床检验诊断研究,Tel:13856218471,E-mail:tangsihai123456@163.com。
更新日期/Last Update: 2016-08-10