[1]玉丽林,李锦宏,杨静梅,等.鼠双微粒体2 基因 rs1625525 和rs1196336 位点基因多态性与乳腺癌遗传易感性的相关性研究[J].现代检验医学杂志,2023,38(02):52-56.[doi:10.3969/j.issn.1671-7414.2023.02.010 ]
　YU Li-lin,LI Jin-hong,YANG Jing-mei,et al.Association between Murine Double Minute2 Gene rs1625525 and rs1196336 Gene Polymorphisms and Genetic Susceptibility to Breast Cancer[J].Journal of Modern Laboratory Medicine,2023,38(02):52-56.[doi:10.3969/j.issn.1671-7414.2023.02.010 ]
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鼠双微粒体2 基因 rs1625525 和rs1196336 位点基因多态性与乳腺癌遗传易感性的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年02期
页码:
52-56
栏目:
论著
出版日期:
2023-03-15

文章信息/Info

Title:
Association between Murine Double Minute2 Gene rs1625525 and rs1196336 Gene Polymorphisms and Genetic Susceptibility to Breast Cancer
文章编号:
1671-7414（2023）02-052-05
作者:
玉丽林; 李锦宏; 杨静梅; 陈文艳; 刘志昂
（中国人民解放军联勤保障部队第九二三医院检验科，南宁 530020）
Author(s):
YU Li-lin;  LI Jin-hong;  YANG Jing-mei;  CHEN Wen-yan;  LIU Zhi-ang
（Department of Clinical Laboratory, the 923rd Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Nanning 530020, China）
关键词:
鼠双微粒体 2基因; 基因多态性; 乳腺癌; 遗传易感性
分类号:
R737.9；R730.43
DOI:
10.3969/j.issn.1671-7414.2023.02.010
文献标志码:
A
摘要:
目的 探讨鼠双微粒体 2（murine double minute 2，MDM2）基因 rs1625525，rs1196336两个位点多态性与乳腺癌遗传易感性的关系。方法 选取 2021年 1月～12月中国人民解放军联勤保障部队第九二三医院收治的乳腺癌患者 176例，乳腺良性瘤患者 156例，同期女性健康体检者 203例作为研究对象，采用多重 SNaPshot技术检测 MDM2基因 rs1625525A/G和 rs1196336A/T两个位点的基因多态性，比较各组两位点基因型和等位基因频率，分析两个位点多态性与乳腺癌遗传易感性的关系。结果 MDM2基因 rs1625525位点的 AA，AG和 GG基因型在乳腺癌组的基因型频率分别为 48.9%，39.2%和 11.9%，在对照组的基因型频率分别为 50.7%，44.3%和 5.0%。三种基因型在对照组与乳腺癌组分布频率差异有统计学意义（χ2=6.314，P<0.05）, GG基因型和隐性模型可能增加乳腺癌的患病风险 (OR=2.522， 95%CI：1.115～5.708，P=0.026；OR=2.699，95%CI：1.221～5.966，P=0.014）。 rs1196336位点在共显性模型、显性模型、隐性模型和等位基因模型与乳腺癌患病风险均无明显相关性（OR=1.045，95%CI：0.686～1.591；OR=1.048， 95%CI：0.402～2.728； OR=1.045，95%CI：0.694～1.574； OR=1.026，95%CI：0.403～2.613；OR=1.031， 95%CI：0.747～1.423,均 P>0.05）。结论 MDM2基因 rs1625525位点 GG基因型和隐性模型可能增加乳腺癌的患病风险 , rs1196336位点基因多态性与乳腺癌的发病风险无明显相关性。
Abstract:
Objective To investigate the relationshif murine double minute2 (MDM2)gene rs1625525 and rs1196336 and the genetic susceptibility of breast cancer. Methods From January 2021 to December 2021, 176 breast cancer patients, 156 breast benign tumor patients, and 203 female healthy people who were admitted to the 923rd Hospital of the PLA Joint Logistic Support Forcey were selected as the research objects. Multiplex SNaPshot technique was used to detect the gene polymorphism of MDM2 gene rs1625525A/G and rs1196336A/T, the genotypes and allele frequencies of the two loci in each group were compared, and the relationship between polymorphisms of the two loci and genetic susceptibility to breast cancer was analyzed. Results The frequencies of AA, AG and GG genotypes at rs1625525 of MDM2 gene were 48.9%, 39.2% and 11.9% in breast cancer group, and 50.7%, 44.3% and 5.0% in control group, respectively. The three genotypes had statistically significant differences in the distribution frequencies of the control group/breast cancer group (χ2=6.314, P<0.05), and the GG genotype and recessive model may increase the risk of breast cancer (OR=2.522, 95 %CI: 1.115～5.708, P=0.026; OR=2.699, 95%CI: 1.221～5.966, P=0.014). There was no significant correlation between the rs1196336 locus and the risk of breast cancer in the co-dominant model, dominant model, recessive model, and allele model (OR=1.045, 95%CI: 0.686～1.591; OR =1.048, 95%CI: 0.402～2.728; OR=1.045, 95%CI: 0.694～1.574; OR =1.026, 95%CI: 0.403～2.613; OR=1.031, 95%CI: 0.747～1.423, all P>0.05). Conclusion MDM2 gene rs1625525 locus GG genotype and recessive model may increase the risk of breast cancer, and rs1196336 gene polymorphism has no significant correlation with the risk of breast cancer.

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备注/Memo

备注/Memo:
收稿日期：2022-08-29修回日期：2022-11-30
基金项目：广西壮族自治区卫生健康委员会自筹课题（Z20210295）。
作者简介：玉丽林（1987-）女，硕士研究生，主管技师，研究方向：临床检验诊断学， E-mail：531748701@qq.com。
通讯作者：刘志昂（1972-），男，本科，副主任技师， E-mail：gxnnlza@163.com。

更新日期/Last Update: 2023-03-15