[1]乔永峰,胡 健,马燕粉,等.陕西省汉中市1~6 岁儿童血清维生素D 水平调查及影响因素分析[J].现代检验医学杂志,2024,39(04):83-87.[doi:10.3969/j.issn.1671-7414.2024.04.015]
　QIAO Yongfeng,HU Jian,MA Yanfen,et al.Investigation of Serum Vitamin D Levels and Analysis of Related Factors in Children Aged 1 ~ 6 in Hanzhong City of Shaanxi[J].Journal of Modern Laboratory Medicine,2024,39(04):83-87.[doi:10.3969/j.issn.1671-7414.2024.04.015]
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陕西省汉中市1~6 岁儿童血清维生素D 水平调查及影响因素分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年04期
页码:
83-87
栏目:
论著
出版日期:
2024-07-15

文章信息/Info

Title:
Investigation of Serum Vitamin D Levels and Analysis of Related Factors in Children Aged 1 ~ 6 in Hanzhong City of Shaanxi
文章编号:
1671-7414（2024）04-083-05
作者:
乔永峰1; 2; 胡 健1; 马燕粉1; 王晓琴1
（1. 西安交通大学第一附属医院检验科，西安 710061；2. 汉中市中心医院检验科，陕西汉中 723000）
Author(s):
QIAO Yongfeng1; 2; HU Jian1; MA Yanfen1; WANG Xiaoqin1
(1.Department of Clinical Laboratory, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China； 2.Department of Clinical Laboratory, Hanzhong Central Hospital, Shaanxi Hanzhong 723000, China)
关键词:
儿童; 维生素D; 血清25 羟维生素D; 液相色谱串联质谱; 汉中地区
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2024.04.015
文献标志码:
A
摘要:
目的 调查陕西省汉中市儿童血清维生素D 水平及其分布状态，为预防儿童维生素D 缺乏提供依据。方法 选取汉中市中心医院儿童保健门诊2019 年3 月～ 2021 年2 月6 780 例1 ～ 6 岁体检儿童为研究对象，采用液相色谱串联质谱（liquid chromatography-tandem mass spectrometry，LC-MS/MS）法检测血清25 羟基维生素D [25-hydroxyvitamin D，25（OH）D]，25 羟基维生素D2 [25-hydroxyvitamin D2，25(OH)D2] 和25 羟基维生素D3[25-hydroxyvitamin D3，25(OH)D3] 水平，并分析不同年龄、性别、季节间差异。结果 儿童总体血清25(OH)D，25(OH)D2，25(OH)D3水平分别为38.24±9.84 ng/ml，2.31±3.91ng/ml 和35.93±9.93 ng/ml。维生素D 缺乏率为 2.74%（186/6 780），不足率为 18.29%（1 240/6 780），充足率为 78.97%（5 354/6 780）。1 ~ 2 岁、2 ~ 3 岁和3 ~ 6 岁儿童血清25(OH)D 和25(OH)D3 水平随年龄增长而逐渐降低，维生素D 缺乏率增加，差异具有统计学意义（F=1 153.499，1 165.341，1 374.051，均P ＜ 0.05）。不同性别儿童血清25(OH)D，25(OH)D2，25(OH)D3 水平和维生素D 营养分布状态比较，差异均无统计学意义（t/ χ2=0.727，1.271，0.222，2.659，均P ＞ 0.05）。冬季儿童血清25(OH)D 和25(OH)D3 水平均低于春、夏、秋季，差异具有统计学意义（q=6.853，7.281，6.801；5.341，6.225，5.989，均P ＜ 0.01）；维生素D缺乏率高于春、夏、秋季（6.60% vs 2.64%，1.91%，1.66%），差异具有统计学意义（χ2=31.733，52.252，57.756，均P ＜ 0.01）。结论 汉中市3 ~ 6 岁儿童普遍存在维生素D 缺乏或不足，应加强冬季户外活动，鼓励血清维生素D 水平监测，必要时补充维生素D。
Abstract:
Objective To survey the levels and distributed status of serum vitamin D in children in Hanzhong city of Shaanxi, and provide a basis for the prevention of children with vitamin D deficiency. Methods A total of 6 780 children aged 1 to 6 years from March 2019 to February 2021 in Children’s Health Clinic of Hanzhong Center Hospital for physical examination were selected as subjects. The levels of serum 25-hydroxyvitamin D [25(OH)D], serum 25-hydroxyvitamin D2 [25(OH)D2] and serum 25-hydroxyvitamin D3 [25(OH)D3] were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the factors of ages and sexes and seasons were analyzed. Results The levels of serum 25(OH)D，25(OH)D2 and 25(OH)D3 in all children were 38.24±9.84 ng/ml，2.31±3.91 ng/ml and 35.93±9.93 ng/ml, respectively. The vitamin D deficiency rate, insufficiency rate and adequacy rate were 2.75% (186/6 780), 18.29% (1 240/6 780)and 78.96% (5 354/6 780), respectively. The levels of serum 25(OH)D and 25(OH)D3 in children aged 1~2，2~3 and 3~6 years were gradually decreased with the growth of age, while the rate of vitamin D deficiency was increased, with significant differences (F=1 153.499, 1 165.341, 1 374.051, all P<0.05). There were no significant differences in distributed status of serum of vitamin D and the levels of serum 25(OH)D, 25(OH)D2 and 25(OH)D3 levels among different genders (t/ χ2=0.727，1.271，0.222，2.659，all P>0.05). The levels of serum 25(OH)D and 25(OH)D3 in winter were lower than those in spring, summer and autumn, and the differences were statistically significant (q=6.853，7.281，6.801；5.341，6.225，5.989，all P<0.01). The vitamin D deficiency rate in winter was higher than that in spring, summer and autumn (6.60%, 2.64%, 1.91%, 1.66%). and the differences were statistically significant(χ2=31.733, 52.252, 57.756, all P ＜ 0.01)．Conclusion A high incidence of vitamin D deficiency or insufficiency was found in children aged 3 to 6 in Hanzhong city. It was necessary to strengthen outdoor activities in winter, encourage monitoring of serum vitamin D levels, and supplement vitamin D if necessary.

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备注/Memo

备注/Memo:
作者简介：乔永峰（1983-），男，硕士在读，副主任技师，研究方向：临床检验诊断指标研究，E-mail：qiao411081@163.com。
通讯作者：王晓琴，女，主任技师，E-mail：1493722680@qq.com。
更新日期/Last Update: 2024-07-15