[1]徐翠香,王建华,武 敏,等.胃癌患者血清CA724,NSE和 PGR水平联合检测对肿瘤临床病理分期及淋巴结转移的诊断价值[J].现代检验医学杂志,2021,36(01):6-9.[doi:10.3969/j.issn.1671-7414.2021.01.002]
 XU Cui-xiang,WANG Jian-hua,WU Min,et al.Diagnostic Value of Combined Detection of Serum CA724, NSE and PGR Levels in Patients with Gastric Cancer for Tumor Clinical Pathological Stage and Lymph Node Metastasis[J].Journal of Modern Laboratory Medicine,2021,36(01):6-9.[doi:10.3969/j.issn.1671-7414.2021.01.002]
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胃癌患者血清CA724,NSE和 PGR水平联合检测对肿瘤临床病理分期及淋巴结转移的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
6-9
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Diagnostic Value of Combined Detection of Serum CA724, NSE and PGR Levels in Patients with Gastric Cancer for Tumor Clinical Pathological Stage and Lymph Node Metastasis
文章编号:
1671-7414(2021)01-006-05
作者:
徐翠香王建华武 敏
(陕西省人民医院 a.陕西省感染与免疫重点实验室;b.普外科;c.科研科;d.血液病研究室,西安 710068)
Author(s):
XU Cui-xiangWANG Jian-hua WU Min et al
(a.Shaanxi Provincial Key Laboratory of Infection and Immune Diseases; b.Department of General Surgery;c.Scientific Research Center; d.Laboratory of Hematology, Shaanxi Provincial People’s Hospital, Xi’an 710068,China)
关键词:
血清糖类抗原 724神经元特异性烯醇化酶胃蛋白酶原比值胃癌诊断效能
分类号:
R735.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.01.002
文献标志码:
A
摘要:
目的 探讨血清糖类抗原 724(CA724)、神经元特异性烯醇化酶( NSE)和胃蛋白酶原比值( PGR)在胃癌诊断、临床分期及淋巴结转移中的临床应用价值。方法 采用电化学发光法及酶联免疫吸附法( ELISA)测定 2017年 4月 ~2019年 4月入住于陕西省人民医院的 84例胃癌患者(胃癌组)及 80例胃良性病变患者(良性病变组)血清中 CA724,NSE和 PGR水平,观察上述指标在各组患者中的表达水平,评价其在胃癌临床分期和淋巴结转移中的应用价值,并分析这三项指标联合检测的诊断效能。结果 胃癌组血清 CA724和 NSE水平与良性病变组对比,明显较高, PGR水平与良性病变组对比,明显较低,差异均有统计学意义( t=63.327,48.026,7.146,均 P< 0.05);胃癌组中, III~IV期患者血清 CA724和 NSE水平与 I~II期患者对比,明显较高, PGR水平与 I~II期患者对比,明显较低,差异均有统计学意义( t=46.687,47.916,16.358,均 P< 0.05);胃癌组中,淋巴结转移者血清 CA724和 NSE水平与未转移者对比,明显较高, PGR水平与未转移者对比,明显较低,差异均有统计学意义( t=49.679,30.872,22.573,均 P< 0.05); CA724, NSE和 PGR三项联合检测准确度、特异度、灵敏度分别为 92.68%, 88.75%和 96.43%,与单项检测对比,均明显较高,差异均有统计学意义(χ2=5.096~20.993,均 P< 0.05)。结论 CA724, NSE 和 PGR在胃癌患者中表达异常,且与胃癌临床分期及淋巴结转移有一定关联,三者联合检测,有助于胃癌的鉴别诊断。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年基金项目:干扰素 α增强 HCA587长肽疫苗的抗肿瘤效应及机制研究,项目批准号: 81801647;陕西省创新能力支撑计划 (2017KCT-28)。
作者简介:徐翠香 (1980-),女,西安交通大学第一附属医院内科学博士,主治医师,研究方向:肿瘤免疫及耐受, E-mail:xucuixiang1129@163.com。
通讯作者:黄晓燕(1983-),女,硕士,主管技师,研究方向:肿瘤诊断与免疫, E-mail:huangxy08@163.com。
更新日期/Last Update: 2021-02-05