[1]王结珍,梁培松,王伟佳,等.孕早期血清F-βHCG,PAPPA水平及BMI值的变化与不良妊娠结局的相关性[J].现代检验医学杂志,2019,34(04):151-153.[doi:10.3969/j.issn.1671-7414.2019.04.037]
　WANG Jie-zhen,LIANG Pei-song,WANG Wei-jia,et al.Correlation of the Change of Early Pregnancy Serum F-βHCG,PAPPA,BMI and Adverse Pregnancy Outcomes[J].Journal of Modern Laboratory Medicine,2019,34(04):151-153.[doi:10.3969/j.issn.1671-7414.2019.04.037]
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孕早期血清F-βHCG,PAPPA水平及BMI值的变化与不良妊娠结局的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
151-153
栏目:
检验与临床
出版日期:
2019-08-20

文章信息/Info

Title:
Correlation of the Change of Early Pregnancy Serum F-βHCG,PAPPA,BMI and Adverse Pregnancy Outcomes
文章编号:
1671-7414(2019)04-151-04
作者:
王结珍; 梁培松; 王伟佳; 梁艮英
(中山大学附属中山医院检验医学中心,广东中山 528403)
Author(s):
WANG Jie-zhen; LIANG Pei-song; WANG Wei-jia; LIANG Gen-ying
(Center of Laboratorial Medicine, Sun Yat-sen University Affiliated Zhongshan Hospital,Guangdong Zhongshan528403,China)
关键词:
妊娠结局;  身体质量指数;  游离β人绒毛膜促性腺激素;  妊娠相关血浆蛋白A
分类号:
R714.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.04.037
文献标志码:
A
摘要:
目的 探讨孕妇孕早期游离β人绒毛膜促性腺激素(F-βHCG)和妊娠相关血浆蛋白A(PAPPA)水平及体质量指数(BMI)值的变化与不良妊娠结局的相关性。方法 收集1 152例定期进行产前检查并顺利分娩的孕妇资料,记录孕妇孕期BMI值、孕期检查结果、并发症、妊娠结局和新生儿出生情况; 分析孕妇孕早期PAPPA,F-βHCG和BMI值与不良妊娠结局的相关性。结果 孕期BMI的增长与妊娠期糖尿病呈负相关(r=-0.223,P=0.000),与妊娠期高血压和巨大儿呈正相关(r=0.061,0.062,P=0.038,0.035); 孕早期血清PAPPA水平与妊娠期糖尿病、胎儿生长受限及足月低体重儿呈负相关(r=-0.102～-0.082,P=0.001～0.006); 孕早期血清F-βHCG水平与胎膜早破发生呈正相关(r=0.066,P=0.025)。结论 孕妇孕期BMI值的异常增长,以及孕早期PAPPA水平过低和F-βHCG水平过高均会增加不良妊娠结局的风险。
Abstract:
Objective To evaluate the correlation of the change of early pregnancy F-βHCG,PAPPA,BMI and adverse pregnancy outcomes.Methods The data of 1 152 pregnant women who received regular antenatal examination and delivery were collected,and the vaule of BMI,testresult,complications,pregnant outcome and neonatal status during pregnancy were recorded; the correlation of the change of F-βHCG,PAPPA,BMI and adverse pregnancy outcomes were analyzed.Results There was a negative correlation between the BMI growth during pregnancy with gestational diabetes mellitus(r=-0.223,P=0.000),and were a positive correlation with gestational hypertension and macrosomia(r=0.061,0.062,P=0.038,0.035).Early pregnancy serum PAPPA level was negatively correlated with gestational diabetes,fetal growth restriction and term low birth weight(r=-0.102～-0.082,P=0.001～0.006),and early pregnancy serum F-βHCG level was positively correlated with premature rupture of membranes(r=0.066,P=0.025).Conclusion The pregnant women BMI abnormal growth?during pregnancy,low level PAPPA and high level F-βHCG will increase the risk of adverse pregnancy outcomes.

参考文献/References:

[1] 王晶晶,王鑫,陈书强,等.孕前BMI与妊娠结局及胎盘转运效率的关系[J].中国妇幼健康研究,2018,29(6):702-705. WANG Jingjing,WANG Xin,CHEN Shuqiang,et al.Associations of maternal pre-pregnancy body mass index with pregnancy outcome and placental transport efficiency[J].Chinese Journal of Woman and Child Health Research,2018,29(6):702-705. [2] 丁小莉,陈兰,钟燕.初产妇孕期BMI及孕中期血清AFP,β-HCG,uE3水平对不良妊娠结局的影响[J].贵州医科大学学报,2017,42(4):490-494. DING Xiaoli,CHEN Lan,ZHONG Yan.Effect of BMI during pregnancy,serum AFP,β-HCG,uE3 levels during second trimester of primipara on adverse pregnancy outcomes[J].Journal of Guizhou Medical University,2017,42(4):490-494. [3] 张妍,张兰梅,周玲,等.超重孕妇孕期体重增长与妊娠结局关系的探讨[J].中国实验诊断学,2018,22(2):269-271. ZHANG Yan,ZHANG Lanmei,ZHOU Ling,et al.Relationship between weight gain during pregnancy and pregnancy outcome in overweight pregnant women[J].Chin J Lab Diagn,2018,22(2):269-271. [4] 刘银春,朱丽英,黄映春,等.不同孕前体重指数及孕期体重指数增长对妊娠结局的影响[J].吉林医学,2018,39(3):423-425. LIU Yinchun,ZHU Liying,HUANG Yingchun,et al.Effects of different pre pregnancy body mass index and maternal body mass changes on pregnancy outcomes[J].Jilin Medical Journal,2018,39(3):423-425. [5] 钟利若,张立军,陈淑芳.孕前肥胖与妊娠不良结局的相关性探讨[J].临床和实验医学杂志,2016,15(10),1020-1022. ZHONG Liruo,ZHANG Lijun,CHEN Shufang.Effe-ct of pre-pregnancy body mass index on adverse pregnancy outcomes[J].Journal of Clinical and Experimental Medicine,2016,15(10),1020-1022. [6] 陈晓璐,彭洋颖,徐雪清.妊娠不同时期体重增长与妊娠结局关系的研究[J].中华医学杂志,2018,98(19):1493-1497. CHEN Xiaolu,PENG Yangying,XU Xueqing.Study on weight gain in different stages of pregnancy and pregnancy outcomes[J].National Medical Journalof China,2018,98(19):1493-1497. [7] 柯雁飞,吕翠芬,刘媛媛,等.孕期营养体重管理与预防巨大儿及足月低体重儿的临床研究[J].心电图杂志(电子版),2018,7(4):136-138. KE Yanfei,L(¨overU)Cuifen,LIU Yuanyuan,et al.Nutritional weight management during pregnancy and prevention of macrosomia and full-term low weight children[J].Journal of Electrocardiogrm(Electronic Edition),2018,7(4):136-138.[8] CABALLERO SANZ S,NOZALEDA PASTOR G,GARCIA-TIZON LARROCA S.First-trimester biochemical screening for low birth weight:clinical effectiveness of low pregnancy-associated plasma protein-A and high thyroid-stimulating hormone[J].Clin Lab,2018,64(9):1501-1508. [9] LIVRINOVA V,PETROY L,SAMARDZISKI L,et al.Obstetric outcome in pregnant patients with low level of pregnancy-associated plasma protein A in first trimester[J].Open Access Maced J Med Sci,2018,6(6):1028-1031. [10] 沈亲亲,张檀.孕中期血清产前筛查指标mom值异常与不良妊娠结局的相关性[J].浙江医学,2016,38(3):195-197,200. SHEN Qinqin,ZHANG Tan.Relationship between second-trimester maternal serum triple screening markers and adverse pregnancy outcomes[J].Zhejiang Medical Journal,2016,38(3):195-197,200. [11] 赵丽,肖建平,杨岚,等.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局分析[J].中国全科医学,2015,18(27):3304-3307. ZHAO Li,XIAO Jianping,YANG Lan,et al.Analysis of pregnancy outcome ofwomen with increased HCG level in Down's screening[J].Chinese General Practice,2015,18(27):3304-3307.

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备注/Memo

备注/Memo:
基金项目:2017年度中山市社会公益科技研究专项资金立项项目。 作者简介:王结珍(1985-),女,本科,主管技师,专业:临床基础检验,E-mail:wanglei8511@163.com。收稿日期:2019-02-18 修回日期:2019-03-25
更新日期/Last Update: 2019-07-30