[1]范艳平a,易甲其a,吴 敏b.缺血性脑卒中患者血清Hcy和EPO水平的变化及其与颈动脉粥样硬化关系[J].现代检验医学杂志,2017,32(01):80-83.[doi:10.3969/j.issn.1671-7414.2017.01.022]
　FAN Yan-pinga,YI Jia-qia,WU Minb.Changes of Serum Hcy and EPO Levels in Patients with Ischemic Stroke and Their Relationship with Carotid Artery Atherosclerosis[J].Journal of Modern Laboratory Medicine,2017,32(01):80-83.[doi:10.3969/j.issn.1671-7414.2017.01.022]
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缺血性脑卒中患者血清Hcy和EPO水平的变化及其与颈动脉粥样硬化关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
80-83
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
Changes of Serum Hcy and EPO Levels in Patients with Ischemic Stroke and Their Relationship with Carotid Artery Atherosclerosis
文章编号:
1671-7414(2017)01-080-04
作者:
范艳平a; 易甲其a; 吴 敏b
深圳市龙华新区人民医院 a.景龙社区健康服务中心;
b.三联社区健康服务中心,深圳 518109
Author(s):
FAN Yan-pinga; YI Jia-qia; WU Minb
a.Jinglong Community Health Service Center;
b.Sanlian Community Health Service Center, Shenzhen Longhua New District People's Hospital,Guangdong Shenzhen 518109,China
关键词:
同型半胱氨酸;  促红细胞生成素;  颈动脉粥样硬化
分类号:
R743.3; R446.11
DOI:
10.3969/j.issn.1671-7414.2017.01.022
文献标志码:
A
摘要:
目的 分析缺血性脑卒中患者血清中同型半胱氨酸(Hcy)和促红细胞生成素(EPO)的水平变化及其与颈动脉粥样硬化之间的关系。方法 选择某医院神经内科2013年1月1日～2016年7月31日之间收治的缺血性脑卒中患者作为研究对象,通过血清学检验Hcy,EPO水平,再通过多普勒探查颈动脉的方法,检查所有患者的颈动脉粥样硬化程度,并利用量化的方式记录下来,按照设定的诊断标准进行分级,利用分级结果与Hcy,EPO水平进行数据分析,判定两者之间的关系。结果 142例患者的多普勒探查结果显示,34例患者的颈动脉内中膜厚度正常,56例患者的颈动脉内中膜增厚,52例患者被判定到颈动脉斑块组,经过方差分析检验,Hcy,EPO两个项目在三个组别中差异均有统计学意义(F=59.64,78.29,P＜0.05),经过q检验,任意两组之间的数据也同样出现统计学差异。对108例不同级别的颈动脉粥样硬化患者进行了分级,其中属于1级的47例,属于2级的34例,属于3级的27例,在不同级别患者血浆Hcy,EPO水平之间的对比,通过方差分析检验,差异均有统计学意义(F=78.39,48.61,P＜0.05),经过q检验,任意两组之间的数据也同样出现统计学差异。结论人体血清中的Hcy和EPO与缺血性脑卒中有一定的相关性,并且同颈动脉粥样硬化的级别也有相关性。
Abstract:
Objective To analysis the levels of serum homocysteine(Hcy)and erythropoietin(EPO)levels in patients with ischemic stroke and their relationship with carotid atherosclerosis.Methods The patients with ischemic stroke admitted between January 1,2013 and July 31,2016 were selected as the subjects.Sera test of Hcy,EPO level,and then through the Doppler probe carotid artery method to check the degree of carotid atherosclerosis in all patients,and the use of quantitative records,according to set diagnostic criteria for classification,the use of grading results with the same type of Hcy,EPO levels of dataanalysis to determine the relationship between the two.Results Doppler exploration in 142 patients showed normal carotid intima-mediathickness in 34 patients,carotid intima-media thickening in 56 patients,and carotid plaques in 52 patients.After analysis of variance(F=59.64,78.29,P＜0.05),and the difference between the two groups was statistically significant(P＜0.05),and the difference between the two groups was statistically significant.The data between any two groups were also statistically significant differences.108 patients with different levels of carotid atherosclerosis were graded into 47 of grade 1,34 of grade 2,and 27 of grade 3,with the same type in the plasma of different grades(F=78.39,48.61,P＜0.05).After the qtest,there were no significant differences in the levels of Hcy and EPO.Data werealso statistically different between groups.Conclusion Serum homocysteine(Hcy)and erythropoietin(EPO)were associated with ischemic stroke and were associated with carotid atherosclerosis.

参考文献/References:

[1] 田 怡,欧阳松,王家祺,等.Hcy,hs-CRP与急性脑梗死患者颈动脉粥样硬化关系的研究[J].现代生物医学进展,2016,16(20):3853-3857. Tian Y,Ouyang S,Wang JQ,et al.Reseach on the correlation of Hcy,hs-CRP and carotid artery atherosclerosis in patients with acute cerebral infarction[J].Progress in Modern Biomedical,2016,16(20):3853-3857.
[2] 陈 亮,史晓洁,刘志忠,等.外周血指标对急性出血性脑卒中深静脉血栓的诊断价值研究[J].检验医学与临床,2016,13(20):2861-2863. Chen L,Shi XJ,Liu ZZ,et al.Diagnostic value of Peripheral bloodindexes for deep venous thrombosis after acute hemorrhagic stroke[J].Lab MedClin,2016,13(20):2861-2863.
[3] 邓 涛,王长翠,谢明水,等.急性心肌梗死患者联合检测IMA和Hcy的临床意义[J].中国实验诊断学,2016,20(10):1727-1728. Deng T,Wang CC,Xie MS,et al.In patients with acute myocardial infarction combined detection of IMA and clinical significance of Hcy[J].Chin JLab Diagno,2016,20(10):1727-1728.
[4] 胡 青,布娃加·吾守尔,梅彩霞.高血压患者臂踝脉搏波传导速度、颈动脉内膜中膜厚度与同型半胱氨酸、D-二聚体的相关性[J].中国动脉硬化杂志,2016,24(10):1019-1022. Hu Q,Buwajia WSR.Mei CX.Patients with high blood pressure arm ankle pulse wave conduction velocity,film thickness in the carotid artery intima and homocysteine,D-dimer correlation[J].Chinese Journal of Arteriosclerosis,2016,24(10):1019-1022.
[5] 徐东升,黄 伟,胡玲玲,等.脑出血患者血液标志物的变化及临床意义[J].海南医学,2016,27(19):3118-3120. Xu DS,Huang W,Hu LL,et al.Changes of blood markers in patients with cerebral hemorrhage and its clinical significance[J].Hainan Medical Journal,2016,27(19):3118-3120.
[6] 肖学文.NT-proBNP和Hcy检测在老年急性脑梗死患者中的临床意义[J].河北医学,2016,22(9):1423-1425. Xiao XW.The clinical significance of NT-proBNP and Hcy in elderlypatients with acute cerebral infarction[J].Hebei Medicine,2016,22(9):1423-1425.
[7] 张新春.探讨急性心肌梗死早期诊断联合检测H-FABP和Hcy的临床价值[J].中国卫生检验杂志,2016,26(18):2652-2655. Zhang XC.Exploration on the clinical significance of the early diagnosis of acute myocardial infarction combined with the detection ofH - FABP and the Hcy[J].Chinese Journal of Health Inspection,2016,26(18):2652-2655.
[8] 施瑞洁,刘文康,李 博,等.血浆D-D,FDP及血清hs-CRP检测对多发性腔隙性脑梗死的临床意义[J].现代检验医学杂志,2015,30(6):75-77. Shi RJ,Liu WK,Li B,et al.Clinical study on plasma D-D,FDP andsera hs-CRP test for multipleh lacunar infarction[J].Journal of Modern Laboratory Medicine,2015,30(6):75-77.
[9] 刘 哲,王 晶.急性脑梗死患者血浆氧化剂低密度脂蛋白浓度与动脉斑块的关系[J].心血管康复医学杂志,2016,25(5):477-480. Liu Z,Wang J.Relationship between plasma OX-LDL concentration and atherosclerotic plaques in patients with acute cerebral infarction[J].Chinese Journal of Cardiovascular Rehabilitation Medical,2016,25(5):477-480.
[10] 何 明,何继荣,宋永建.血清同型半胱氨酸、纤维蛋白原与急性缺血性脑卒中预后的相关性研究[J].海南医学,2016,27(19):3124-3126. He M,He JR,Song YJ.Relationship of prognosis with homocysteine and fibrinogen acute ischemic stroke[J].Hainan Medical Journal,2016,27(19):3124-3126.
[11] 胡华兵,胡正清,徐 广,等.血清C-反应蛋白及同型半胱氨酸水平与冠心病PCI预后的相关性研究[J].临床心血管病杂志,2016,32(9):914-917. Hu HB,Hu ZQ,Xu G,et al.C-reactive protein and serum homocysteine level and prognosis of coronary heart disease(CHD)PCI correlation study[J].Journal of Clinical Cardiovascular Disease,2016,32(9):914-917.
[12] 曹春辉,黄 军,陈小亮,等.内源性硫化氢和同型半胱氨酸与高血压合并主动脉夹层的相关研究[J].中国循证心血管医学杂志,2016,8(9):1072-1074. Cao CH,Huang J,Chen XL,et al.Correlation between endogenous hydrogen sulfide or homocysteine and hypertension combined aortic dissection[J].Chinese Journal of Evidence-Based Cardiovascular Medicine,2016,8(9):1072-1074.
[13] 陈海恋,何超明,庞明武,等.高龄急性脑梗死患者同型半胱氨酸与颈动脉硬化的相关性[J].中国热带医学,2016,16(9):930-933. Chen HL,He CM,Pang MW,et al.Correlation of homocysteine with carotidatherosclerosis in elderly patients with acute cerebral infarction and the correlation[J].China Tropical Medicine,2016,16(9):930-933.
[14] 徐冬新,傅 颖.冠状动脉粥样硬化性心脏病患者血清总胆汁酸、超敏C反应蛋白、同型半胱氨酸、血脂水平变化的相关性研究[J].中国卫生检验杂志,2016,26(17):2503-2507. Xu DX,Fu Y.Coronary atherosclerotic heart disease patients serum total bile acid, hypersensitive C-reactive protein,with half a glycine,blood lipidlevel of correlation study[J].Chinese Journal of Health Inspection,2016,26(17):2503-2507.
[15] 孙树敏,张力辉,罗晓晨,等.临床生化指标与急性脑梗死病情的相关性分析[J].解放军预防医学杂志,2016,34(4):256-260. Sun SM,Zhang LH,Luo XC,et al.Clinical biochemical indicators and the relativity analysis of acute brain infarction disease[J].Journal of PLA Preventive Medical Journal,2016,34(4):256-260.
[16] 马亚峰,冯海翔.急性脑出血患者初次血糖、糖化血红蛋白A1c及血氨水平联合测定的临床分析[J].现代检验医学杂志,2007,22(4):75-76. Ma YF,Feng HX.First blood sugar,glycosylated hemoglobin A1c in patientswith acute cerebral hemorrhage and the combined determination of blood ammonialevel clinical analysis[J].J Mod Lab Med,2007,22(4):75-76.
[17] 宁晓霞.缺血性脑卒中患者凝血因子Ⅰ浓度与血小板平均体积的动态变化[J].现代检验医学杂志,2007,22(4):97-98. Ning XX.Ischemic cerebral apoplexy patients blood coagulation factor I concentration and the dynamic changes of the average platelet volume[J].J Mod Lab Med,2007,22(4):97-98.

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备注/Memo

备注/Memo:
作者简介:范艳平(1982-),男,本科,主管检验师,研究方向:临床检验,Tel:13927417704。
更新日期/Last Update: 2017-01-20