[1]吴爽,张书婉,张涛元,等.西安地区0～12岁健康儿童血清S100蛋白参考区间的建立[J].现代检验医学杂志,2019,34(01):124-126.[doi:10.3969/j.issn.1671-7414.2019.01.032]
　WU Shuang,ZHANG Shu-wan,ZHANG Tao-yuan,et al.Establishment of Biology Reference Interval of Serum Protein S100 Level in Healthy Children between 0 and 12 Years Old in Xi’an[J].Journal of Modern Laboratory Medicine,2019,34(01):124-126.[doi:10.3969/j.issn.1671-7414.2019.01.032]
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西安地区0～12岁健康儿童血清S100蛋白参考区间的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
124-126
栏目:
研究简报·实验技术
出版日期:
2019-02-28

文章信息/Info

Title:
Establishment of Biology Reference Interval of Serum Protein S100 Level in Healthy Children between 0 and 12 Years Old in Xi’an
文章编号:
1671-7414(2019) 01-124-03
作者:
吴爽1; 张书婉1; 张涛元2; 陈露1; 曹三成1;  李俏1
(1.西安市儿童医院检验科，西安710003；2.日照心脏病医院，山东日 照276800)
Author(s):
WU Shuang1; ZHANG Shu-wan1; ZHANG Tao-yuan2; CH EN Lu1; CAO San-cheng1; LI Qiao1
(1.Department of Clinical Laboratory，Xi’an Children’s Hospita l，Xi’an，710003，China； 2.Rizhao Heart Hospital，Shandong Rizhao 276800，China)
关键词:
S100蛋白; 儿童; 参考区间; 颅脑损伤
分类号:
R446.11
DOI:
10.3969/j.issn.1671-7414.2019.01.032
文献标志码:
A
摘要:
目的建立西安地区0～12岁健康儿童血清S100蛋白的参考 区间。方法选择2018年7月1日起在西安市儿童医院儿保科健康体检 的125例不同年龄、性别分布的健康儿童，使用西安金磁纳米生物技术公司的磁定量免疫分 析仪及其配套试剂测定血清S100蛋白水平。按照《中华人民共和国卫生行业标准WST-402- 2012》文件所规定的方法，分析、建立并验证血清S100蛋白参考区间。结果 西安地区0～12岁儿童血清S100蛋白水平呈偏态分布；不同性别间血清S100蛋白差 异无统计学意义( P ＞0.05)；不同年龄分组间血清S100蛋白差异无统计学意义( P ＞ 0.05)；0～12岁儿童血清S100蛋白参考区间为：血清S100≤270.375 5 pg/ml。 结论实验室根据现有检测系统，建立了西安地区0～12岁健康儿童的血清S10 0蛋白参考区间，为临床疾病的诊断奠定了基础。
Abstract:
Objective To establish biology reference interval of serum protein S100 level in children between 0 and 12 years old in Xi’an．Methods Serum protein S100 level were dectected i n 125 children from 0～12 years by GoldMag Lateral Flow Immunoassy analysis syst em．The S100 protein reference interval was analyzed，established and validated in accordance with the methods specified in the “People’s Republic of China He alth Industry Standard WST-402-2012”．Results Serum S1 00 protein levels in children aged 0～12 years in Xi’an were skewed．And withou t significant difference between different genders and ages ( P >0.05)．The r eference range of serum S100 protein in children aged 0～12 was S100≤270.375 5 pg/ml．Conclusion Based on the existing detection system ，the laboratory established a serum S100 protein reference interval for childre n aged 0～12 years，which laid the foundation for the diagnosis of clinical dise ases．

参考文献/References:


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备注/Memo

备注/Memo:
基 金项目：西安市科技局项目(J201702019 Ⅱ热休克蛋白HSP70与HBV PreS1作用并 介导HBV黏附入侵的相关研究)。
作者简介：吴爽(1990-)，女，硕士，初级检验师，研究方向： HBV黏附相关性研究，E-mail：395480829@qq.com。
通讯作者：李俏(1988-)，女，博士，中级检验师，研究方向： 病原微生物，E-mail：wschildren@163.com。
更新日期/Last Update: 2019-02-28