[1]闫海燕,杨云秀,杨云华,等.慢性阻塞性肺疾病患者 Nrf2 基因多态性与肺功能及临床病情判断的相关性研究[J].现代检验医学杂志,2021,36(03):27-31.[doi:10.3969/j.issn.1671-7414.2021.03.007]
 YAN Hai-yan,YANG Yun-xiu,YANG Yun-hua,et al.Study on Relevance of Nrf2 Gene Polymorphism with Pulmonary Functionand Clinical Condition Judgment in Patients with Chronic ObstructivePulmonary Disease[J].Journal of Modern Laboratory Medicine,2021,36(03):27-31.[doi:10.3969/j.issn.1671-7414.2021.03.007]
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慢性阻塞性肺疾病患者 Nrf2 基因多态性与肺功能及临床病情判断的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
27-31
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Study on Relevance of Nrf2 Gene Polymorphism with Pulmonary Functionand Clinical Condition Judgment in Patients with Chronic ObstructivePulmonary Disease
文章编号:
1671-7414(2021)03-027-05
作者:
闫海燕杨云秀杨云华
(1. 咸阳市第一人民医院呼吸与危重症医学科 , 陕西咸阳 712000;2. 陕西唐华四棉医院呼吸科,西安 710038;3. 西安北车医院内科,西安 710085)
Author(s):
YAN Hai-yan1 YANG Yun-xiu2 YANG Yun-hua3 SONG Xiao-wei1 GOU Jian1
(1.Department of Respiratory and Critical Care Medicine, the First People’s Hospital of Xianyang City, ShaanxiXianyang 712000,China;2.Department of Respiratory, Shaanxi Tanghua Simian Hospital, Xi’an 710038 China;3.Department of Internal Medicine, Xi’an Beiche Hospital, Xi’an 710085, China )
关键词:
核因子相关因子 2基因多态性慢性阻塞性肺疾病病情判断
分类号:
R563;Q786
DOI:
10.3969/j.issn.1671-7414.2021.03.007
文献标志码:
A
摘要:
目的 研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)患者核因子相关因子 2(nuclearfactor erythroid-2-related factor2, Nrf2)基因多态性与肺功能及临床病情判断的相关性。方法 收集 2018 年 6 月~ 2020年 6 月 78 例 COPD 患者作为研究对象,采用聚合酶链反应 - 限制性片段长度多态性(polymerase chain reaction restrictionfragment length polymorphism, PCR-RFLP)法检测 Nrf2-617C/A(rs6721961)位点基因型分布。比较不同肺功能分级患者 Nrf2-617C/A(rs6721961)基因型,分析 Nrf2-617C/A(rs6721961)基因型分布与治疗效果的关系。结果 78 例患者显效 48 例,有效 17 例和无效 13 例,有效率 83.33%。Nrf2 基因多态性检测结果显示 CC 型 20 例,CA 型 30 例,AA 型28 例。不同疗效 COPD 患者 Nrf2 基因型分布比较,差异有统计学意义(P<0.05)。不同 Nrf2 基因型 COPD 患者肺功能分级比较,差异有统计学意义(χ2=15.452,P<0.05)。治疗前和治疗后不同 Nrf2 基因型 COPD 患者用力肺活量(forcedvital capacity, FVC),一秒钟用力呼气量(forced expiratory volume in one second, FEV1%),FEV1/FVC及最大通气量(maximalventilation volume, MVV)水平比较,差异均有统计学意义(P<0.05)。受试者工作曲线(receiver operator characteristic,ROC) 分 析 显 示,Nrf2 基因多态性对判断 COPD 治疗效果的 AUC 为 0.796(SE=0.056,95%CI=0.687 ~ 0.905,P<0.001),敏感度 0.767,特异度为 0.729。结论 Nrf2 基因多态性与 COPD 病情相关,其有助于预测临床治疗效果,具有较高应用价值。

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备注/Memo

备注/Memo:
作者简介:闫海燕(1983-),女,本科,主治医师,研究方向:呼吸重症,肺心病,肺部感染, E-mail:xianyyanhaiy@163.com。
通讯作者:宋晓伟(1987-),男,本科,研究方向:气道肿瘤,E-mail:415510359@qq.com。
更新日期/Last Update: 1900-01-01