[1]陈雨欣,谭婷婷,宁明哲.乳腺癌患者血清中白介素35(IL-35)的表达及其临床意义[J].现代检验医学杂志,2017,32(02):92-94.[doi:10.3969/j.issn.1671-7414.2017.02.025]
　CHEN Yu-xin,TAN Ting-ting,NING Ming-zhe.Serological Interleukin-35 Level in Patients with Breast Cancer and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2017,32(02):92-94.[doi:10.3969/j.issn.1671-7414.2017.02.025]
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乳腺癌患者血清中白介素35(IL-35)的表达及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
92-94
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Serological Interleukin-35 Level in Patients with Breast Cancer and Its Clinical Significance
文章编号:
1671-7414(2017)02-092-03
作者:
陈雨欣; 谭婷婷; 宁明哲
南京大学医学院附属鼓楼医院检验科,南京 210008
Author(s):
CHEN Yu-xin; TAN Ting-ting; NING Ming-zhe
Department of Clinical Laboratory,Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China
关键词:
乳腺癌;  白介素-35;  病理分期;  转移
分类号:
R737.9; R730.43
DOI:
10.3969/j.issn.1671-7414.2017.02.025
文献标志码:
A
摘要:
目的 探讨乳腺癌患者血清中白介素35(interleukin-35,IL-35)的表达及其临床意义。方法 2015年1月～2016年7月期间南京市某三甲医院收治的54例乳腺恶性肿瘤患者为研究对象。乳腺癌病理分期:Ⅰ期12例,Ⅱ期15例,Ⅲ期12例,Ⅳ期15例。另外选择健康者54例作为对照。ELISA法比较患者及健康者血清中IL-35水平,并对其与其病理分期及是否发生肿瘤转移进行相关性分析。结果 乳腺癌患者血清中IL-35水平为21.07±8.01 ng/ml,显著高于健康人(11.99±5.30 ng/ml; t=6.88,P<0.001)。此外,病理分型Ⅰ期患者血清IL-35水平为14.95±6.52 ng/ml,Ⅱ期IL-35水平为20.59±8.15 ng/ml,Ⅲ期IL-35水平为24.94±6.64 ng/ml,Ⅳ期IL-35水平为23.35±6.93 ng/ml。Ⅲ期和Ⅳ期乳腺癌患者血清IL-35水平均高于Ⅰ期患者,其差异均具有统计学意义(t=3.562,P=0.002; t=3.363,P=0.001)。同时, 发生肿瘤转移的血清IL-35水平是23.95±6.95 ng/ml,明显高于未发生肿瘤转移的血清IL-35水平(18.19±7.97 ng/ml; t=2.779,P=0.008)。最后,乳腺癌患者血清中IL-35水平与其肿瘤病理分期(r=0.390,P=0.004)及肿瘤转移均呈正相关(r=0.361,P=0.008)。结论 IL-35水平与乳腺癌患者病理分期及发生肿瘤转移密切相关,具有一定的诊断意义,可以作为潜在的用于乳腺癌诊断的特异性标志物。
Abstract:
Objective To investigate the level of serological interleukin-35(IL-35)in breast cancer patients and its clinical significance.Methods From Jan 2015 to July 2016,serum of 55 patients with breast cancer were collected from a tertiary hospital of Nanjing.Their pathological stages were also analyzed,including 12 cases of stage Ⅰ,15 cases of stage Ⅱ,12 cases of stage Ⅲ,and 15 cases of stage Ⅳ.Meanwhile,serum from 54 healthy individuals also selected.The level of serological IL-35 was determined by ELISA,and the IL-35 level,pathological stage and tumor metastasis were analyzed by correlation analysis.Results The serum IL-35 in patients with breast cancer was significantly elevated than health individuals.With the increase in pathological stage,IL-35 level in breast cancer patients with stage Ⅲ and Ⅳ was significantly higher compared to patients with stage Ⅰ breast cancer(P<0.05).Further,patients with breast cancer metastasis had increased level of IL-35,compared to breast cancer patients without tumor metastasis(P<0.05).Finally,Spearman correlation analysis indicated that the serum level of IL-35 in patients with breast cancer was positlvely correlated with the pathological stages(r=0.390,P=0.004)and tumormetastasis(r=0.361,P=0.008)of the patients,respectively.Conclusion High level of IL-35 was detected in serum from breast cancer patients,and its expression was highly correlated with pathological stage and tumor metastasis.Detection of IL-35 could be applied as a valuable potentialbiomarker for the diagnosis of breast cancer.

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备注/Memo

备注/Memo:

作者简介:陈雨欣(1986-),女,博士,技师,研究方向:免疫学,Tel:17714413628,E-mail:yuxin chen2015@163.com。
更新日期/Last Update: 2017-04-10