[1]何家花,汪 阔,余成强.血流感染产超广谱 β-内酰胺酶大肠埃希菌的药敏结果及感染危险因素分析[J].现代检验医学杂志,2021,36(01):128-131.[doi:10.3969/j.issn.1671-7414.2021.01.032]
 HE Jia-hua,WANG Kuo,YU Cheng-qiang.Drug Sensitivity and Risk Factors Analysis of Escherichia Coli Producing Extended-spectrum β-lactamases by Bloodstream Infection[J].Journal of Modern Laboratory Medicine,2021,36(01):128-131.[doi:10.3969/j.issn.1671-7414.2021.01.032]
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血流感染产超广谱 β-内酰胺酶大肠埃希菌的药敏结果及感染危险因素分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
128-131
栏目:
检验与临床
出版日期:
2021-02-05

文章信息/Info

Title:
Drug Sensitivity and Risk Factors Analysis of Escherichia Coli Producing Extended-spectrum β-lactamases by Bloodstream Infection
文章编号:
1671-7414(2021)01-128-04
作者:
何家花汪 阔余成强
(商洛市中心医院医学检验科,陕西商洛 726000)
Author(s):
HE Jia-hua WANG KuoYU Cheng-qiang
(Department of Medical Laboratory, Shangluo Central Hospital, Shaanxi Shangluo 726000,China)
关键词:
血流感染超广谱 β -内酰胺酶大肠埃希菌危险因素
分类号:
R378.21;R446.5
DOI:
10.3969/j.issn.1671-7414.2021.01.032
文献标志码:
A
摘要:
目的 分析血流感染产超广谱 β -内酰胺酶( ESBLs)大肠埃希菌的药敏特点和危险因素,为临床诊疗和预防提供依据。方法 回顾性分析商洛市中心医院 111例大肠埃希菌血流感染的药敏结果和临床特点,根据大肠埃希菌是否产 ESBLs分为 ESBLs组和非 ESBLs组,分析两组药敏结果差异,并探讨产 ESBLs大肠埃希菌血流感染的危险因素。结果 111株大肠埃希菌中, 81株产 ESBLs ,占 73.0%。对 21种常用抗生素进行药敏实验, ESBLs组的耐药率明显高于非 ESBLs 组,敏感率低于非 ESBLs组。ESBLs组对氨苄西林、头孢唑林、头孢曲松、头孢哌酮和头孢噻肟的耐药率超过 85%,两组对阿米卡星、亚胺培南、美罗培南和哌拉西林 /他唑巴坦的敏感率均超过 90%。两组间比较阿莫西林 /克拉维酸、四环素、哌拉西林 /他唑巴坦、亚胺培南、美罗培南和阿米卡星六种药物的耐药率和敏感率差异均无统计学意义 (χ2= 0.000~3.700,均 P>0.5)。单因素分析显示各种置管、β -内酰胺类或酶抑制剂复合制剂使用、并发高血压三个因素在两组间差异有统计学意义 (χ2= 8.066,P= 0.005;χ2= 8.828,P= 0.003;χ2= 4.022,P= 0.045)。多因素分析显示 β -内酰胺类或酶抑制剂复合制剂使用、各种置管是产 ESBLs大肠埃希菌血流感染的独立危险因素 (χ2= 6.703, P= 0.001;χ2= 4.511,P= 0.034)。结论 该院血流感染大肠埃希菌 ESBLs检出率和耐药率较高。患者使用 β -内酰胺类或酶抑制剂复合制剂治疗和各种置管时需警惕血流感染产 ESBLs大肠埃希菌的发生。

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备注/Memo

备注/Memo:
作者简介:何家花(1987-),女,本科,在职硕士,主管检验师,从事临床微生物与分子生物学检测工作, E-mail:745249229@qq.com。
通讯作者:汪阔,主管检验师,E-mail:wagkuo@126.com。
更新日期/Last Update: 2021-02-05