[1]洪雄新,李观强,杨 辉,等.2 型糖尿病患者ABCA1 R219K 基因多态性分布及其与血脂水平的相关性研究[J].现代检验医学杂志,2020,35(04):14-17.[doi:10.3969/j.issn.1671-7414.2020.04.004]
 HONG Xiong-xin,LI Guan-qiang,YANG Hui,et al.Study on Distribution of ABCA1 R219K Gene Polymorphism and Its Correlation with Blood Lipid Levels for Type 2 Diabetes Mellitus Patients[J].Journal of Modern Laboratory Medicine,2020,35(04):14-17.[doi:10.3969/j.issn.1671-7414.2020.04.004]
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2 型糖尿病患者ABCA1 R219K 基因多态性分布及其与血脂水平的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
14-17
栏目:
论 著
出版日期:
2020-09-05

文章信息/Info

Title:
Study on Distribution of ABCA1 R219K Gene Polymorphism and Its Correlation with Blood Lipid Levels for Type 2 Diabetes Mellitus Patients
文章编号:
1671-7414(2020)04-014-04
作者:
洪雄新李观强杨 辉李小峰万彦彬郭中秋杨素珍
(深圳市龙岗区人民医院,广东深圳 518172)
Author(s):
HONG Xiong-xinLI Guan-qiangYANG HuiLI Xiao-fengWAN Yan-binGUO Zhong-qiuYANG Su-zhen
(Longgang District People’s Hospital of Shenzhen,Guangdong Shenzhen 518172,China)
关键词:
2 型糖尿病三磷酸腺苷结合盒转运子A1R219K基因多态性血脂
分类号:
R587.1;Q503
DOI:
10.3969/j.issn.1671-7414.2020.04.004
文献标志码:
A
摘要:
目的 研究三磷酸腺苷结合盒转运子A1(ABCA1) R219K 基因多态性在2 型糖尿病(T2DM)患者中的分布情况,探讨其与2 型糖尿病患者血脂的关系。方法 选取2015 年12 月~ 2017 年4 月期间深圳市龙岗区人民医院收治的85 例T2DM 患者和90 例健康体检对照组纳入研究,对两组研究对象进行血液标本采集,采用聚合酶链反应(PCR)- 限制性片段长度多态性(RFLP)检测ABCA1 R219K 等位基因和基因型频率情况,对比两组患者血脂水平以及研究组不同基因型患者血脂水平情况,进一步探讨T2DM 患者ABCA1 R219K 基因多态性及其与血脂水平的关系。结果 两组研究对象TC,TG,HDL-C 和LDL-C 水平对比差异均无统计学意义(t=0.191,0.853,0.755 和0.597,均P>0.05)。两组研究对象ABCA1 R219K 等位基因和基因型频率对比差异均无统计学意义(t=0.860,2.393,均P>0.05)。ABCA1R219K 等位基因三种基因型之间TC,TG 和LDL-C 水平差异无统计学意义(F=0.02,0.14,2.00 和0.06,P>0.05);KK 基因型HDL-C 水平明显高于RR 和RK 基因型,差异有统计学意义(t=2.543 和2.630,P<0.05);RR 和RK 基因型之间HDL-C 水平差异无统计学意义(t=0.238,P>0.05)。结论 ABCA1 R219K 基因多态性并不是T2DM 发病的遗传学标志,但其变异参与了T2DM 患者脂代谢异常的调节。

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备注/Memo

备注/Memo:
收稿日期:2020-03-16修回日期:2020-04-22作者简介:洪雄新(1982-),男,本科学士,主管技师,主要从事急诊实验室检验工作,E-mail:191296160@qq.com。
更新日期/Last Update: 2020-10-08