[1]李丽霞,李 娜.血清MAO 和IL-6 水平诊断慢性肾衰竭并发心力衰竭的价值及与心功能分级的关系[J].现代检验医学杂志,2023,38(01):147-150+164.[doi:10.3969/j.issn.1671-7414.2023.01.027]
　LI Li-xia,LI Na.Value of Serum MAO and IL-6 Levels in the Diagnosis of Chronic Renal Failure Complicated with Heart Failure and Their Relationship with Cardiac Function Grading[J].Journal of Modern Laboratory Medicine,2023,38(01):147-150+164.[doi:10.3969/j.issn.1671-7414.2023.01.027]
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血清MAO 和IL-6 水平诊断慢性肾衰竭并发心力衰竭的价值及与心功能分级的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年01期
页码:
147-150+164
栏目:
论著
出版日期:
2023-01-15

文章信息/Info

Title:
Value of Serum MAO and IL-6 Levels in the Diagnosis of Chronic Renal Failure Complicated with Heart Failure and Their Relationship with Cardiac Function Grading
文章编号:
1671-7414（2023）01-147-05
作者:
李丽霞;  李 娜
（邯郸明仁医院检验科，河北邯郸 056002）
Author(s):
LI Li-xia;  LI Na
（Department of Clinical Laboratory, Handan Mingren Hospital，Hebei Handan 056002，China）
关键词:
心力衰竭; 心功能分级; 单胺氧化酶; 慢性肾衰竭
分类号:
R692.5；R392.11
DOI:
10.3969/j.issn.1671-7414.2023.01.027
文献标志码:
A
摘要:
目的 研究血清单胺氧化酶（monoamine oxidase，MAO）、白细胞介素（interleukin，IL）-6 水平与慢性肾衰竭（chronic renal failure）并发心力衰竭（heart failure）患者心功能分级的相关性。方法 选择2021 年6 月～ 2022年5 月邯郸明仁医院肾病科及透析中心慢性肾衰竭并发心力衰竭患者80 例作为试验组，按照美国纽约心脏病学会（New York Heart Association，NYHA）分级将试验组患者分为：心功能I 级20 例，心功能II 级20 例，心功能III 级20 例和心功能IV 级20 例，同期选择单纯慢性肾衰竭患者80 例作为对照A 组，健康体检者80 例作为对照B 组，分别测定各组的血清MAO，IL-6 和N- 末端B 型钠尿肽前体（N-terminal B-type natriuretic peptide precursor，NTproBNP）水平，分析其与慢性肾衰竭并发心力衰竭患者心功能分级的关系。其中试验组、对照A 组符合疾病诊断标准，经各项检查确诊，且病情稳定，实验前均未接受治疗，另外所有观察对象与家属签订知情书。结果 试验组MAO（8.56±1.85U/L），IL-6（128.56±17.48ng/L）和NT-proBNP（872.04±11.25pg/ml）水平均高于对照A 组（3.14±1.01U/L，97.42±12.36ng/L，195.79±6.87pg/ml） 和对照B 组（2.87±0.85U/L，77.69±8.15ng/L，66.04±5.48pg/ml）， 差异均具有统计学意义（F=478.790，300.850，220 577.310，均 P ＜ 0.05）。心功能I 级MAO，IL-6，NT-proBNP 水平分别为3.77±1.05U/L，104.26±15.47ng/L 和381.25±8.44pg/ml， 心功能II 级MAO，IL-6，NT-proBNP 水平分别为5.26±1.35U/L，113.15±16.89ng/L 和579.31±10.10pg/ml，心功能III 级MAO，IL-6，NT-proBNP 水平分别为7.48±2.09U/L，125.73±17.02ng/L 和782.08±11.24pg/ml， 心功能IV 级MAO，IL-6，NT-proBNP 水平分别为8.99±2.67U/L，130.58±17.96ng/L，901.54±12.10pg/ml，试验组中心功能IV 级患者的血清MAO，IL-6，NT-proBNP 水平均高出心功能I，II，III 级患者，差异具有统计学意义（F=29.750，172.220，9 414.430, 均P ＜ 0.05）。联合诊断的敏感度（97.50%）、特异度（95.00%）、ROC 曲线下面积（0.893）高出单一MAO（86.25%，83.75%，0.600）和IL-6（87.50%，83.75%，0.580），差异具有统计学意义（χ2=0.004，7.207，6.664，均P ＜ 0.05）。血清MAO，IL-6，NT-proBNP 指标均与慢性肾衰竭并发心力衰竭患者心功能分级呈现正相关性（r=0.562 ～ 0.781，P ＜ 0.05）。结论 血清MAO，IL-6 与慢性肾衰竭并发心力衰竭患者心功能分级存在密切关联性，不仅能够诊断疾病，同时还可对心功能分级进行评估，另外联合诊断的敏感度以及特异度更高。
Abstract:
Objective To study the correlation of serum monoamine oxidase (MAO) and interleukin-6 (IL-6) levels with cardiac function classifications in chronic renal failure patients with heart failure. Methods 80 chronic renal failure patients with heart failure treated from June 2021 to May 2022 in Nephrology and Dialysis Department of Handan Mingren Hospital were chosen as experimental group. According to New York Heart Association (NYHA), the experimental group was assigned to grade I group (20 cases), grade II group (20 cases), grade III group (20 cases) and grade IV group (20 cases). Over the same time period, 80 chronic renal failure patients were set as control group A. 80 healthy checkups were set as control group B. Serum MAO, IL-6 and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured, and analyze its correlations with cardiac function classifications. Among them, the test group and the control group A met the disease diagnostic criteria; were confirmed by various examinutions, and were in a stable comdition, and did not receive treatment before the experiment. In addition, all the observation objects signed a love letter with their familes receive the therapy; the research subjects and their family members had signed the informed consent forms. Results Serum MAO(8.56±1.85U/L), IL-6(128.56±17.48ng/L ) and NT-proBNP (872.04±11.25pg/ml) levels in the experimental group were, and which were significantly higher than those of control group A (3.14±1.01U/L, 97.42±12.36ng/L, 195.79±6.87pg/ml)]and control group B (2.87±0.85U/L, 77.69±8.15ng/L, 66.04±5.48pg/ml)]，the differences were statistically significant（F=478.790，300.850，220 577.310，all P ＜ 0.05）. Serum MAO, IL-6 and NT-proBNP levels in grade I group were 3.77±1.05U/L, 104.26±15.47ng/L and 381.25±8.44pg/ml， respectively. Serum MAO, IL-6 and NT-proBNP levels in grade II group were 5.26±1.35U/L, 113.15±16.89ng/L and 579.31±10.10pg/ml，respectively. Serum MAO,IL-6 and NT-proBNP levels in grade III group were 7.48±2.09U/L, 125.73±17.02ng/L and 782.08±11.24pg/ml，respectively. Serum MAO, IL-6 and NT-proBNP levels in grade IV group were 8.99±2.67U/L, 130.58±17.96ng/L and 901.54±12.10 pg/ml，respectively. Serum MAO, IL-6 and NT-proBNP levels in grade IV group were significantly higher than grade I group, grade II group and grade III group （F=29.750，172.220，9 414.430, all P ＜ 0.05）. The diagnosis sensitivity（97.50%）, specificity（95.00%） and area under ROC（0.893） curve based on combined examination were higher than those based on MAO（86.25%，83.75%，0.600） or IL-6（87.50%，83.75%，0.580）, the differences were statistically significant（χ2=0.004，7.207，6.664，all P ＜ 0.05）.Serum MAO, IL-6 and NT-proBNP levels were positively correlated with cardiac function classifications for chronic renal failure patients with heart failure (r=0.562 ～ 0.781，all P ＜ 0.05). Conclusion Serum MAO and IL-6 levels were closely correlated with cardiac function classifications in chronic renal failure patients with heart failure, which can make for disease diagnosis and evaluate the cardiac function classifications; the diagnosis sensitivity and specificity based on combined examination are higher than single examination.

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备注/Memo

备注/Memo:
基金项目：河北省卫生健康委医学课题计划项目（20211402）。
作者简介：李丽霞（1980-），女，汉族，本科，主管检验师，研究方向：临床检验。
通讯作者：李娜（1981-），女，本科，主管检验师，E-mail：65493777@qq.com。
更新日期/Last Update: 2023-01-15