[1]王 璐,李维娟,杨 靖.血清NT-proBNP和Cys-C水平联合检测在心力衰竭诊断与分型中的应用[J].现代检验医学杂志,2018,33(06):91-94.[doi:10.3969/j.issn.1671-7414.2018.06.024]
　WANG Lu,LI Wei-juan,YANG Jing.Application of Combined Detection of Serum NT-proBNP and Cys-C Levels in Diagnosis and Typing of Heart Failure[J].Journal of Modern Laboratory Medicine,2018,33(06):91-94.[doi:10.3969/j.issn.1671-7414.2018.06.024]
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血清NT-proBNP和Cys-C水平联合检测在心力衰竭诊断与分型中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
91-94
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Application of Combined Detection of Serum NT-proBNP and Cys-C Levels in Diagnosis and Typing of Heart Failure
文章编号:
1671-7414(2018)06-091-04
作者:
王 璐1; 李维娟2; 杨 靖1
1.乌鲁木齐市中医医院检验科,乌鲁木齐 830002; 2.新疆佳音医院实验室,乌鲁木齐 830000
Author(s):
WANG Lu1; LI Wei-juan2; YANG Jing1
1.Department of Clinical Laboratory,Xinjiang Urumqi Hospital of Traditional Chinese Medicine,Urumqi 830002,China; 2.Department of Clinical Laboratory,Xinjiang Jiayin Hospital,Urumqi 830000,China
关键词:
心力衰竭;  氨基末端B型脑钠肽;  胱抑素-C;  联合检测
分类号:
R541.6; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.06.024
文献标志码:
A
摘要:
目的 探讨血清氨基末端B型脑钠肽(NT-proBNP)和胱抑素-C( Cys-C)水平联合检测在心力衰竭诊断与分型中的应用。方法 选取心力衰竭诊断明确的75例患者为试验组,选取同期查体健康者75例为对照组。用双向侧流免疫法检测血清NT-proBNP水平; 用乳胶免疫比浊法检测Cys-C水平,通过统计学分析观察其差异性和相关性。结果 试验组血清NT-proBNP为816±338 pg/ml,Cys-C为1.28±0.34 mg/L,对照组血清NT-proBNP为38.2±19.9 pg/ml,Cys-C为0.72±0.17mg/L,试验组患者血清联合检测水平均高于对照组患者水平,差异均有统计学意义(t=33.6,12.6,均P<0.05); 试验组按NYHA心功能分级与对照组比较,差异均有统计学意义(F=43.2,26.6,均P<0.05); 血清NT-proBNP和Cys-C联合检测明显提高对心力衰竭诊断的敏感度和特异度,差异均有统计学意义(r=0.58,均P<0.05)。结论 血清NT-proBNP和Cys-C水平联合检测是心力衰竭诊断与分型的重要检测指标,为实验室心力衰竭诊断比较理想的应用组合。
Abstract:
Objective To investigate the application of combined detection of serum N-terminal B-type natriuretic peptide(NT-proBNP)and cystatin-C(Cys-C)in the diagnosis and classification of heart failure.Methods 75 patients with heart failure were selected as theexperimental group and 75 healthy subjects were selected as the control group.Serum NT-proBNP level was detected by bidirectional flow immunoassay,and Cys-Clevel was detected by latex immunoturbidimetry.The difference and correlationwere observed by statistical analysis.Results The levelsof NT-proBNP and Cys-C in the experimental group and the control group were 816±338 pg/ml,1.28±0.34 mg/L; 38.2±19.9 pg/ml,0.72±0.17 mg/L respectively.Compared with the control group,the difference of functional classificationwas statistically significant(F=43.2,26.6,all P<0.05),and the combined detection of NT-proBNP and Cys-C significantly increased the sensitivityand specificity of the diagnosis of heart failure(r=0.58,all P<0.05).Conclusion The combined detection of serum NT-proBNPand Cys-C levels is an important index for the diagnosis and typing of heart failure,and is an ideal combination for laboratory diagnosis of heart failure.

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备注/Memo

备注/Memo:
作者简介:王 璐(1980-),女,本科,主管检验技师,主要从事生物化学检验研究,E-mail:lulu4014@126.com。
通讯作者:杨 靖(1973-),男,本科,副主任检验技师,E-mail:250674354qq.com。
更新日期/Last Update: 2018-11-30