[1]王 蓉,蔡高涛,钟小青,等.血清AFP-L3和GP-73联合检测对原发性肝癌诊断的Meta分析[J].现代检验医学杂志,2019,34(02):72-75.[doi:10.3969/j.issn.1671-7414.2019.02.019]
　WANG Rong,CAI Gao-tao,ZHONG Xiao-qing,et al.Meta Analysis of Combined Detection of Serum AFP-L3and GP-73 in Diagnosis of Primary Liver Cancer[J].Journal of Modern Laboratory Medicine,2019,34(02):72-75.[doi:10.3969/j.issn.1671-7414.2019.02.019]
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血清AFP-L3和GP-73联合检测对原发性肝癌诊断的Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
72-75
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Meta Analysis of Combined Detection of Serum AFP-L3and GP-73 in Diagnosis of Primary Liver Cancer
文章编号:
1671-7414(2019)02-072-05
作者:
王 蓉1; 蔡高涛1; 钟小青1; 崔剑锋1; 刘春永2; 杜利军1; 黄宪章2
(1.广州花都区人民医院检验科,广州 510800; 2.广东省中医医院检验科,广州 510120)
Author(s):
WANG Rong1; CAI Gao-tao1; ZHONG Xiao-qing1; CUIJian-feng1; LIU Chun-yong2; DU Li-jun1; HUANG Xian-zhang2
(1.Department of Clinical Laboratory,Huadu District People's Hospital ofGuangzhou,Guangzhou 510800,China; 2.Department of Clinical Labortory,GuangdongProvincial Hospital Inspection Division of Traditional Chinese Medicine,Guangzhou 510120,China)
关键词:
肝癌;  甲胎蛋白异质体L3;  高尔基体糖蛋白73;  Meta分析;  诊断
分类号:
R735.7; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.02.019
文献标志码:
A
摘要:
目的 通过Meta分析及系统评价评估甲胎蛋白异质体L3(AFP-L3)和高尔基体糖蛋白73(GP73)联合检测诊断原发性肝癌的诊断价值。方法通过计算机检索和手工查询获得AFP-L3和GP73联合检测诊断原发性肝癌的文献,通过纳入和排除标准筛选文献并提取数据。采用Meta Disc1.4软件检验研究间异质性,并对诊断准确度指标进行Meta分析,绘制综合受试者工作特性曲线(SROC)。结果AFP-L3和GP73联合检测诊断原发性肝癌的汇总灵敏度、特异度和诊断优势比分别为0.86(95% CI:0.82～0.89),0.95(95% CI:0.93～0.96)和155.20(95% CI:57.47～419.1)。SROC曲线下面积(AUC)为0.981 2,Q指数为0.939 4。结论AFP-L3和GP73联合检测在原发性肝癌的诊断中具有较高的灵敏度及准确性,可作为诊断原发性肝癌的重要指标。
Abstract:
Objective To investigate the clinical value of combined detection of serum Golgi protein73(GP73)and AFP-L3 in the diagnosisof primary liver cancer.Methods Comprehensive electronic and manual searches were performed to retrieve relevant studies on the combined detection of serum AFP-L3 and GP-73 in diagnosis of primary liver cancer.After screening of the studies according to inclusion criteria and extraction of the data,meta-analysis was performed in Meta-disc 1.4 and Stata 14.0.Results Six studies that met the inclusion criteria were selected from the total 168 references with potential relevance.The threshold effect was found in the combined detection of serum AFP-L3 and GP-73in diagnosis of primary liver cancer.However,heterogeneity was found in this meta-analysis.The pooled sensitivity and specificity of AFP-L3 combined withGP-73 was 0.86(95% CI:0.82～0.89),0.95(95% CI:0.93～0.96)and 155.20(95%CI:57.47～419.1),respectively.The area under summary receiver operating characteristics curve was 0.981 2,and the Q index was 0.939 4.Conclusion AFP-L3 combined with GP73 can significantly improve the diagnostic sensitivity and specificity to a high level,and can improve the diagnosis rate of Primary liver cancer.

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备注/Memo

备注/Memo:
作者简介:王 蓉(1979-),女,项士学位,主管技师,研究方向:早期诊断肝癌的标志物研究,E-mail:8813210@qq.com。 收稿日期:2019-02-05 修回日期:2019-02-23 页码：75+78
更新日期/Last Update: 2019-04-30