[1]赵车冬,闫玉珠,吴文婧,等.血清CEA,CYFRA21-1,NSE水平在肺癌诊断与分型中的应用价值[J].现代检验医学杂志,2016,31(06):59-61，65.[doi:10.3969/j.issn.1671-7414.2016.06.016]
　ZHAO Che-dong,YAN Yu-zhu,WU Wen-jing,et al.Application Value of Serum CEA,CYFRA21-1 and NSE Levels in the Diagnosis and Typing of Lung Cancer[J].Journal of Modern Laboratory Medicine,2016,31(06):59-61，65.[doi:10.3969/j.issn.1671-7414.2016.06.016]
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血清CEA,CYFRA21-1,NSE水平在肺癌诊断与分型中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
59-61，65
栏目:
论著
出版日期:
2016-12-20

文章信息/Info

Title:
Application Value of Serum CEA,CYFRA21-1 and NSE Levels in the Diagnosis and Typing of Lung Cancer
作者:
赵车冬1; 闫玉珠2; 吴文婧1; 胡健1; 周萍1; 陈葳1
1.西安交通大学第一附属医院检验科,西安 710061; 2.西安市红会医院检验科,西安 710054
Author(s):
ZHAO Che-dong1; YAN Yu-zhu2; WU Wen-jing1; HUJian1; ZHOU Ping1; CHEN Wei1
1.Department of Clinical Laboratory, the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China; 2.Department of Clinical Laboratory,Xi'an Honghui Hospital,Xi'an 710054,China
关键词:
肺癌;  癌胚抗原;  细胞角蛋白19片段;  神经元特异性烯醇化酶;  联合检测
分类号:
R734.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.06.016
文献标志码:
A
摘要:
目的 探讨血清癌胚抗原(CEA),细胞角蛋白19片段(CYFRA21-1),神经元特异性烯醇化酶(NSE)水平在肺癌诊断、分型中的应用价值。方法收集79例肺癌患者,75例肺部良性疾病患者和163例健康体检者的空腹血清,采用电化学发光法检测血清CEA,CYFRA21-1和NSE水平,比较三项指标在肺癌诊断中的敏感度、特异度及阳性率,并比较在发生转移和未发生转移的肺癌患者血清CEA,CYFRA21-1和NSE水平。结果 与健康组和肺部良性疾病患者组相比,肺癌患者血清CEA,CYFRA21-1和NSE水平均明显升高,差异具有统计学意义(χ2=48.208～104.889,P<0.01)。联合两项或三项血清标志物的检测能明显提高对肺癌诊断的敏感度,但特异度有所下降。在不同病理类型的肺癌中,血清CEA,CYFRA21-1和NSE水平分别在腺癌、非小细胞肺癌、小细胞肺癌中的阳性率较高。发生转移的肺癌患者中的血清CEA水平高于未转移的肺癌患者(Z=-3.056,P=0.002)。结论 联合检测血清CEA,CYFRA21-1和NSE水平在不同病理类型肺癌诊断及转移中具有一定临床价值。
Abstract:
Objective To explore the application value of serum CEA,CYFRA21-1 and NSE in the diagnosis and typing of lung cancer.Methods The CEA,CYFRA21-1 and NSE levels in fasting blood serum from 79 lung cancer patients,75 pulmonary benign diseases and 163 healthy subjects were detected by electrical chemiluminescence immunoassay and the sensitivity,specificity and positive rate of these tumor markers were compared.The serumCEA,CYFRA21-1 and NSE levels were also compared between the lung cancer patients with metastasis and without metastasis.Results Compared to the healthy control group and pulmonary benign diseases patients,the serum CEA,CYFRA21-1 and NSE levels increased significantly in lung cancer patients(χ2=48.208～104.889,P<0.01).The joint detection of two or three tumor markers could improve the diagnostic sensitivity of lung cancer,while decrease specificity.In different pathological types of lung cancer,the positive rateof serum CEA was higher in adenocarcinoma,while CYFRA21-1 was higher in non-small cell lung cancer and NSE was higher in small cell lung cancer.The CEA level was higher in patients with metastasis than that without metastasis(Z=-3.056,P=0.002).Conclusion Joint detection of serum CEA,CYFRA21-1 and NSE could be considered in the early screen of lung cancer diagnosis and be valuable for typing and prognosis of lung cancer.

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备注/Memo

备注/Memo:
基金项目:西安交通大学第一附属医院科研发展项目(YK201522)。 作者简介:赵车冬(1985-),硕士研究生,检验师,主要研究方向:临床检验诊断学,E-mail:dongzi0925@126.com。 通讯作者:陈 葳(1962-),博士生导师,教授,主要研究方向:分子诊断学,E-mail:2398023255@qq.com。
更新日期/Last Update: 2016-12-20