[1]郭进京,胡林辉,陶千山,等.红细胞分布宽度在多发性骨髓瘤患者预后分期中的价值[J].现代检验医学杂志,2017,32(03):34-36，39.[doi:10.3969/j.issn.1671-7414.2017.03.009]
　GUO Jin-jing,HU Lin-hui,TAO Qian-shan,et al.Value of Red Cell Distribution Width in the Prognosis of Patients with Multiple Myeloma[J].Journal of Modern Laboratory Medicine,2017,32(03):34-36，39.[doi:10.3969/j.issn.1671-7414.2017.03.009]
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红细胞分布宽度在多发性骨髓瘤患者预后分期中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
34-36，39
栏目:
论著
出版日期:
2017-05-25

文章信息/Info

Title:
Value of Red Cell Distribution Width in the Prognosis of Patients with Multiple Myeloma
文章编号:
1671-7 414(2017)03-034-04
作者:
郭进京1; 胡林辉2; 3; 陶千山2; 3; 王卫国1 ; 张 夏1; 黄传荣1; 王伟伟1; 王建华1; 翟志敏2; 3
1.安徽医科大学附属阜阳市人民医院检验科，安徽阜阳 236000；
2.安 徽医科大学血液病研究中心， 合肥 230061；
3.安徽医科大学第二附属医院血液内科，合肥 230061
Author(s):
GUO Jin-jing1; HU Lin-hui2; 3; TAO Qian-shan 2; 3; WANG Wei-guo1; ZHANG Xia1;  HUANG Chuan-rong1; WANG Wei-wei1; WANG Jian-hua1; ZHAI Zhi-min 2
1.Department of Laboratory Medicine，the Fuyang People’s Hospi tal Affiliated to Anhui Medical University，Anhui Fuyang 236400，China；
2.Hematology Res earch Center， Anhui Medical University，Hefei 230061，China；
3.Department of Hematology ， the Second
关键词:
多发性骨髓瘤; 红细胞分布宽度; 预后分层
分类号:
R733.3；R730.43
DOI:
10.3969/j.issn.1671-7414.2017.03.009
文献标志码:
A
摘要:
目的 探讨多发性骨髓瘤(MM)患者红细胞分布宽度(RDW)与预 后分期的关系。方法 以27例初诊MM患者和30例正常人为研究对象， 根据血细胞检测结果计算得出RDW，比较两组RDW的差异；对MM患者进行国际标准分期(ISS) ，分析RDW在不同分期间的差异；用ISS分期进行分组，绘制受试者工作曲线(receiver oper ating characteristic curve，ROC 曲线)，取RDW 14.65%作为最佳截点，把MM患者分为低 RDW组(RDW≤14.65%)和高RDW组(RDW＞14.65%)，分析两组患者总体生存期(OS)的差异。生 存分析采用Kaplan-Meier法和Log-rank检验。结果 实验组和对照 组RDW水平分别为(15.60±2.35)％ vs (12.72±0.61)％，差异具有统计学意义(t=6 .201，P<0 .001)；低ISS分期(Ⅰ+Ⅱ期)和高ISS分期(III期)间RDW水平分别为(13.99 ±1.08)％　vs　(16.55±2.39)％，差异有统计学意义(t=3.800，P=0.001)；低R DW组和高RDW组的中位生存时间分别为13个月和8个月，差异有统计学意义(χ2 =6.481 ，P=0.011)。结论 RDW增高的MM患者，其危险分层更高，预后更 差。
Abstract:
Objective To investigate the relationship betwe en red blood cell distribution width (RDW) and prognosis in patients with multip le myeloma (MM)．Methods The population that studied c onsisted of 27 patients with multiple myeloma and 30 healthy controls．The RDW w as calculated according to the results of blood routine examination and compared between patients and healthy controls．Then，compared the difference between the two groups of RDW．MM patients were treated with international standard sta ging (ISS)，and the differences of RDW in different stages were analyzed．ISS st aging was used to draw the receiver operating curve (receiver operating characte ristic curve，ROC curve)，then take RDW14.65% as the best cut-off point，the M M patients were divided into low RDW group (RDW=14.65%) and high RDW group (RDW >14.65%)．Overall survival (OS) condition were compared between the above two groups．The impacts of RDW on OS were analyzed by Kaplan-Meier and Log-rank te st．Results The average RDW value in experimental and con trolled were 15.60%±2.35% vs 12.72%±0.61％ separately (t=6.201，P<0. 001)，with statistical differences．The average RDW value in low ISS(Ⅰ+Ⅱstage) and high ISS (III stage) were 13.99%±1.08％ vs 16.55%±2.39％ separately　 (t=3.800，P=0.001)．The median survival time of low RDW and high RDW group was 13 months and 8 months respectively，and the difference was statistically s ignificant (χ2=6.481，P=0.011)．Conc lusion RDW increased in patients with MM，the risk stratification hi gher prognosis is worse．

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备注/Memo

备注/Memo:
基金项目 ：国家自然科学基金(81670179，81401293)。
作者简介：郭进京(1982-)，男，硕士研究生，主管检验师，主要 从事血液病学研究，E-mail：969521266@qq.com。　
通讯作者：翟志敏(1962-)，女，教授，E-mail：zzzm889@163. com。
更新日期/Last Update: 2017-06-25