[1]卫 娜,杨小丽,尚 亮.盐水负荷试验盐敏感者的大动脉弹性变化及其与C反应蛋白和单核细胞趋化蛋白1的相关性研究[J].现代检验医学杂志,2016,31(02):49-52.[doi:10.3969/j.issn.1671-7414.2016.02.015]
　WEI Na,YANG Xiao-li,SHANG Liang.Relation between C-reaction Protein,Monocyte Chemoattractant Protein1 and the Change of Arterial Elasticity in Salt Sensitivity Patients[J].Journal of Modern Laboratory Medicine,2016,31(02):49-52.[doi:10.3969/j.issn.1671-7414.2016.02.015]
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盐水负荷试验盐敏感者的大动脉弹性变化及其与C反应蛋白和单核细胞趋化蛋白1的相关性研究()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
49-52
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Relation between C-reaction Protein,Monocyte Chemoattractant Protein1 and the Change of Arterial Elasticity in Salt Sensitivity Patients
作者:
卫 娜,杨小丽,尚 亮
陕西省人民医院西院二病区,西安 710068
Author(s):
WEI Na,YANG Xiao-li,SHANG Liang
Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
盐敏感性;  大动脉弹性;  C反应蛋白;  单核细胞趋化蛋白-1
分类号:
R392.1
DOI:
10.3969/j.issn.1671-7414.2016.02.015
文献标志码:
A
摘要:
目的 观察人群中盐敏感者的大动脉弹性变化及其与C反应蛋白、单核细胞趋化蛋白1的相关性。方法 选择原发性高血压患者64例以及正常对照组60例,通过口服盐水负荷试验及速尿缩容法将人群分别分为盐敏感者(SS)以及盐不敏感者(SR)。通过检测脉压指数、脉压、肱踝脉搏波传导速度(baPWV)作为大动脉弹性指标,使用ELISA法测定各组血清C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1),并观察其与大动脉弹性指标之间的相关性。结果 对照组中盐敏感者的脉压,baPWV明显高于盐不敏感者(61±18 vs 53±9 mmHg,t=7.71,P<0.05; 13.1±1.9 vs 11.9±2.8 m/s,t=3.65,P<0.05); 高血压组盐敏感者的脉压,baPWV亦高于盐不敏感者(71±15 vs 63±17 mmHg,t=13.86,P<0.05; 15.7±2.1 vs 14.3±1.8 m/s,t=4.04,P<0.05),差异均有统计学意义。对照组中盐敏感者的CRP,MCP-1水平高于盐不敏感者(6.89±2.75 vs 5.24±1.55 mg/L,t=22.02,P<0.05; 155.32±20.66 vs 100.11±10.75 pg/ml,t=75.97,P<0.05); 高血压组中盐敏感者的CRP,MCP-1水平亦高于盐不敏感者(8.28±3.61 vs 7.02±2.53 mg/L,t=21.86,P<0.05; 260.42±35.59 vs 200.18±45.17 pg/ml,t=63.72,P<0.05),差异均有统计学意义。CRP,MCP-1与脉压(r=0.451,0.374,P<0.05),baPWV(r=0.390,0.237,P<0.05)呈正相关性。结论 与盐不敏感者比较,盐敏感者的大动脉弹性降低,炎症反应可能参与了其大动脉弹性降低的过程。
Abstract:
Objective To investigate the change of arterialelasticity in salt sensitivity patients and relation between inflammatory factors level.Methods 60 healthy people and 64 mild to moderate hypertensive patients were recruited in this study.According to acute oral saline loading and furosemide volume-depletion tests,patients were divided intosalt-sensitive group(SS)and non-salt-sensitive group(SR).The serum C-reaction protein(CRP)and monocyte chemoattractant protein1(MCP-1)were measured by ELISA assay.Arterial elasticity was reflected by detecting pulse pressure(PP),pulse pressure index(PPI),ankle arteries-brachial artery pulse wave velocity(baPWV),and its relationship to CRP and MCP-1 were observed.Results In the coutrol group,pulse pressure(PP),ankle arteries-brachial artery pulse wave velocity(baPWV)were increased in SS group(61±18 vs53±9 mmHg,t=7.71,P<0.05; 13.1±1.9 vs 11.9±2.8 m/s,t=3.65,P<0.05),In the hypertension group,the PP and baPWV were increased in SS group(71±15 vs 63±17 mmHg,t=13.86,P<0.05; 15.7±2.1 vs 14.3±1.8 m/s,t=4.04,P<0.05).In the coutrol group,the CRP,MCP-1 were increased in SS group(6.89±2.75 vs 5.24±1.55 mg/L,t=22.02,P<0.05; 155.32±20.66 vs 100.11±10.75 pg/ml,t=75.97,P<0.05),In the hypertension group,the CRP and MCP-1 were increased in SS group(8.28±3.61 vs 7.02±2.53 mg/L,t=21.86,P<0.05; 260.42±35.59 vs 200.18±45.17 pg/ml,t=63.72,P<0.05).The serum CRP and MCP-1 were positively correlated with PP(r=0.451,0.374,P<0.05)and baPWV(r=0.390,0.237,P<0.05).Conclusion The arterial elasticity of SS was decreased compared with the SR,the increase of inflammatory factors may promote the arterial elasticity.

参考文献/References:

[1] Choi HY,Park HC,Ha SK.Salt sensitivity and hypertension:a paradigm shift from kidney malfunction to vascular endothelial dysfunction[J].Electrolvte Blood Press,2015,13(1):7-16.
[2] Van Bussel BC,Schouten F,Henry RM,et al.Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period[J].Hypertension,2011,58(4):588-95.
[3] Weinberger MH,Fineberg NS,Fineberg SE,et al.Salt sensitivity,pulse pressure,and death in normal and hypertensive humans[J].Hypertension,2001,37[part2]:429-432.
[4] Zhao L,Song Y,Donq P,et al.Brachial pulse pressure and cardiovascularor all-cause mortality in the general population:a meta-analysis of prospective observational studies[J].J Clin Hypertens,2014,16(9):678-85.
[5] White WB.The systolic blood pressure versus pulse pressure controversy[J].Am J Cardiol,2001,87(11):1278-1281.
[6] Rocha E. Pulse wave velocity:a marker of arterial stiffness and its applicability in clinical practice[J].Rev Port Cardiol,2011,30(9):699-702.
[7] 宋立彪,宋 瑛,裴 峰,等.血清高敏C反应蛋白水平对2型糖尿病患者并发动脉粥样硬化的监测意义[J].现代检验医学杂志,2013,28(5):126-128,131. Song LB,Song Y,Pei F,et al.Monitor signification of high sensitive C-reactive protein level in patient with type 2 diabetes complicated with atherosclerosis[J].Journal of Modern Laboratory Medicine,2013,28(5):126-128,131.
[8] Sardo MA,Campo S,Mandraffion G,et al.Tissue factor and monocyte chemoattractant protein1 expression in hypertensive individuals with normal or increased carotid intima-media wall thickness[J].Clin Chem,2008,54(5):814-823.
[9] 王舒健,路方红,赵振东,等.正常高值血压者单核细胞趋化因子1与动脉僵硬度的相关性[J].中华高血压杂志,2011,19(7):663-667. Wang SJ,Lu FH,Zhao ZD,et al.Relationship between monocyte chemoattractant protein1 and arterial stiffness in prehypertensives[J].Chinese Journal of Hypertension,2011,19(7):663-667.

备注/Memo

备注/Memo:
基金项目:陕西省科学技术研究发展计划项目(2012K15-01-04)。 作者简介:卫 娜(1982-),女,硕士,主治医师,主要从事老年医学工作,Tel:18992859729,E-mail:weina20071@126.com。
更新日期/Last Update: 2016-02-20