[1]吴玉双,王学涵,夏俊娣.慢性阻塞性肺疾病患者血清IL-6和黏着斑激酶水平检测临床意义[J].现代检验医学杂志,2016,31(02):115-116,119.[doi:10.3969/j.issn.1671-7414.2016.02.034]
 WU Yu-shuang,WANG Xue-han,XIA Jun-di.Significance of the Detecting IL-6 and FAK in Chronic Obstructive Pulmonary Disease[J].Journal of Modern Laboratory Medicine,2016,31(02):115-116,119.[doi:10.3969/j.issn.1671-7414.2016.02.034]
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慢性阻塞性肺疾病患者血清IL-6和黏着斑激酶水平检测临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
115-116,119
栏目:
检验与临床
出版日期:
2016-06-01

文章信息/Info

Title:
Significance of the Detecting IL-6 and FAK in Chronic Obstructive Pulmonary Disease
作者:
吴玉双1王学涵2夏俊娣1
1.天津市职工医院内科,天津 300050; 2.新疆医科大学第五附属医院检验科,乌鲁木齐 830011
Author(s):
WU Yu-shuang1WANG Xue-han2XIA Jun-di1
1.Department of Medicine,Worker's Hospital of Tianjing,Tianjing 300050,China; 2.Department of Clinical Laboratory, the Fifth Affiliated Hospital of Xinjiang Medical University,Urumchi 830011,China
关键词:
黏着斑激酶(FAK) 白细胞介素-6 慢性阻塞性肺疾病
分类号:
R563; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.02.034
文献标志码:
A
摘要:
目的 探讨慢性阻塞性肺疾病(COPD)患者检测血清IL-6和粘着斑激酶(FAK)水平的意义。方法 选取COPD患者120例,对照组100例健康人群,通过酶联免疫吸附法(ELISA)检测血清IL-6和FAK水平。结果对照组和COPD各分级组间血尿酸、胆固醇和三酰甘油差异均无统计学意义(F=0.891~1.254,均P>0.05),而FAK和IL-6水平比较差异有统计学意义(F=10.451~25.387,均P<0.05)。COPDⅠ~Ⅳ级IL-6水平有升高的趋势,但各分级组间IL-6水平差异无统计学意义(t=0.098~0.145,均P>0.05)。COPDⅠ~Ⅳ级FAK水平差异有统计学意义(t=33.541~55.612,均P<0.05)。IL-6和FAK存在显著的正相关(r=0.881)。结论 检测血清FAK可反映COPD患者严重程度,且它是呼吸道平滑肌细胞增殖的靶标。
Abstract:
Objective To discuss on the significance of detection IL-6 and FAK in chronic obstructive pulmonary disease(COPD).Methods Chosed 120 patients with suspected COPD and 100 cases as control group and detected IL-6 and FAK level by ELISA method.ResultsThere were no statistical difference among UA,TC and TG level between COPD and control group(F=0.891~1.254,P>0.05).However IL-6 and FAK level had statistical difference between COPD and control group(F=10.451~25.387,P<0.05).There was a increased tendency of IL-6 level fromⅠ phaseto Ⅳ phase,but no statistical difference(t=0.098~0.145,P>0.05).There was statistical difference of FAK level fromⅠphase to Ⅳ phase(t=33.541~55.612,P<0.05).IL-6 level was positively related to FAK level(r=-0.881).Conclusion FAK level in serum was detected in orderto diagnose the serious degree of COPD.It can be a new indicator for smooth muscle cell proliferation of respiratory tract.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:吴玉双(1975-),女,医学硕士,主治医师,主要从事临床呼吸疾病的诊疗工作。 通讯作者:夏俊娣,主任医师,E-mail:XJD@126.com。
更新日期/Last Update: 2016-02-20