[1]饶向东,刘振宇,汤红亮,等.胃癌患者血清miR-181b和PDCD4水平表达与幽门螺杆菌感染的关系[J].现代检验医学杂志,2021,36(04):1-4.[doi:10.3969/j.issn.1671-7414.2021.04.001]
 RAO Xiang-dong,LIU Zhen-yu,TANG Hong-liang,et al.Relationship between the Expression of miR-181b, PDCD4 and Helicobacter Pylori Infection in Patients with Gastric Cancer[J].Journal of Modern Laboratory Medicine,2021,36(04):1-4.[doi:10.3969/j.issn.1671-7414.2021.04.001]
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胃癌患者血清miR-181b和PDCD4水平表达与幽门螺杆菌感染的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
1-4
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Relationship between the Expression of miR-181b, PDCD4 and Helicobacter Pylori Infection in Patients with Gastric Cancer
文章编号:
1671-7414(2021)04-001-05
作者:
饶向东1刘振宇1汤红亮1张 慧1白 雪2项梦琦2谢瑞霞2徐 龙2
(1.湖北省孝昌县第一人民医院消化内科,湖北孝感 432900; 2.深圳大学总医院消化内科,深圳大学临床科学研究院,深圳大学国际肿瘤中心,广东深圳 518055)
Author(s):
RAO Xiang-dong1 LIU Zhen-yu1 TANG Hong-liang1 ZHANG Hui1 BAI Xue2 XIANG Meng-qi2 XIE Rui-xia2 XU Long2
(1.Department of Gastroenterology, the First People’s Hospital of Xiaochang County, Hubei Xiaogan 432900, China;2 . Department of Gastroenterology, Shenzhen University General Hospital,Institute of Clinical Sciences, Shenzhen University,International Cancer Center, Shenzhen University,Guangdong Shenzhen 518055,China )
关键词:
胃癌miR-181b程序性细胞死亡因子4幽门螺杆菌
分类号:
R735.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.04.001
文献标志码:
A
摘要:
目的 探讨胃癌患者血清中miR-181b,程序性细胞死亡因子4(PDCD4)表达水平与幽门螺杆菌(helicobacter pylori,Hp)感染的关系。方法 选取2017年12月~2019年12月湖北省孝昌县第一人民医院收治的胃癌患者82例为胃癌组,同期选择该院健康体检者91例为对照组。采用13C呼气试验检测受试者Hp感染情况,采用实时荧光定量PCR法(qPT-PCR)测定受试者血清中miR-181b,PDCD4表达水平,根据光学显微镜下胃癌患者的胃黏膜中Hp感染密度将患者分为Hp感染轻、中、重组,Spearman法分析胃癌患者血清中miR-181b和PDCD4表达水平与Hp感染的相关性。结果 与对照组相比,胃癌组Hp感染阳性率显著增高(χ2=68.571,P<0.05),胃癌组Hp阴性及Hp阳性患者血清中miR-181b表达水平均显著升高(t=13.799,8.158,均P<0.05),PDCD4表达水平均显著降低(t=8.432,19.087,均P<0.05),且胃癌组及对照组Hp阳性患者血清中miR-181b表达水平高于Hp阴性患者(t=3.469,4.163,P<0.05),PDCD4表达水平低于Hp阴性患者(t=8.878,16.470,均P<0.05)。随着胃癌患者Hp感染密度的增加,Hp阳性患者血清中miR-181b表达水平呈依次升高趋势(t=5.476,7.479,2.227,均P<0.05),PDCD4表达水平均呈依次降低趋势(t=10.216,14.014,9.199,均P<0.05),差异有统计学意义。Spearman相关性分析结果显示血清中miR-181b与胃癌患者Hp感染呈正相关性(r=0.659,0.685,均P<0.05),血清中PDCD4与胃癌患者Hp感染呈负相关性(r=-0.611,-0.702,均P<0.05)。结论 胃癌患者血清中miR-181b,PDCD4表达水平与Hp感染密切相关,对于临床Hp感染具有潜在鉴别价值。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(编号:81800586)。
作者简介: 饶向东(1975-),男,本科,副主任医师,主要从事消化内科方面研究工作,E-mail:rxd432900@163.com。
通讯作者:徐龙(1972-),男,博士,E-mail:dlxulong@aliyun.com。
更新日期/Last Update: 2017-12-31