[1]周萍,肖尧,袁瑞丽,等.血清Hcy和hs-CRP水平检测在AMI早期临床诊断中的临床应用[J].现代检验医学杂志,2016,31(06):79-81.[doi:10.3969/j.issn.1671-7414.2016.06.022]
　ZHOU Ping,XIAO Yao,YUAN Rui-li,et al.Application Value of Serum Hcy and hs-CRP Levels in Early Diagnosis of AMI[J].Journal of Modern Laboratory Medicine,2016,31(06):79-81.[doi:10.3969/j.issn.1671-7414.2016.06.022]
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血清Hcy和hs-CRP水平检测在AMI早期临床诊断中的临床应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
79-81
栏目:
论著
出版日期:
2016-12-20

文章信息/Info

Title:
Application Value of Serum Hcy and hs-CRP Levels in Early Diagnosis of AMI
作者:
周萍; 肖尧; 袁瑞丽; 王晓琴; 郭炫
周 萍,肖 尧,袁瑞丽,王晓琴,郭 炫
Author(s):
ZHOU Ping; XIAO Yao; YUAN Rui-li; WANG Xiao-qin; GUOXuan
Department of Clinical Laboratory, the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China
关键词:
同型半胱氨酸;  超敏C反应蛋白;  急性心肌梗死
分类号:
R542.22; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.06.022
文献标志码:
A
摘要:
目的 探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)检测在急性心肌梗死(AMI)患者早期诊断中的临床应用价值。方法 采用散射比浊法检测hs-CRP,酶循环法检测Hcy,分别对80例AMI患者,70例心绞痛(AP)患者,50例健康对照者血清Hcy和hs-CRP检测及其分析。结果 AMI组、AP组和对照组的hs-CRP(mg/L)水平依次为8.06±1.66,4.55±0.90和2.54±0.35,疾病组与对照组比较差异均有统计学意义(F=4.156,P=0.036 9); AMI组较AP组明显增高,差异有统计学意义(P<0.05 )。AMI组、AP组和对照组的Hcy(μmol/L)分别为36.37±7.54,22.67±3.94和11.28±1.73,疾病组与对照组比较差异均有统计学意义(F=3.264,P=0.023 4),AMI组较AP组明显增高,差异有统计学意义(P<0.05 )。AMI组和AP组的hs-CRP水平与Hcy水平均呈正相关(P<0.05)。结论 AMI患者血清Hcy,hs-CRP水平明显增高,二者联合检测对AMI的发生发展有重要价值。
Abstract:
Objective To investigate the clinical application value of serum homocysteine(Hcy)and high sensitive C reactive protein(hs-CRP)in early diagnosis of patients with acute myocardial infarction(AMI).Methods Hs-CRP were determined by scattering turbidimetry,enzymatic cycling assay was used to detect Hcy.Detected and analyzed serum Hcy and hs-CRP level in 80 cases of acute myocardial infarction(AMI)patients,70 cases of angina pectoris(AP)patients and 50 healthy controls.Results The levels of hs-CRP in AMI group,AP group and control groupwere 8.06±1.66 mg/L,4.55±0.90 mg/L and 2.54±0.35 mg/L.The difference between disease group and control group was statistically significant(F=4.156,P=0.036 9).AMI group was significantly higher than of AP group,the difference was statistically significant(P<0.05).The levels of Hcy in AMI group,AP group and control group were 36.37±7.54 μmol/L,22.67±3.94 μmol/L and 11.28±1.73 μmol/L respectively.The difference between disease group and control group were statistically significant(F=3.264,P=0.023 4),AMI group was significantly higher than that of AP group,the difference was statistically significant(P<0.05).The levels of hs-CRP in AMI group and that in AP group and were positively correlated(P<0.05).Conclusion Serum Hcy and hs-CRP levels were significantly elevatedin patients with acute myocardial infarction,combined detection of this two factors would have important value in the occurrence and development of acute myocardial infarction.

参考文献/References:

[1] Fournier P,Fourcade J,Roncalli J,et al.Homocysteine in chronic heart failure[J].Clin Lab,2015,61(9):1137-1145.
[2].Gürel E,Tigen K,Karaahmet T,et al.Predictive value of plasma asymmetric dimethylarginine,homocysteine,and high-sensitive CRP levels in occult coronary artery disease:A multidetector-row computed tomography study[J].Herz,2015,40(3):495-501.
[3] Koenig W.High-sensitivity C-reactive protein and atherosclerotic disease:from improved risk prediction to risk-guided therapy[J].Int J Cardiol,2013,168(6):5126-5134.
[4] Baron T,Hambraeus K,Sundstr(¨overo)m J,et al.Impact on long-term mortality of presence of obstructive coronary artery disease and classification of myocardial infarction[J].Am J Med,2016,129(4):398-406.
[5] 鲍晓明.急性心肌梗死的临床研究进展[J].临床医学,2015(13):34. Bao XM.Clinical study on acute myocardial infarction[J].ClinicalMedicine,2015(13):34.
[6] Hogh AL,Joensen J,Lindholt JS,et al.C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease[J].Vasc Endovascular Surg,2008,42(4):341-347.
[7] Garg PK,Mcclelland RL,Jenny NS,et al.Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort:The multi ethnic study of atherosclerosis[J].Atherosclerosis,2015,241(1):176-182.
[8] Schaffer A,Verdoia M,Cassetti E,et al.Novara atherosclerosis study group(NAS).Relationship between homocysteine and coronary artery disease.Results from a large prospective cohort study[J].Thromb Res,2014,134(2):288-293.
[9] Kuoppamaki M,Salminen M,Vahlberg T,et al.High sensitive C-reactive protein(hs-CRP),cardiovascular events and mortality in the aged:a prospective9-year follow-up study[J].Arch Gerontol Geriatr,2015,60(1):112-117.
[10] Anitha V,Nair S,Shivakumar V,et al.Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease[J].Indian J Dent Res,2015,26(5):500-503.

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备注/Memo

备注/Memo:
作者简介:周 萍(1975-),女,本科,主管检验师,主要从事临床免疫和肿瘤诊断。 通讯作者:郭 炫(1965-),女,主任技师,主要从事临床免疫学检验研究,E-mail:350449850@qq.com。
更新日期/Last Update: 2016-12-20