[1]宋　丽,杜宁超,李富荣.儿童慢性 ITP 外周血 CD3 + T 细胞活性氧的检测及临床意义[J].现代检验医学杂志,2020,35(06):144-148.[doi:doi:10.3969/j.issn.1671-7414.2020.06.035]
　SONG Li,DU Ning-chao,LI Fu-rong.Detection and Clinical Significance of CD3 + T Cell Reactive OxygenSpecies in Peripheral Blood of Children with Chronic ITP[J].Journal of Modern Laboratory Medicine,2020,35(06):144-148.[doi:doi:10.3969/j.issn.1671-7414.2020.06.035]
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儿童慢性 ITP 外周血 CD3 + T 细胞活性氧的检测及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
144-148
栏目:
研究简报·实验技术
出版日期:
2020-12-30

文章信息/Info

Title:
Detection and Clinical Significance of CD3 + T Cell Reactive OxygenSpecies in Peripheral Blood of Children with Chronic ITP
文章编号:
1671-7414（2020）06-144-05
作者:
宋　丽1 ; 杜宁超2 ; 李富荣1
（1. 深圳市人民医院转化医学协同创新中心，广州 深圳 518020；2. 深圳市第二人民医院肛肠外科，广州 深圳 518035）
Author(s):
SONG Li 1 ;  DU Ning-chao 2 ;  LI Fu-rong
(1. Collaborative Innovation Center of Translational Medicine, Shenzhen People’s Hospital,Guangzhou Shenzhen510020, China;2. Anorectal Surgery, the Second People’s Hospital of Shenzhen, Guangzhou Shenzhen 518035, China)
关键词:
儿童; 特发性血小板减少性紫癜（ITP）; CD3 + T 细胞; 活性氧 (ROS)
分类号:
R725.5；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.035
文献标志码:
A
摘要:
目的　探讨儿童慢性特发性血小板减少性紫癜 (Idiopathic thrombocytopenic purpura，ITP) 外周血 CD3+ T 细胞中活性氧 (reactive oxygen species, ROS) 含量及其与血小板的关系，为临床诊断和治疗提供依据。方法　随机收集 30 例慢性 ITP患儿外周血为试验组，30 例健康儿童外周血为对照组，用流式细胞术检测外周血 CD3 + T 细胞和 ROS 平均荧光强度，进行统计学分析。结果　试验组CD3 + T细胞ROS平均荧光强度（15.98±5.78）明显高于对照组ROS平均荧光强度（4.65±1.03），两组间 ROS 的差异有统计学意义（t=2.956，P ＜ 0.05）；试验组 CD3 + T 细胞 ROS 与血小板成负性相关关系。结论　慢性ITP 患儿外周血 CD3 + T 细胞的 ROS 明显高于对照组，说明 ROS 可以为儿童慢性 ITP 的诊断及治疗提供一定的参考依据。

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更新日期/Last Update: 2020-12-20