[1]吴曼莉,赵 敏,袁 媛.妊娠期高血糖患者血浆同型半胱氨酸水平和脐动脉血流参数改变的相关性[J].现代检验医学杂志,2019,34(03):96-98,103.[doi:10.3969/j.issn.1671-7414.2019.03.023]
　WU Man-li,ZHAO Min,YUAN Yuan.Correlation Analysis of Homocysteine and Changes in Umbilical Arterialwith Color Doppler Ultrasound with Gestational Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2019,34(03):96-98,103.[doi:10.3969/j.issn.1671-7414.2019.03.023]
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妊娠期高血糖患者血浆同型半胱氨酸水平和脐动脉血流参数改变的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
96-98,103
栏目:
论著
出版日期:
2019-06-20

文章信息/Info

Title:
Correlation Analysis of Homocysteine and Changes in Umbilical Arterialwith Color Doppler Ultrasound with Gestational Diabetes Mellitus
文章编号:
1671-7414(2019)03-096-04
作者:
吴曼莉; 赵 敏; 袁 媛
(汉中市中心医院产科,陕西汉中 723000)
Author(s):
WU Man-li; ZHAO Min; YUAN Yuan
(Department of Obstetrics,Hanzhong Central Hospital,Shaanxi Hanzhong 72300,China)
关键词:
同型半胱氨酸;  糖尿病;  妊娠期糖尿病;  脐动脉血流参数
分类号:
R714.256; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.03.023
文献标志码:
A
摘要:
目的 探讨妊娠期高血糖患者血浆同型半胱氨酸(homocysteine,Hcy)与脐动脉血流参数改变的相关性。方法 收集2017年1月～2018年6月于汉中市中心医院产科住院的孕妇共210例,其中正常晚期孕妇(NC组)75例,妊娠期糖尿病孕妇(GDM组)65例,孕前糖尿病孕妇(PGDM组)70例,分别检测并比较各组孕妇血清Hcy水平及脐动脉血流[收缩末期最大血流速度与舒张期最大血流速度之比(S/D),阻力指数(RI)及搏动指数(PI)],并分析脐动脉血流与血浆Hcy水平的相关性。结果 三组孕妇临床资料比较差异无统计学意义(F=0.559～0.950,P>0.05)。PGDM组、GDM组与NC组血清Hcy水平分别为10.33±1.78,6.78±1.31和3.89±1.21 μmol/L,各组之间比较差异具有统计学意义(F=27.66,P=0.000)。PGDM组、GDM组与NC组S/D分别为3.91±0.75,3.22±0.64和2.71±0.46; RI分别为0.80±0.06,0.63±0.06和0.51±0.05; PI分别为1.42±0.71,1.12±0.29和0.65±0.33,各组之间差异均具有统计学意义(F=6.765,4.398,7.890; P=0.005,0.013,0.002)。PGDM组孕妇血清Hcy与脐动脉血流参数S/D,RI,PI呈正相关(r=0.801,0.719,0.459; P=0.001,0.002,0.021)。GDM组血清Hcy与脐动脉血流参数S/D,RI,PI呈正相关(r=0.559,0.592,0.311; P=0.008,0.007,0.002)。结论 Hcy在孕期高血糖患者(包括妊娠期糖尿病及孕前糖尿病)中明显升高,孕前糖尿病患者S/D水平明显升高。降低Hcy、监测S/D可能是治疗妊娠期高血糖的措施之一。
Abstract:
Objective To analyze the relationship between the levels of serum total homocysteine(Hcy)with the change in umbilical arterial in the gestational diabetes mellitus.Methods Totally 75 normal late pregnancy(NC group),65 gestational diabetes mellitus pregnancies(GDM group)and 70 pregestational diabetes mellitus(PGDM group)in Hanzhong Central Hospital were recruicted in this study from January 2017 to June 2018.Thelevel of serum homocysteine and the umbilical artery blood flow parameter weredetected.Correlation tests were conducted between these indicators.Results There was no significant difference in the clinical data between the PGDM,GDM and NC group(F=0.559～0.950,all P>0.05).The Hcy expression levels of PGDM,GDM and NC groups were 10.33±1.78,6.78±1.31and 3.89±1.21 μmol/L,respectively.The difference between the groups was statistically significant(F=27.66,P=0.000).The S/D of PGDM,GDM and NC groups were 3.91±0.75,3.22±0.64 and 2.71±0.46,RI were 0.80±0.06,0.63±0.06 and 0.51±0.05,PI were 1.42±0.71,1.12±0.29 and 0.65±0.33,respectively.The difference between the groups were statistically significant(F=6.765,4.398,7.890,P=0.005,0.013,0.002).Hcy of PGDM group was positively correlated with S/D,RI and PI(r=0.801,0.719,0.459,P=0.001,0.002,0.021).And Hcy of GDM group was positively correlated with S/D,RI and PI(r=0.559,0.592,0.311,P=0.008,0.007,0.002).Conclusion The levels of Hcy and S/D were significantly higher with HIP(gestational diabetes mellitus and pregestational diabetes mellitus),andS/D was significantly higher with PGDM.To reduce Hcy level and monitor S/D would be new ways for the treatment of HIP.

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备注/Memo

备注/Memo:
作者简介:吴曼莉(1981-),女,大学本科,主治医师,主要从事产科相关工作,E-mail: 364755326@qq.com。 收稿日期:2019-03-06 修回日期:2019-03-27
更新日期/Last Update: 2019-06-20