[1]谭洪辉,邱振华,萧 飞,等.多项血清自身免疫抗体及红细胞分布宽度对自身免疫性肝炎鉴别诊断价值分析[J].现代检验医学杂志,2020,35(02):28-31.[doi:10.3969/j.issn.1671-7414.2020.02.009]
 TAN Hong-hui,QIU Zhen-hua,XIAO Fei,et al.Value of Multiple Serum Autoantibodies and Red Blood Cell DistributionWidth in Differential Diagnosis of Autoimmune Hepatitis[J].Journal of Modern Laboratory Medicine,2020,35(02):28-31.[doi:10.3969/j.issn.1671-7414.2020.02.009]
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多项血清自身免疫抗体及红细胞分布宽度对自身免疫性肝炎鉴别诊断价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
28-31
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Value of Multiple Serum Autoantibodies and Red Blood Cell DistributionWidth in Differential Diagnosis of Autoimmune Hepatitis
文章编号:
1671-7414(2020)02-028-04
作者:
谭洪辉1邱振华1萧 飞2龙则平1
(1. 高州市人民医院检验科,广东高州 525200;2. 茂名市人民医院检验科,广东茂名 525000)
Author(s):
TAN Hong-hui1 QIU Zhen-hua2 XIAO Fei2 LONG Ze-ping1
(1. Department of Clinical Laboratory , People’s Hospital of Gaozhou City, Guangdong Gaozhou 525200,China;2.Department of Clinical Laboratory, Maoming Peple’s Hospital, Guangdong Maoming 525000, China)
关键词:
自身免疫抗体红细胞分布宽度鉴别诊断自身免疫性肝炎
分类号:
R575.1;R392.11
DOI:
10.3969/j.issn.1671-7414.2020.02.009
文献标志码:
A
摘要:
目的 探讨联合检测多项血清自身免疫抗体及红细胞分布宽度(red blood cell distribution width ,RDW)对自身免疫性肝炎(autoimmune hepatitis,AIH)鉴别诊断价值。方法 检测73 例AIH 组、80 例病毒性肝炎(viral hepatitis,VH 组)和80 例对照的血细胞检测和4 项自身免疫抗体[ 包括抗肝特异性胞浆抗原I 型抗体(anti hepatospecific cytoplasmicantigen type I antibody,LC1),抗核抗体(antinuclear antibody,ANA),抗平滑肌抗体(anti smooth muscle antibody, ASMA)和抗可溶性肝抗原/ 抗肝胰抗原抗体(anti soluble liver antigen / anti hepatopancreas antigen antibody,SLA/LP)],比较三组4 项自身抗体的阳性率及RDW 水平差异,并分析三组ANA 抗体滴度及核型。结果 AIH 患者4 项自身免疫抗体阳性率分别为LC 12.7%,ANA 64.4%,ASMA 58.9% 和SLA/LP 27.4%,其中ANA,ASMA,SLA/LP 与非AIH 患者比较差异有统计学意义(P<0.05);AIH 患者中ANA 以高滴度(≥ 1∶320) 核颗粒型和核均质型为主,与非AIH 患者比较滴度(≥ 1∶320)及核型(核颗粒型和核均质型)差异均有统计学意义(P<0.05);AIH 组患者RDW 水平为14.65%±2.01%,与非AIH 患者差异有统计学意义(P<0.05)。结论 4 项血清自身免疫抗体及RDW 联合检测对AIH具有鉴别诊断价值。

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备注/Memo

备注/Memo:
基金项目:广东省茂名市科学技术计划项目( 编号: 2017173)。作者简介:谭洪辉(1984-),男,学士学位,副主任技师,研究方向为临床检验,E-mail:thh3136@163.com。通信作者:萧飞,副主任技师,E-mail:499569411@qq.com。收稿日期:2019-11-11修回日期:2020-01-10
更新日期/Last Update: 2020-04-30