[1]热孜万古力·阿帕尔,吴 红.2型糖尿病肾病患者检测血清基质金属蛋白酶-10的意义[J].现代检验医学杂志,2016,31(03):111-113.[doi:10.3969/j.issn.1671-7414.2016.03.031]
　RIZWANGUL·Apaer,WU Hong.Study on the Significance of Detecting MMP-10 Level in Patients with Type 2 Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(03):111-113.[doi:10.3969/j.issn.1671-7414.2016.03.031]
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2型糖尿病肾病患者检测血清基质金属蛋白酶-10的意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
111-113
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Study on the Significance of Detecting MMP-10 Level in Patients with Type 2 Diabetic Nephropathy
文章编号:
1671-7414(2016)03-111-03
作者:
热孜万古力·阿帕尔1; 吴 红2
1.新疆喀什地区第一人民医院肾病科,新疆喀什 844000;
2.新疆生产建设兵团第二师库尔勒医院检验科,新疆库尔勒 841000
Author(s):
RIZWANGUL·Apaer1; WU Hong2
1.Nephropathy Department,the First People's Hospital of Xinjiang Kashi District,Xinjiang Kashi 844000,China;
2.Department ofClinical Laboratory,Korla Hospital,the Second Division of Production and Construction Corps,Xinjiang Korla 841000,China
关键词:
基质金属蛋白酶10(MMP-10);  糖尿病肾病;  肾功能
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.03.031
文献标志码:
A
摘要:
目的 探讨血清基质金属蛋白酶-10(MMP-10)水平与2型糖尿病肾病发病的关系。方法 将100例2型糖尿病肾病患者按糖尿病肾病(DN)诊断标准分为糖尿病无肾病(DM)组(42例)与DN组(58例)。按照Mogenson分期将DN组分为DN早期(DN1)30例,DN晚期(DN2)28例。另择60例健康体检者作为正常对照(NC)组。同时检测糖化血红蛋白(HbA1c)、肌酐(Scr)、尿素氮(BUN)、24 h尿微量清蛋白排泄率(UAER)、β2微球蛋白(β2-MG)和MMP-10,进行相关的统计学分析。结果 DM,DN和NC组HbA1c,Scr,UAER,BUN,β2-MG和MMP-10指标差异有统计学意义(F=6.478～10.892,均P<0.05)。DM组和NC组间除HbA1c外其它检测指标差异均无统计学意义(t=1.421～2.637,均P>0.05),而DN组与NC组比较差异均有统计学意义(t=8.451～26.678,均P<0.05)。DN组和DM组间除HbA1c外其它检测指标差异均有统计学意义(t=6.371～21.673,均P<0.05)。DN1组和DN2组间HbA1c,Scr,UAER,BUN和β2-MG差异无统计学意义(t=0.891～1.385,均P>0.05)。而DN2组MMP-10水平明显比DN1组高,两组差异有统计学意义(t=86.371,P<0.01)。结论 血清MMP-10水平可能是2型糖尿病肾病患者肾脏损伤程度的靶标。
Abstract:
Objective To explore the significance of detecting serum MMP-10 in type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups,that wasDM(42 cases)and DN(58 cases)group,and 60 casescontrolgroup(NC).By Mogenson,DN1(30 cases)and DN2(28 cases),HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 leves were detected by the standard method.Results There were obvious differences of HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 levels among DN,DM and NC(P<0.05).Apart of HbA1c,others were no differences between DM group and NC group(P>0.05).DN group was higher significantly than these in DM group(P<0.05),and HbA1c,BUN,Scr,UAER,and β2-MG levels hadno statistical difference between DN1 and DN2 group.MMP-10 level in DN2 was higher thanthat in DN1 group(P<0.05).Conclusion MMP-10 in serum may be a role indicator for impairment of renal function for diagnosis of type 2 diabetic nephropathy.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:热孜万古力·阿帕尔(1978-),女,维族,主治医师,主要从事临床肾病诊断和治疗工作。
更新日期/Last Update: 2016-06-25