[1]王 晶a,马 娟a,范 云a,等.2015～2017年陕西省人民医院临床血流感染病原菌的分布及耐药性分析[J].现代检验医学杂志,2019,34(04):87-90.[doi:10.3969/j.issn.1671-7414.2019.04.021]
　WANG Jinga,MA Juana,FAN Yuna,et al.Distribution and Drug Resistance of Pathogenic Bacteria of Blood Culture in Shaanxi Provincial People's Hospital form 2015 to 2017[J].Journal of Modern Laboratory Medicine,2019,34(04):87-90.[doi:10.3969/j.issn.1671-7414.2019.04.021]
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2015～2017年陕西省人民医院临床血流感染病原菌的分布及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
87-90
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Distribution and Drug Resistance of Pathogenic Bacteria of Blood Culture in Shaanxi Provincial People's Hospital form 2015 to 2017
文章编号:
1671-7414(2019)04-087-05
作者:
王 晶a; 马 娟a; 范 云a; 赵 海a; 谢小娟b; 李小侠a
(陕西省人民医院a.检验科; b.陕西省临床检验中心,西安 710068)
Author(s):
WANG Jinga; MA Juana; FAN Yuna; ZHAO Haia; XIEXiao-juanb; LI Xiao-xiaa
(a.Department of Laboratory Medicine; b.Shaanxi Center for Clinical Laboratory,Shaanxi Provencial People's Hospital,Xi'an 710068,China)
关键词:
血流感染;  血培养;  病原菌;  耐药性
分类号:
R446.5
DOI:
10.3969/j.issn.1671-7414.2019.04.021
文献标志码:
A
摘要:
目的 分析陕西省人民医院2015～2017年血培养病原菌的分布及耐药性变迁,为临床诊断和治疗提供数据依据。方法 收集2015～2017年住院患者血培养阳性标本2 599份,依据美国临床实验室标准化协会(CLSI)2016年标准,采用WHONET 5.6和SPSS17.0软件进行数据分析。结果 2 599株病原菌中革兰阳性菌1 141株(43.9%); 革兰阴性菌1 282株(49.3%)和真菌176株(6.8%)。临床科室以重症医学科(425株,16.4%)、新生儿科(188株,7.2%)、急诊外科(216株,8.3%)、呼吸内科(199株,7.7%)和肝胆外科(185株,7.1%)等为主。血培养阳性菌存在季节分布,夏季高于其他季节。革兰阳性菌以表皮葡萄球菌(260株,10%)和金黄色葡萄球菌(177株,6.8%)为主,其对克林霉素、红霉素、苯唑西林的耐药率均>50%。革兰阴性菌中以大肠埃希菌(572株,22%)和肺炎克雷伯菌(238株,9.2%)最为常见,对头孢呋辛、哌拉西林及复方新诺明耐药率>52%; 对碳青霉烯类抗生素耐药率<2.4%。结论 血培养分离出的病原菌以革兰阴性为主,临床应加强血流感染的耐药监测,合理用药。
Abstract:
Objective To explore the distribution and drugresistance of 2 599 strains of pathogenic bacteria cultured in shaanxi ProvencePeople's Hospital from 2015 to 2017 so as to provide guidance for the clinicaldiagnosis and treatment.Methods 2 599 specimens of bloodculture were collected from 2015 to 2017,according to 2016 standards of American Clinical and Laboratory Standards Institute(CLSI),data were analyzed with WHONET 5.6 and SPSS17.0 software.Results Total of 2 599strains of pathogens were isolated.About pathogens 1 141 specimens were gram-positive bacteria strains accounting for 43.9%,1 282 specimens were gram-negative bacteria strains,accounting for 49.3%.176 strains of fungi accounting for 6.8%.Positive pathogens were mainly distributed in ICU(n=425,16.4%),neonatology department(n=188,7.2%),emergency surgery(n=216,8.3%),respiratory medicine(n=199,7.7%)and hepatobiliary surgery(n=185,7.1%).There was seasonal distribution of the positive bacteria rate in blood culture,which was higher in summer than in other seasons.Gram-positive bacteria were mainly on Staphylococcus epidermidis(n=260,10%)and Staphylococcus aureus(n=177,6.8%),the drug resistance of them to clindamycin,erythromycin and oxacillin were all>50%.The great majority of gram-negative bacteria was Escherichia coli(n=572,22%)and Klebsiella pneumonia(n=238,9.2%),the resistance rates of them to cephalosporins,piperacillinand sulfamethoxazole were >52%,and the resistance rate of E.coli to carbapenems was less than 2.5%.Conclusion The Gram-negativebacilli took the major part of the positive blood culture of the hospital.Escherichia coli were the main pathogenic bacteria.The clinical should strengthen the drug resistance monitoring of the pathogenic bacteria from blood and rationally use drugs.

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备注/Memo

备注/Memo:
作者简介:王 晶(1987-),女,硕士,中级检验师,研究方向:临床微生物,E-mail:wangjingjianyan@126.com。 通讯作者:李小侠(1976-),女,本科,主管检验师,研究方向:临床微生物,E-mail:lixiaoxiamrr@163.com。收稿日期:2018-12-04 修回日期:2019-05-20
更新日期/Last Update: 2019-07-30