[1]陈丽华,朱婕曼,刘玉凤,等.子宫内膜癌组织中血管紧张素~1-7及线粒体组装受体水平表达与临床病理特征的相关性[J].现代检验医学杂志,2021,36(02):24-27.[doi:doi:10.3969/j.issn.1671-7414.2021.02.006]
 CHEN Li-hua,ZHU Jie-man,LIU Yu-feng,et al.Correlation between the Expression of Angiotensin (1-7) and Mitochondrial Assembled Receptors and Clinicopathological Characteristics in Endometrial Cancer[J].Journal of Modern Laboratory Medicine,2021,36(02):24-27.[doi:doi:10.3969/j.issn.1671-7414.2021.02.006]
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子宫内膜癌组织中血管紧张素~1-7及线粒体组装受体水平表达与临床病理特征的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
24-27
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Correlation between the Expression of Angiotensin (1-7) and Mitochondrial Assembled Receptors and Clinicopathological Characteristics in Endometrial Cancer
文章编号:
1671-7414(2021)02-024-04
作者:
陈丽华朱婕曼刘玉凤
(河北北方学院附属第一医院a.妇产科;b.病理科,河北张家口075061)
Author(s):
CHEN Li-huaZHU Jie-man LIU Yu-feng et al
(a. Department of Obstetrics and Gynecdogy; b.Department of Pathdogy, the First Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075000, China)
关键词:
子宫内膜癌血管紧张素(1-7)线粒体组装受体癌细胞组织新生血管
分类号:
R737.33;R730.43
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.006
文献标志码:
A
摘要:
目的 探究血管紧张素(1-7)[angiotensin-(1-7),Ang-(1-7)]及线粒体组装受体(mitochondrial assembly of receptor ,MasR)在子宫内膜癌中的表达及相关性。方法 选取河北北方学院附属第一医院2017年4月~2019年4月治疗的16例正常子宫内膜组织,32例子宫内膜不典型增生组织和78例手术切除的子宫内膜癌组织,共126例。使用酶联免疫吸附法(ELISA)检测Ang-(1-7),Western blot检测MasR在组织中的表达情况。结果 三组组织中,正常子宫内膜组织内Ang-(1-7)(χ2=11.506,P=0.000)和MasR(χ2=8.619,P=0.002)阳性率最低,子宫内膜癌组阳性率最高,差异均具有统计学意义。与另外两组相比,子宫内膜癌组Ang-(1-7)和MasR表达显著增高。Ang-(1-7),MasR表达水平和子宫内膜癌肿瘤分期(t≥2.82,P=0.001)、转移(F=33.35和13.80,P=0.000)及分化程度(t≥2.82,P=0.029)均有相关性。结论 Ang-(1-7)及MasR参与了子宫内膜癌新生血管的生成,其表达增高可促发癌细胞增长,可用于治疗及预后子宫内膜癌的新靶点。

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备注/Memo

备注/Memo:
基金项目:河北省医学科学研究重点课题计划项目(20180836)。作者信息:陈丽华(1986-),女,硕士研究生,主治医师,研究方向:妇产,E-mail: chenlihualyb@163.com。
通讯作者:朱婕曼(1982-),女,研究方向:生殖医学,E-mail: 5436516@qq.com。
更新日期/Last Update: 2021-04-10