[1]段俊林,郭主声,陈伟.2017年广东省东莞地区儿童血培养病原菌分布及耐药性分析[J].现代检验医学杂志,2019,34(01):142-145.[doi:10.3969/j.issn.1671-7414.2019.01.037]
　DUAN Jun-lin,GUO Zhu-sheng,CHEN Wei.Analysis of Pathogen Distribution and Drug Resistance in Blood Culture of Children in Dongguan Area[J].Journal of Modern Laboratory Medicine,2019,34(01):142-145.[doi:10.3969/j.issn.1671-7414.2019.01.037]
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2017年广东省东莞地区儿童血培养病原菌分布及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
142-145
栏目:
检验与临床
出版日期:
2019-02-28

文章信息/Info

Title:
Analysis of Pathogen Distribution and Drug Resistance in Blood Culture of Children in Dongguan Area
文章编号:
1671-7414(2019)01-142-04
作者:
段俊林1; 郭主声2; 陈伟1
(1.东莞市中医院检验科，广东东莞523000； 2.中山大学附属东华医院检验科，广东东莞523110)
Author(s):
DUAN Jun-lin1; GUO Zhu-sheng2; CHEN Wei1
(1.Department of Clinical Laboratory，Dongguan Traditional Chine se Medicine Hospital， Guangdong Dongguan 523000，China；2.Department of Clinical Laboratory， Donghua Hospital Affiliated to Sun Yat-sen University，Guangdong Dongguan 523110，China)
关键词:
儿童; 血培养; 病原菌; 耐药性
分类号:
R446.5
DOI:
10.3969/j.issn.1671-7414.2019.01.037
文献标志码:
A
摘要:
目的了解广东省东莞地区儿童患者血培养病原菌临床分布 和耐药性情况。方法对2017年1～12月东莞市23家二级甲等及以 上参加细菌耐药监测的医疗机构的住院儿童患者血培养病原菌分布和耐药性进行回顾性分析 。结果广东省东莞地区儿童患者血培养全年共分离病原菌979株， 其中革兰阳性菌541株(占55.26％)，前三位病原菌为凝固酶阴性葡萄球菌(CNS)、金黄色葡 萄球菌和肺炎链球菌，分别占41.98％，3.57％和2.86％；革兰阴性菌431株(占44.02％ )，前三位病原菌为黏质沙雷菌、大肠埃希菌和斯氏假单胞菌，分别占13.68％，11.44 ％和5.31％；真菌7株(占0.72％)。药敏结果显示革兰阳性葡萄球菌对青霉素和氨苄西 林耐药率高，SCN耐药严重；革兰阴性杆菌对氨苄西林耐药严重，头孢哌酮/舒巴坦、哌拉西 林/他唑巴坦和碳青霉烯类敏感率较高。结论广东省东莞地区儿童 血培养以革兰阳性球菌为主，其中SCN占优势且耐药严重。应加强对儿童患者血培养病原菌 的耐药性监测，掌握其耐药特点以有效控制感染并减少多重耐药菌的产生。
Abstract:
Objective To understand the clinical distributi on and drug resistance of pathogen in blood culture of children in Dongguan Area of Guangdong Province．Methods The pathogen in blood cul ture of children isolated from hospitalized patients in 23 secondary and above m edical institutions which participated in bacterial monitoring in Dongguan from January 2017 to December 2017 were retrospectively analyzed．Resu les A total of 979 strains of pathogenic bacteria were isolated from the blood cultures of children in the whole year in Dongguan，including 541 str ains of gram-positive bacteria (55.26%)．The top three pathogens were coagulas e-negative Staphylococcus (CNS)， Staphylococcus aureus and Streptococ cus pneumoniae，accounted for 41.98%，3.57% and 2.86% respectively．431 str ains of gram-negative bacilli (44.02%).The top three pathogens were Serrat ia marcescens，Escherichia coli and Pseudomonas stutzeri ，accounted for 13 .68%，11.44% and 5.31% respectively，and 7 strains of fungi (0.72%)．Drug se nsit ivity test showed that the drug resistance rates of gram-positive Staphylococ cus to penicillin and ampicillin was higher．Coagulase-negative Saphylococc us drug esistance was serious．Gram-negative bacilli was highly resistant to ampicillin．The sensitivity rates of cefoperazone/sulbatam，piperacillin/tazobac tam and carbapenem were higher．Conclusion The blood cult ures of children were mainly gram-positive cocci in dongguan．The coagulase-n egative Staphylococcus was dominant and the drug resistance was serious．We should strengthen the monitoring of drug resistance of the isolated from blood s amples in order to take effective measures to control and prevent the emergence of multidrug resistance．

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备注/Memo

备注/Memo:

作者简介：段俊林(1980-)，男，硕士研究生，主管技师，研究方 向：微生物检验及耐药基因研究，E-mail：duanjunlin5@163.com。
更新日期/Last Update: 2019-02-28