[1]周 红,娜日罕,荣 钰,等.扩张型心肌病患者两种治疗方法前后microRNA-126 和microRNA-30a 水平表达的研究[J].现代检验医学杂志,2020,35(04):6-9.[doi:10.3969/j.issn.1671-7414.2020.04.002]
　ZHOU Hong,NA Ri-han,RONG Yu,et al.Study on the Expression of MicroRNA-126 and Microrna-30a in Patients with Dilated Cardiomyopathy before and after Two Treatments[J].Journal of Modern Laboratory Medicine,2020,35(04):6-9.[doi:10.3969/j.issn.1671-7414.2020.04.002]
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扩张型心肌病患者两种治疗方法前后microRNA-126 和microRNA-30a 水平表达的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
6-9
栏目:
论　著
出版日期:
2020-09-05

文章信息/Info

Title:
Study on the Expression of MicroRNA-126 and Microrna-30a in Patients with Dilated Cardiomyopathy before and after Two Treatments
文章编号:
1671-7414（2020）04-006-04
作者:
周 红; 娜日罕; 荣 钰; 董 莉
（内蒙古医科大学附属医院检验科, 呼和浩特 010050）
Author(s):
ZHOU Hong; NA Ri-han; RONG Yu; DONG Li
(Department of Clinical Laboratory,the Affiliated Hospital of Inner Mongolia Medical University,Hohehot 010050,China)
关键词:
扩张型心肌病; 微小核糖核酸-126; 微小核糖核酸-30a
分类号:
R542.2；R392.11
DOI:
10.3969/j.issn.1671-7414.2020.04.002
文献标志码:
A
摘要:
目的 探讨microRNA-126（miRNA-126） 和microRNA-30a(miRNA-30a) 检测在扩张型心肌病（dilatedcardiomyopathy，DCM）患者诊断及预后评估的价值。方法 收集2014.2 ～ 2019.3 期间40 例DCM 患者，按治疗方法分为手术治疗组20 例和一般治疗组20 例，同期健康体检者20 例为对照组，采用qRT-PCR 法?检测治疗前后患者血清中miRNA-126 和miRNA-30a 的相对含量，并进行统计学分析。结果 ① DCM 患者与对照组血清miRNA-126 相对表达量为[1.40(0.44，3.28) vs 1.15（0.44，2.25）]，miRNA-30a 为[2.37(0.70，4.25) vs 1.05（0.48，2.20）]，差异无统计学意义（Z=-0.557，-1.662，P ＞ 0.05）。②治疗后，一般治疗组miRNA-126 为 1.35(0.66，2.00)，miRNA-30a 为1.2(0.77，4.55)。手术治疗组miRNA-126 为 0.16(0.10，0.26)，miRNA-30a 为0.20(0.14，0.33)， 手术治疗组治疗前后miRNA-126，miRNA-30a 表达量差异有统计学意义（均Z =-3.059，均P ＜ 0.05）。一般治疗及手术治疗两者表达量差异有统计学意义（miRNA-126：Z = -3.806，P ＜ 0.05；miRNA-30a：Z = -3.24，P ＜ 0.05）。③ miRNA-126 与NT-proBNP 呈负相关；循环miRNA-30a 与NT-proBNP 呈正相关，与射血分数呈负相关。④ miRNA-126 的12 个月相对危险度为 0.768（95%CI 0.431~1.37，P ＞ 0.05），miRNA-30a 的12 个月生存分析其相对危险度为1.141（95% CI 0.775~1.678，P ＞ 0.05）。结论 miRNA-126 和miRNA-30a 可为两种不同治疗方法的评价提供一定的参考价值。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2020-02-20修回日期：2020-07-10基金项目：内蒙古自治区自然基金（2017MS0826）内蒙古科技计划基金（NMKJZD20170742）。作者简介：周红（1994-），女，硕士，研究方向：心血管疾病相关检验。通讯作者：董莉，女，硕士生导师，研究方向：心血管疾病相关检验，E-mail: dongsuanzhi@163.com。
更新日期/Last Update: 2020-10-08