[1]赵 耕.2型糖尿病患者血清网膜素-1水平与肾损伤程度关系的研究[J].现代检验医学杂志,2018,33(01):115-117.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　ZHAO Geng.Study on the Relationship between Serum Omentin-1 Level and Degree of Kidney Injuryin Patient with Type 2 Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2018,33(01):115-117.[doi:10.3969/j.issn.1671-7414.2018.01.001]
点击复制

2型糖尿病患者血清网膜素-1水平与肾损伤程度关系的研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
115-117
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Study on the Relationship between Serum Omentin-1 Level and Degree of Kidney Injuryin Patient with Type 2 Diabetic Nephropathy
文章编号:
1671-7414(2018)01-115-03
作者:
赵 耕
天津医科大学代谢病医院检验科,天津 300070
Author(s):
ZHAO Geng
Department of Clinical Laboratory, Metabolic Disease Hospital Affiliated Tianjin Medical University,Tianjin300070,China
关键词:
血清网膜素-1;  糖尿病肾病;  胰岛素抵抗
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨血清网膜素-1(serum omentin-1)水平与2型糖尿病(T2DM)肾病发病的关系。方法 将100例2型糖尿病肾病患者按糖尿病肾病(diabetic nephropathy,DN)诊断标准分为DM组(44例)与DN组(56例)。按照Mogenson分期将DN组分为DN早期(DN1)30例,DN晚期(DN2)26例。另择80例健康体检者作为正常对照组(NC)。同时检测糖化血红蛋白(HbA1c)、肌酐(Scr)、尿素氮(BUN)、β2微球蛋白(β2-MG)、胰岛素抵抗指数(HOMA-IR)和血清网膜素-1,进行相关的统计学分析。结果DM,DN和NC组HbA1c,Scr,BUN,β2-MG,HOMA-IR和血清网膜素-1指标差异均有统计学意义(F=6.078～16.231,均P<0.05)。其中DM组和NC组间除了HbA1c和HOMA-IR以外,其它检测指标相比差异均无统计学意义(t=1.421～2.637,均P>0.05),而DN组与NC组上述六项指标相比差异均有统计学意义(t=8.981～26.785,均P<0.05)。DN组和DM组间检测指标差异均有统计学意义(t=6.371～21.673,均P<0.05)。DN1组和DN2组间HbA1c,Scr,BUN和β2-MG差异均无统计学意义(t=0.981～1.389,均P>0.05)。而DN2组HOMA-IR水平明显比DN1组高,而血清网膜素-1水平明显比DN1组低,两组差异均有统计学意义(t=68.451～76.814,均P<0.01)。DN组HOMA-IR水平与血清网膜素-1指标呈显著负相关(r=-0.405,P<0.05)。结论 血清网膜素-1与胰岛素抵抗关系密切,血清网膜素-1可能是2型糖尿病患者肾脏损伤程度的靶标。
Abstract:
Abstract:Objective To explore the relationship between serum Omentin-1 level and degree of kidney in juryin patient with type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups:DM(44 cases)and DN(56 cases)group,andby Mogenson,DN group were devided into DN1(30 cases)and DN2(26 cases).In addition 80 healthy subjects were selected as control group.HbA1c,BUN,Scr,β2-MG,HOMA-IR and serum Omentin-1 leves were detected by thestandard method.Results There were obvious differences of HbA1c,BUN,Scr,β2-MG,HOMA-IR and Serum Omentin-1 levels among DN,DM and NC(F=6.078～16.231,all P<0.05).Apart of HbA1c and HOMA-IR,others were no differences between DM group and NC group(t=1.421～2.637,allP>0.05).There were significant differences of these indicators between DNand NC group(t=8.981～26.785,all P<0.05).DN group was higher significantly than these in DM group(t=6.371～21.673,all P<0.05),and HbA1c,BUN,Scr and β2-MG levels had no statistical difference between DN1 andDN2 group(t=0.981～1.389,all P>0.05).HOMA-IR level in DN2 was higher than that in DN1 group,and serum Omentin-1 declined(t=68.451～76.814,all P<0.01).There were negative correlation between HOMA-IR and serum Omentin-1 leves(r=-0.405,P<0.05).Conclusion Serum Omentin-1 was related to insulin resistance.Serum Omentin-1 in serummay be a role indicator for impairment of renal function for diagnosis of type 2diabetic nephropathy.

参考文献/References:

[1] 许 戎.糖尿病肾病生物学标记物新进展[J].中华检验医学杂志,2015,38(9):583-585. Xu R.Recent progress of biomarkers for diabetic kidney disease[J].Chin J Lab Med,2015,38(9):583-585.
[2] 李浩彦,任 明.血清网膜素-1相关研究进展[J].中西医结合心脑血管病杂志,2016,14(7):722-725. Li HY,Ren M.Research progess in omentin-1[J].Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease,2016,14(7):722-725.
[3] Zhong X,Li X,Liu F,et al.Omentin inhibits TNF α induced expression of adhesion molecules in endothelial cells via ERK/NF κB pathway[J].Biochem Biophys Res Commun,2012,425(2):401-406.
[4] Li ZG,Liu BY,Zhao DW,et al.Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases[J].Biomedicine & Pharmacotherapy,2017,8(5):265-269.
[5] Yang HY,Ma Y,Lu XH,et al.The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome[J].Annalesd'Endocrinologie,2015,76(5):620-627.
[6] 李 宁,马豆豆,范志宏,等.糖尿病肾病患者血清网膜素-1水平变化[J]中国药物与临床,2016,16(11):1556-1559. Li N,Ma DD,Fan ZH,et al.Changes of serum omentin-1 in patientswith diabetic nephropathy[J].Chinese Remedies & Clinics,2016,16(11):1556-1559. 收稿日期:2017-11-23 修回日期:2018-01-15

相似文献/References:

[1]谭婷婷,程 莉,魏红霞,等.尿α1-酸性糖蛋白在早期糖尿病肾病诊断中的应用价值[J].现代检验医学杂志,2016,31(01):80.[doi:10.3969/j.issn.1671-7414.2016.01.023]
　TAN Ting-ting,CHENG Li,WEI Hong-xia,et al.Value of Urinary α1-Acid Glycoprotein in Early Diagnosis of Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(01):80.[doi:10.3969/j.issn.1671-7414.2016.01.023]
[2]热孜万古力·阿帕尔,吴 红.2型糖尿病肾病患者检测血清基质金属蛋白酶-10的意义[J].现代检验医学杂志,2016,31(03):111.[doi:10.3969/j.issn.1671-7414.2016.03.031]
　RIZWANGUL·Apaer,WU Hong.Study on the Significance of Detecting MMP-10 Level in Patients with Type 2 Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(01):111.[doi:10.3969/j.issn.1671-7414.2016.03.031]
[3]沈红艳a,邓演超a,徐 湛a,等.2型糖尿病肾病患者外周血IL-17和IL-22 mRNA水平[J].现代检验医学杂志,2015,30(02):30.[doi:10.3969/j.issn.1671-7414.2015.02.009]
　SHEN Hong-yana,DENG Yan-chaoa,XU Zhana,et al.Levels of IL-17 and IL-22 mRNA in the Blood of Type 2 Diabetic Nephropathy Patients[J].Journal of Modern Laboratory Medicine,2015,30(01):30.[doi:10.3969/j.issn.1671-7414.2015.02.009]
[4]武冬娜,张文杰,唐招平,等.血清Cys C和24h尿微量清蛋白定量联合检测对妊娠期糖尿病肾病的早期诊断价值[J].现代检验医学杂志,2015,30(02):139.[doi:10.3969/j.issn.1671-7414.2015.02.044]
　WU Dong-na,ZHANG Wen-jie,TANG Zhao-ping,et al.Diagnostic Value of Combined Measuring of Serum Cystatin C and 24 h Urine Microalbumin in Early Gestational Diabetes Kidney Disease[J].Journal of Modern Laboratory Medicine,2015,30(01):139.[doi:10.3969/j.issn.1671-7414.2015.02.044]
[5]高 科,陶 娟,范 宁,等.联合检测三种生化指标对糖尿病肾病早期诊断的临床价值分析[J].现代检验医学杂志,2016,31(04):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
　GAO Ke,TAO Juan,FAN Ning,et al.Analysis of Combined Detection of Three Kinds of Biochemical Indexes of Clinical Value for Early Diagnosis of Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(01):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
[6]姜繁明,董西华,李 花,等.血清25-(OH)D3与尿微量蛋白系列在糖尿病肾病中的联合应用[J].现代检验医学杂志,2016,31(04):143.[doi:10.3969/j.issn.1671-7414.2016.04.045]
　JIANG Fan-ming,DONG Xi-hua,LI Hua,et al.Joint Application of Serum 25-(OH)D3 and Urine Microprotein Series in Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(01):143.[doi:10.3969/j.issn.1671-7414.2016.04.045]
[7]张 宁,陆学东,吴正林.飞行时间质谱技术在糖尿病肾病患者尿蛋白成分分析中的研究进展[J].现代检验医学杂志,2016,31(05):160.[doi:10.3969/j.issn.1671-7414.2016.05.048]
　ZHANG Ning,LU Xue-dong,WU Zheng-lin.Research Advancement of TOF-MS for Analysising Protein Components in Patients with Diabetic Nephropathy Urine[J].Journal of Modern Laboratory Medicine,2016,31(01):160.[doi:10.3969/j.issn.1671-7414.2016.05.048]
[8]马钧,金一,王煜芳,等.尿胱抑素C在2型糖尿病肾病肾小管损伤早期诊断中的价值[J].现代检验医学杂志,2016,31(06):124.[doi:10.3969/j.issn.1671-7414.2016.06.036]
　MA Jun,JIN Yi,WANG Yu-fang,et al.Diagnosis Value of Urinary Cystatin C in Type 2 Diabetic Nephropathy Renal Tubular Injury[J].Journal of Modern Laboratory Medicine,2016,31(01):124.[doi:10.3969/j.issn.1671-7414.2016.06.036]
[9]杨宏秀,刘 丽,张会芬,等.血清抗中性粒细胞胞浆抗体及相关炎性因子检测对糖尿病肾病的诊断价值[J].现代检验医学杂志,2018,33(05):95.[doi:10.3969/j.issn.1671-7414.2018.05.025]
　YANG Hong-xiu,LIU Li,ZHANG Hui-fen,et al.Diagnostic Value of Detection Anti-Cardiolipin Antibodies and Related Inflammatory Factors in Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2018,33(01):95.[doi:10.3969/j.issn.1671-7414.2018.05.025]
[10]岳芳芳a,倪文娟a,冷小敏b,等.人白介素10荧光定量PCR检测方法的建立及其在糖尿病肾病中的表达研究[J].现代检验医学杂志,2019,34(04):11.[doi:10.3969/j.issn.1671-7414.2019.04.003]
　YUE Fang-fanga,NI Wen-juana,LENG Xiao-minb,et al.Establishment of Real-Time Quantitative PCR Assay for Human IL-10 and Its Expression in Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2019,34(01):11.[doi:10.3969/j.issn.1671-7414.2019.04.003]

备注/Memo

备注/Memo:
作者简介:赵 耕(1976-),男,主管技师,主要从事临床糖尿病检验工作。
更新日期/Last Update: 2018-02-07