[1]刘静娟,李　越,何　谦,等.陕西地区RhD 阴性儿童患者Rh 表型分布特征研究[J].现代检验医学杂志,2020,35(03):66-68.[doi:10.3969/j.issn.1671-7414.2020.03.016]
　LIU Jing-juan,LI Yue,HE Qian,et al.Distribution of RhD Phenotypes among RhD-negative Children Patients in Shaanxi Province[J].Journal of Modern Laboratory Medicine,2020,35(03):66-68.[doi:10.3969/j.issn.1671-7414.2020.03.016]
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陕西地区RhD 阴性儿童患者Rh 表型分布特征研究 ()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
66-68
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Distribution of RhD Phenotypes among RhD-negative Children Patients in Shaanxi Province
文章编号:
1671-7414（2020）03-066-03
作者:
刘静娟1; 2; 李　越1; 何　谦1; 周晓艳1; 尹　阳1; 肖姗姗1
（1. 西安交通大学第二附属医院检验科，西安　710004；2. 西安交通大学附属儿童医院输血科，西安　710003）
Author(s):
LIU Jing-juan1; 2;  LI Yue1;  HE Qian1;  ZHOU Xiao-yan1; YIN Yang1;  XIAO Shan-shan1
（1. Department of Clinical Laboratory, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China; 2. Department of Blood Transfusion, Children’s Hospital Affiliated to Xi’an Jiaotong University, Xi’an 710003, China）
关键词:
儿童; RhD 阴性; 表型分布
分类号:
R457.1
DOI:
10.3969/j.issn.1671-7414.2020.03.016
摘要:
目的　了解陕西地区RhD 阴性儿童血型表型的多态性，为儿童输血提供科学安全的参考依据。方法　随机选 取2018 年9 月~2019 年4 月于西安交通大学附属儿童医院就诊的59 582 例儿童血细胞检测标本，采用试管法检测RhD 抗原。筛选的RhD 阴性标本用间接抗人球蛋白法进行确认，并调查其C，c，E，e 抗原表现型频率。结果　检出RhD 阴性儿童269 例，Du 2 例，陕西地区儿童患者RhD 阴性率为4.48‰，其中男性147 例，女性120 例。不同性别的RhD 阴性儿童患者的ABO 血型构成比不全相同。继续深入分析2019 年1 ~ 4 月期间就诊的儿童患者中，91 例确认的RhD 阴性标本ccee 的表型频率为46.15%（42/91），Ccee 为40.66%（37/91），ccEe 为6.59%（6/91），CCee 为4.40%（4/91）， CcEe 为1.10%（1/91）和ccEE 为1.10%（1/91）。结论　陕西地区RhD 阴性儿童患者中，B 型男性人群多于女性，A 型女性人群多于男性。Rh 表现型以ccee 和Ccee 为主，CcEe 和ccEE 表型频率最低，Rh 血型表型分布研究对促进临床 儿童输血安全具有重要意义。
Abstract:
Objective　To explore the serological distribution polymorphism of Rh phenotypes in RhD negative children patients in Shaanxi Province, weaimed to provide a scientific and safe reference for children’s blood transfusion. Methods　Randomly selected 59 582 children’s blood samples from Children’s Hospital of Xi’an Jiaotong University from 2018-9 to 2019-4, and they were tested for RhD antigen by test tube method. Screening of RhD-negative specimens was confirmed by indirect antihuman globulin method, and the frequency of C, c, E, e antigen phenotype was determined. Results　269 RhD-negative children patients and 2 Du were detected, and the RhD-negative rate of children patients in Shaanxi was 4.48%, including 147 males and 120 females. There were the significant differences in ABO blood group composition ratios for RhD-negative children with different sex. Continued to analyze recent 91 cases of confirmed RhD-negative children patients from the period of 2019-1 to 2019-4, in which the phenotype frequency of ccee was 46.15% (42/91), Ccee was 40.66% (37/91), ccEe was 6.59% ( 6/91), CCee was 4.40% (4/91), CcEe was 1.10% (1/91), and ccEE was 1.10% (1/91), respectively. Conclusion　Among children patients with RhD-negative type in Shaanxi Province, male B blood group individuals were more than female and female A blood patients were more than male. The serological phenotype of Rh was mainly ccee and Ccee,andthe CcEe and ccEE phenotype was the lowest, providinga great clinical significance for safe blood transfusion in clinical RhD-negative children.

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备注/Memo

备注/Memo:
收稿日期：2019-12-26 修回日期：2020-02-01作者简介：刘静娟（1984-），女，硕士研究生，从事输血方面相关研究，E-mail: 13572968932@163.com。 通讯作者：何谦（1971-），女，博士，主任技师，从事医学检验工作及研究，E-mail: qianh0511@163.com
更新日期/Last Update: 2020-07-20