[1]王 苗,张 萍.COPD患者血清 Cav-1及 CXCL12水平检测与并发肺动脉高压的相关性研究[J].现代检验医学杂志,2021,36(01):29-32.[doi:10.3969/j.issn.1671-7414.2021.01.008]
 WANG Miao,ZHANG Ping.Correlation between Levels of Cav-1 and CXCL12 in Serum and Pulmonary Hypertension in Patients with COPD[J].Journal of Modern Laboratory Medicine,2021,36(01):29-32.[doi:10.3969/j.issn.1671-7414.2021.01.008]
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COPD患者血清 Cav-1及 CXCL12水平检测与并发肺动脉高压的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
29-32
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Correlation between Levels of Cav-1 and CXCL12 in Serum and Pulmonary Hypertension in Patients with COPD
文章编号:
1671-7414(2021)01-029-05
作者:
王 苗张 萍
(1.咸阳市第一人民医院检验科,陕西咸阳 712000;2.商洛市中心医院医学检验科,陕西商洛 726000)
Author(s):
WANG Miao ZHANG Ping
(1. Department of Clinical Laboratory, the First People’s Hospital of Xianyang City, Shaanxi Xianyang 712000, China; 2.Department of Medical Laboratory,the Central Hospital of Shangluo City,Shaanxi Shangluo 726000,China)
关键词:
慢性阻塞性肺疾病肺动脉高压肺动脉收缩压肺功能检测小窝蛋白 -1趋化因子 C-X-C基元配体 12白介素 -6B型脑利钠肽
分类号:
R563;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.01.008
文献标志码:
A
摘要:
目的 探讨血清小窝蛋白 -1(caveolave-1,Cav-1)及趋化因子 C-X-C基元配体 12(chemokine C-X-C ligand 12,CXCL12)水平与慢性阻塞性肺疾病 (chronic obstructive pulmonary disease,COPD)并发肺动脉高压 (pulmonary hypertension,PH)的相关性。方法 收集 2019年 3月~ 2020年 3月期间在咸阳市第一人民医院和商洛市中心医院就诊的 115例 COPD 患者作为研究对象 ,依据患者是否并发 PH分为非 PH组 (NPH组 ,70例 )和 PH组 (45例 )。另选取 43例同期体检健康者作为对照组,采用酶联免疫吸附法测定血清 Cav-1和 CXCL12水平,所有患者均接受肺功能检测 ,用肺功能检测仪检测患者治疗前的 1s 用力呼气容积占预计值的百分比 (forced expiratory volume/predicted value,FEV1/Pre), FEV1占用力肺活量 (Forced vital capacity,FVC)的百分比 (FEV1/FVC)。通过彩色多普勒超声检查获得所有 COPD患者的肺动脉收缩压 (pulmonary artery systolic pressure,PASP)。收集患者的临床资料 ,包括二氧化碳分压 (PCO2)、氧分压 (PO2)、B型脑利钠肽 (brain natriuretic peptide,BNP)以及白介素 -6(interleukin- 6,IL-6)等,比较分析以上指标的变化与 COPD并发 PH的相关性。结果 在对照组 ,NPH组和 PH组中 ,血清 Cav-1和 CXCL12水平分别为 10.37±2.28,7.23±1 .72,4.81±0.90μg/L和 65.74±12.27, 175.36±26.19, 270.33±43.79pg/ml,与对照组比较 ,NPH组和 PH组的 CXCL12水平明显增高 ,且 PH组增高更显著 ;与对照组比较 ,NPH组和 PH组的 Cav-1水平则明显降低 ,且 PH组降低更显著,差异均有统计学意义 (F=103.71~ 130.67,均 P=0.000)。相关性分析显示 ,NPH组和 PH组的血清 Cav-1及 CXCL12水平分别呈负相关性 (r=-0.813,-0.827, 均 P <0.01),NPH组的 CXCL12水平分别与 PCO2,PASP,IL-6及 BNP水平呈正相关性 ,而与 FEV1/Pre,FEV1/FVC及 PO2呈负相关性。 NPH组的 Cav-1分别与 PCO2,PASP,IL-6及 BNP水平呈负相关性 ,而与 FEV1/Pre,FEV1/FVC及 PO2呈正相关性( rCXCL12=0.845,0.810,0.807,0.783,-0.799,-0.775和 -0.793,均 P<0.01;rCav-1=-0.853,-0.828,-0.816,-0.792,0.763,0.803,0.822,均 P <0.01)。PH组的 CXCL12水平分别与 PCO2,PASP,IL-6及 BNP水平呈正相关性 ,而与 FEV1/Pre,FEV1/FVC及 PO2呈负相关性。 PH组的 Cav-1水平分别与 PCO2,PASP,IL-6及 BNP水平呈负相关性,而与 FEV1/Pre,FEV1/FVC及 PO2呈正相关性( rCXCL12=0.839,0.816, 0.817,0.806,-0.782,-0.785,-0.809,均 P<0.01;rCav-1=-0.862,-0.821,-0.819,-0.797,0.782,0.811,0.829,均 P <0.01)。结论 血清 Cav-1及 CXCL12水平的差异性变化可能与 COPD患者 PH的形成有关,调节 Cav-1及 CXCL12水平能抑制炎症因子释放 ,缓解 COPD病情进展 ,改善患者的临床症状。

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备注/Memo

备注/Memo:
作者简介:王苗(1980-),女,大学本科,主管检验师,研究方向:肺部疾病的实验室诊断, E-mail:1533840062@qq.com。通讯作者:张萍(1987-),女,大学本科,主管检验师,研究方向:肺部疾病的实验室诊断,E-mail:2634085934@qq.com。
更新日期/Last Update: 2021-02-05