[1]赵 佳,左 林,姚创利,等.冠心病患者血清同型半胱氨酸水平与氧化应激的关系研究[J].现代检验医学杂志,2016,31(05):27-29.[doi:10.3969/j.issn.1671-7414.2016.05.007]
　ZHAO Jia,ZUO Lin,YAO Chuang-li,et al.Study on the Relationship between Serum Homocysteine Levels and Oxidative Stress in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(05):27-29.[doi:10.3969/j.issn.1671-7414.2016.05.007]
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冠心病患者血清同型半胱氨酸水平与氧化应激的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
27-29
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Study on the Relationship between Serum Homocysteine Levels and Oxidative Stress in Patients with Coronary Heart Disease
文章编号:
1671-7414(2016)05-027-03
作者:
赵 佳1; 左 林2; 姚创利1; 黎 阳1; 姜小建1
1.西安市中心医院检验科,西安 710003;
2.第四军医大学唐都医院放射科,西安 710038
Author(s):
ZHAO Jia1; ZUO Lin2; YAO Chuang-li1; LI Yang1; JIANG Xiao-jian1
1.Department of Clinical Laboratory,Xi'an Central Hospital,Xi'an 710003,China;
2.Department of Radiology, Tangdu Hospital of the Fourth Military Medical University,Xi'an 710038,China
关键词:
冠心病;  同型半胱氨酸;  氧化应激
分类号:
R541.4; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.05.007
文献标志码:
A
摘要:
目的 探讨冠心病(coronary heart disease,CHD)患者血清同型半胱氨酸(homocysteine,HCY)水平与氧化应激的关系。方法 按照2010年卫生部CHD诊断标准(WS 319～2010),选取2014年6～12月期间入住西安市中心医院的79例CHD患者作为实验组,并选取同期55例健康体检者作为正常对照组。通过检测血清中氧化应激标志物丙二醛(malondialhyde,MDA)水平和抗氧化酶超氧化物歧化酶(superoxide dismutase,SOD)活性,对机体氧化应激状态进行分析,再检测血清中HCY水平,将HCY水平与MDA水平及SOD活性进行相关性分析。结果 CHD组MDA水平显著高于对照组,而SOD活性显著低于对照组,差异具有统计学意义(t=3.112,2.684,均P<0.05)。CHD组HCY水平显著高于对照组,差异具有统计学意义(t=3.268,P<0.05)。CHD组HCY水平与MDA水平呈正相关(r=0.236,P<0.05),与SOD活性呈负相关(r=-0.221,P<0.05)。结论 CHD患者血清HCY水平升高,氧化应激反应增强。氧化应激与血清HCY水平升高有关,血清HCY水平升高和氧化应激在CHD发生发展过程中发挥重要作用。
Abstract:
Objective To investigate the relationship between serum homocysteine(HCY)levels and oxidative stress in patients with coronary heart disease(CHD).Methods According to the diagnostic criteria of CHD in 2010(WS 319-2010)issued by the Ministry of Health,79 patients with CHD in Xi'an Central Hospital from June 2014 to December 2014 wereselected as the experimental group,and 55 cases of healthy physical examination for the same period were selected as the normal control group.The levels of oxidative stress marker malondialdehyde(MDA)and the activity of antioxidant enzyme superoxide dismutase(SOD)in serum were detected to analyze the state of oxidative stress.The levels of serum HCY were detected,and the correlation between HCY levels and MDA levels and SOD activity was analyzed.ResultsThe levels of MDA in the CHD group were significantly higher than that in the control group,while SOD activity was significantly lower than that inthe control group,the differences were statistically significant(t=3.112,2.684,all P<0.05).The levels of HCY in the CHD group were significantly higher than that in the control group,the difference was statistically significant(t=3.268,P<0.05).In the CHD group,the levels of HCY were positively correlated with the levels of MDA(r=0.236,P<0.05),and negatively correlated with SOD activity(r=-0.221,P<0.05).Conclusion Serum HCY levels were increased and oxidative stress reaction was enhanced inpatients with CHD.Oxidative stress was associated with elevated serum HCY levels.Serum HCY levels and oxidative stress played an important role in the occurrence and development of CHD.

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备注/Memo

备注/Memo:
基金项目:陕西省科学技术研究发展计划项目(项目编号:2013K12-02-10)。
作者简介:赵 佳(1984-),女,博士,主管检验师,主要从事临床生物化学检验工作,E-mail:84911zj@163.com。
通讯作者:姚创利(1962-),男,本科,副主任检验师,主要从事临床生物化学检验工作,E-mail:yaocl7270@163.com。
更新日期/Last Update: 2016-10-30