[1]王 璐,李维娟,杨 靖.血清NT-proBNP和Cys-C水平联合检测在心力衰竭诊断与分型中的应用[J].现代检验医学杂志,2018,33(06):91-94.[doi:10.3969/j.issn.1671-7414.2018.06.024]
　WANG Lu,LI Wei-juan,YANG Jing.Application of Combined Detection of Serum NT-proBNP and Cys-C Levels in Diagnosis and Typing of Heart Failure[J].Journal of Modern Laboratory Medicine,2018,33(06):91-94.[doi:10.3969/j.issn.1671-7414.2018.06.024]
点击复制

血清NT-proBNP和Cys-C水平联合检测在心力衰竭诊断与分型中的应用()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
91-94
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Application of Combined Detection of Serum NT-proBNP and Cys-C Levels in Diagnosis and Typing of Heart Failure
文章编号:
1671-7414(2018)06-091-04
作者:
王 璐1; 李维娟2; 杨 靖1
1.乌鲁木齐市中医医院检验科,乌鲁木齐 830002; 2.新疆佳音医院实验室,乌鲁木齐 830000
Author(s):
WANG Lu1; LI Wei-juan2; YANG Jing1
1.Department of Clinical Laboratory,Xinjiang Urumqi Hospital of Traditional Chinese Medicine,Urumqi 830002,China; 2.Department of Clinical Laboratory,Xinjiang Jiayin Hospital,Urumqi 830000,China
关键词:
心力衰竭;  氨基末端B型脑钠肽;  胱抑素-C;  联合检测
分类号:
R541.6; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.06.024
文献标志码:
A
摘要:
目的 探讨血清氨基末端B型脑钠肽(NT-proBNP)和胱抑素-C( Cys-C)水平联合检测在心力衰竭诊断与分型中的应用。方法 选取心力衰竭诊断明确的75例患者为试验组,选取同期查体健康者75例为对照组。用双向侧流免疫法检测血清NT-proBNP水平; 用乳胶免疫比浊法检测Cys-C水平,通过统计学分析观察其差异性和相关性。结果 试验组血清NT-proBNP为816±338 pg/ml,Cys-C为1.28±0.34 mg/L,对照组血清NT-proBNP为38.2±19.9 pg/ml,Cys-C为0.72±0.17mg/L,试验组患者血清联合检测水平均高于对照组患者水平,差异均有统计学意义(t=33.6,12.6,均P<0.05); 试验组按NYHA心功能分级与对照组比较,差异均有统计学意义(F=43.2,26.6,均P<0.05); 血清NT-proBNP和Cys-C联合检测明显提高对心力衰竭诊断的敏感度和特异度,差异均有统计学意义(r=0.58,均P<0.05)。结论 血清NT-proBNP和Cys-C水平联合检测是心力衰竭诊断与分型的重要检测指标,为实验室心力衰竭诊断比较理想的应用组合。
Abstract:
Objective To investigate the application of combined detection of serum N-terminal B-type natriuretic peptide(NT-proBNP)and cystatin-C(Cys-C)in the diagnosis and classification of heart failure.Methods 75 patients with heart failure were selected as theexperimental group and 75 healthy subjects were selected as the control group.Serum NT-proBNP level was detected by bidirectional flow immunoassay,and Cys-Clevel was detected by latex immunoturbidimetry.The difference and correlationwere observed by statistical analysis.Results The levelsof NT-proBNP and Cys-C in the experimental group and the control group were 816±338 pg/ml,1.28±0.34 mg/L; 38.2±19.9 pg/ml,0.72±0.17 mg/L respectively.Compared with the control group,the difference of functional classificationwas statistically significant(F=43.2,26.6,all P<0.05),and the combined detection of NT-proBNP and Cys-C significantly increased the sensitivityand specificity of the diagnosis of heart failure(r=0.58,all P<0.05).Conclusion The combined detection of serum NT-proBNPand Cys-C levels is an important index for the diagnosis and typing of heart failure,and is an ideal combination for laboratory diagnosis of heart failure.

参考文献/References:

[1] 窦 伟,李 燕,刘元生.急诊舒张性心衰患者心律失常的类型及机制[J].临床心电学杂志,2017,26(1):27-30.
Dou W,Li Y,Liu YS.Types and mechanism of arrhythmia in patients with diastolic heart failure in emergency department[J].J Clinical Electrophysiology,2017,26(1):27-30.
[2] 赵建军,朱 武.血清胱抑素C、同型半胱氨酸及尿微量清蛋白/肌酐比值在糖尿病肾病早期诊断中的应用[J].现代检验医学杂志,2014,29(2):117-120.
Zhao JJ,Zhu W.Application of serum cystatin C,homocysteine,the ratio between microalbuminuria and creatinine in the early diagnosis of the diabetic nephrosis[J].Journal of Modern Laboratory Medicine,2014,29(2):117-120.
[3] Satoh K.Cyclophilin a in cardiovascular homeostasis and diseases[J].The Tohoku Journal of Experimental Medicine,2015,235(1):1-15.
[4] 李小侠,詹 颉,张 华,等.N-端脑钠肽前体测定在高血压疾病中的应用研究[J].现代检验医学杂志,2016,31(5):100-102.
Li XX,Zhan J,Zhang H,et al.Application on NT-proBNP in patientswith essential hypertension[J].Journal of Modern Laboratory Medicine,2016,31(5):100-102.
[5] 王智明.急性失代偿性心衰患者NTpro-BNP/BNP与NTpro-BNP,BNP对患者预后的预测价值比较[J].中国医药导报,2016,13(2):16-19.
Wang ZM.Comparison of predicting value of NTpro-BNP/BNP,NTpro-BNP and BNP of patients with acute decompensated heart failure prognosis[J].China Medical Herald,2016,13(2):16-19.
[6] Yassine HN,Trenchevska O,Dong Z,et al.The association of plasma cystatin C proteoforms with diabetic chronic kidney disease[J].Proteome Science,2016,14:7.
[7] Safdar OY,Shalaby M,Khathlan N,et al.Serum cystatin is a useful marker for the diagnosis of acute kidney injury in critically ill children:prospective cohort study[J].BMG Nephrol,2016,17(1):130.
[8] Sakuragi S,Ichikawa K,Yamada K,et al.Serun cystatin C level is associated with left atrial enlargement,left ventricular hypertrophy and impaired left ventricular relaxation in patients with stage 2 or 3 chronic kidney disease[J].Int J Cardiol,2015,190:287-292.
[9] Hadjiphilippou S,Kon SP.Cardiorenal syndrome:review of our current understanding[J].J R Soc Med,2016,109(1):12-17.
[10] 肖本胜,郭 涛.心力衰竭严重程度与生化指标的关系[J].慢性病学杂志,2013,14(11):837-840.
Xiao BS,Guo T.Relationship between the severity of heart failure and biochemical traits[J].Chronic Pathematology Journal,2013,14(11):837-840.

相似文献/References:

[1]丁春梅,胡志德,刘晓斐,等.MR-proANP：一种新型心力衰竭诊断标志物[J].现代检验医学杂志,2015,30(05):99.[doi:10.3969/j.issn.1671-7414.2015.05.0030]
　DING Chun-mei,HU Zhi-de,LIU Xiao-fei,et al.MR-proANP：A Novel Diagnostic Marker for Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(06):99.[doi:10.3969/j.issn.1671-7414.2015.05.0030]
[2]闫福堂,苏宝凤,詹颉,等.血清可溶性ST2与血BNP在心力衰竭患者中的相关性研究[J].现代检验医学杂志,2015,30(06):78.[doi:10.3969/j.issn.1671-7414.2015.06.022]
　YAN Fu-tang,SU Bao-feng,ZHAN Jie,et al.Correlation between Serum Soluble ST2 and BNP in Patients with Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(06):78.[doi:10.3969/j.issn.1671-7414.2015.06.022]
[3]屈慧,李娅,黄瑶楠,等.心力衰竭患者外周血RDW 和NT-pro-BNP 联合检测对临床诊断及分级的相关性研究[J].现代检验医学杂志,2020,35(05):65.[doi:10.3969/j.issn.1671-7414.2020.05.017]
　QU Hui,LI Ya,HUANG Yao-nan,et al.Correlation Study on the Combined Detection of RDW and NT-Pro-BNP in Patients with Heart Failure to Clinical Diagnosis and Grading[J].Journal of Modern Laboratory Medicine,2020,35(06):65.[doi:10.3969/j.issn.1671-7414.2020.05.017]
[4]胡小燕,郑　晓,嵇华夏,等.血清 PCT 与 BNP 水平联合检测对慢性阻塞性肺疾病急性加重期并发心力衰竭的临床诊断价值[J].现代检验医学杂志,2021,36(03):128.[doi:10.3969/j.issn.1671-7414.2021.03.029]
　HU Xiao-yan,ZHENG Xiao,JI Hua-xia,et al.Clinical Diagnostic Value of Combined Detection of Serum PCT and BNPLevels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Heart Failure[J].Journal of Modern Laboratory Medicine,2021,36(06):128.[doi:10.3969/j.issn.1671-7414.2021.03.029]
[5]李志强,吴正霞,陈　凯,等.心力衰竭患者并发甲型流感的临床和实验室特征分析[J].现代检验医学杂志,2021,36(03):137.[doi:10.3969/j.issn.1671-7414.2021.03.031]
　LI Zhi-qianga,WU Zheng-xiaa,CHEN Kaia,et al.Analysis on the Clinical and Laboratory Characteristics of Heart FailurePatients with Influenza A[J].Journal of Modern Laboratory Medicine,2021,36(06):137.[doi:10.3969/j.issn.1671-7414.2021.03.031]
[6]杨　英,吴　翔,张文华,等.川芎嗪通过调控组蛋白乙酰化修饰上调SERCA2a对心力衰竭小鼠模型的防治机制研究[J].现代检验医学杂志,2021,36(06):34.[doi:10.3969/j.issn.1671-7414.2021.06.007]
　YANG Ying,WU Xiang,ZHANG Wen-hua,et al.Research on Prevention and Control Mechanism of the Ligustrazine Up Regulates SERCA2a by Regulating Histone Acetylation in A Mouse Model of Heart Failure[J].Journal of Modern Laboratory Medicine,2021,36(06):34.[doi:10.3969/j.issn.1671-7414.2021.06.007]
[7]李丽霞,李 娜.血清MAO 和IL-6 水平诊断慢性肾衰竭并发心力衰竭的价值及与心功能分级的关系[J].现代检验医学杂志,2023,38(01):147.[doi:10.3969/j.issn.1671-7414.2023.01.027]
　LI Li-xia,LI Na.Value of Serum MAO and IL-6 Levels in the Diagnosis of Chronic Renal Failure Complicated with Heart Failure and Their Relationship with Cardiac Function Grading[J].Journal of Modern Laboratory Medicine,2023,38(06):147.[doi:10.3969/j.issn.1671-7414.2023.01.027]
[8]张 囝a,徐钰行b,骆宇琛c,等.重症肺炎脓毒症患者血清Sestrin2，TLR7 水平表达及对心力衰竭的预测价值分析[J].现代检验医学杂志,2024,39(03):131.[doi:10.3969/j.issn.1671-7414.2024.03.022]
　ZHANG Jiana,XU Yuxingb,LUO Yuchenc,et al.Analysis of Serum Sestrin2 and TLR7 Level Expression in Patients with Severe Pneumonic Sepsis and Predictive Value for Heart Failure[J].Journal of Modern Laboratory Medicine,2024,39(06):131.[doi:10.3969/j.issn.1671-7414.2024.03.022]

备注/Memo

备注/Memo:
作者简介:王 璐(1980-),女,本科,主管检验技师,主要从事生物化学检验研究,E-mail:lulu4014@126.com。
通讯作者:杨 靖(1973-),男,本科,副主任检验技师,E-mail:250674354qq.com。
更新日期/Last Update: 2018-11-30