[1]段侠霞,陈英,沈德华,等.儿童及青少年精神分裂症患者血清同型半胱氨酸、叶酸水平与PANSS评分的关系研究[J].现代检验医学杂志,2019,34(01):104-106.[doi:10.3969/j.issn.1671-7414.2019.01.027]
　DUAN Xia-xia,CHEN Ying,SHEN De-hua,et al.Correlation Study between Serum Homocysteine，Folic Acid Levels and PANSS Score in Children and Adolescents Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2019,34(01):104-106.[doi:10.3969/j.issn.1671-7414.2019.01.027]
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儿童及青少年精神分裂症患者血清同型半胱氨酸、叶酸水平与PANSS评分的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
104-106
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Correlation Study between Serum Homocysteine，Folic Acid Levels and PANSS Score in Children and Adolescents Patients with Schizophrenia
文章编号:
1671- 7414(2019)01-104-03
作者:
段侠霞; 陈英; 沈德华; 杨愉晨; 马瑾; 贺瑞峰
(西安市精神卫生中心检验科，西安710100)
Author(s):
DUAN Xia-xia; CHEN Ying; SHEN De-hua; YANG Yu-chen;  MA Jin; HE Rui-feng
(Department of Clinical Laboratory，Xi’an Mental Health Center， Xi’an 710100，China)
关键词:
儿童青少年; 同型半胱氨酸; 叶酸; 精神分裂症; 相关性
分类号:
R749.3；R446.112
DOI:
10.3969/j.issn.1671-7414.2019.01.027
文献标志码:
A
摘要:
目的探讨儿童及青少年精神分裂症患者血清同型半胱氨酸 (homocysteine，Hcy)、叶酸水平与阳性和阴性症状量表(positive and negative symptoms scale，PANSS)评分的相关性。方法采用病例-对照的研究方法。 选取西安市精神卫生中心儿少心理科2017年4月～2018年7月期间的100例精神分裂症患者作 为病例组，同时选取口腔医院120例健康体检患者作为对照组。分析两组患者的血清同型半 胱氨酸(Hcy)、叶酸水平，并采用阳性和阴性症状量表(positive and negative symptoms s cales，PANSS)评定患者病情的严重程度。结果①病例组的叶酸水 平为7.98±6.39 ng/ml，Hcy水平为28.47±23.41 μmol/L，对照组的叶酸水平为11.1 4±4.52 ng/ml，Hcy水平为14.57±4.27 μmol/L。病例组的叶酸水平明显低于对照组， Hcy水平明显高于对照组，差异均具有统计学意义( t=2.433，P＜0.05；t=3.459，P ＜0.01)；②病例组患者的PANSS评分与Hcy水平呈正相关( r=0.440，P ＜0.01)，PANS S阴性评分与叶酸水平呈负相关( r=－0.346，P ＜0.05)，Hcy水平与叶酸水平呈负相关 ( r=－0.497，P ＜0.01)。结论儿童及青少年精神分裂症患者 血清Hcy，叶酸水平和PANSS评分有密切的关系。
Abstract:
Objective To observe the correlation between se rum homocysteine (Hcy)，folic acid levels and positive and negative symptoms sca le (PANSS) score in children and adolescents patients with schizophrenia． Methods The case-control method was used in this study．100 p atients with schizophrenia in the Department of Children and Adolescents Psychol ogy in Xi’an Mental Health Center were selected as the case group from April 20 17 to July 2018，and 120 healthy people in the Oral Hospital were selected as th e control group．The levels of serum Hcy，folic acid were analyzed and the patie nts of case group were assessed using positive and negative symptoms scales (PAN SS)．Results ①The levels of serum folic acid and Hcy for case group were 7.98±6.39 ng/ml and 28.47±23.41 μmol/L，and the levels o f serum folic acid and Hcy for control group were 11.14±4.52 ng/ml and 14.57 ±4.27 μmol/L．The levels of serum folic acid were significantly lower and the levels of serum Hcy were significantly hig her in case group compare with contorol group，the difference was statistically significant ( t=2.433，P＜0.05；t=3.459，P ＜0.01)．②A positive correlat ion existed between PANSS scores and Hcy levels ( r=0.440，P ＜0.01)，and a negative correlation existed between negative symptoms scores and folic acid lev els ( r=－0.346，P ＜0.05)，and a negative correlation existed between serum Hcy and folic acid levels ( r=－0.497，P ＜0.01)．Conclusion There was a relationship between ser u m Hcy，folic acid levels and PANSS score in children and adolescents patients wi th schizophrenia．

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备注/Memo

备注/Memo:

作者简介：段侠霞(1982-)，女，硕士，主管检验技师， 主要从事临床检验诊断学的研究，E-mail：690482552@qq.com。
通讯作者：贺瑞峰(1984-)，男，硕士，主管检验技师，主要从事 临床检验诊断和精神病学，E-mail：rfhe1984@163.com。
更新日期/Last Update: 2019-02-28