[1]李功娟,张治洋,樊阳阳.FEZF1-AS1在子宫内膜癌中的表达及其与患者临床特征的相关性[J].现代检验医学杂志,2021,36(01):77-80.[doi:10.3969/j.issn.1671-7414.2021.01.020]
 LI Gong-juan,ZHANG Zhi-yang,FAN Yang-yang.Expression of FEZF1-AS1 in Endometrial Carcinoma and Its Correlation with Clinical Characteristics of Patients[J].Journal of Modern Laboratory Medicine,2021,36(01):77-80.[doi:10.3969/j.issn.1671-7414.2021.01.020]
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FEZF1-AS1在子宫内膜癌中的表达及其与患者临床特征的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
77-80
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Expression of FEZF1-AS1 in Endometrial Carcinoma and Its Correlation with Clinical Characteristics of Patients
文章编号:
1671-7414(2021)01-077-04
作者:
李功娟张治洋樊阳阳
(1.安康市汉滨区第一人民医院妇科 ,陕西安康 725000;2.安康市人民医院妇科,陕西安康 725000; 3.陕西省人民医院产科,西安 710068)
Author(s):
LI Gong-juan ZHANG Zhi-yang FAN Yang-yang
(1.Department of Gynecology, the First People’s Hospital of Ankang Hanbin District, Shaanxi Ankang 725000, China; 2. Department of Gynaecology, Ankang People’s Hospital, Shaanxi Ankang 725000, China; 3. Department of Obstetrics, Shaanxi Provincial People’s Hospital, Xi’an 710068, China)
关键词:
FEZ家族锌指 1反义 RNA 1子宫内膜癌临床特征相关性
分类号:
R737.33;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.01.020
文献标志码:
A
摘要:
目的 探讨 FEZ家族锌指 1反义 RNA 1(FEZF1-AS1)在子宫内膜癌 (endometrial cancer, EC)中的表达及其与临床病理的相关性。方法 选取 2010年 1月 ~2018年 1月安康市人民医院收治的 172例 EC患者为研究对象,通过实时荧光定量 PCR(quantitative real-time PCR, qPCR)分别检测患者的 EC组织和癌旁正常组织中 FEZF1-AS1的相对表达量,并且分析 FEZF1-AS1表达水平与 EC患者临床特征之间的关系。结果 FEZF1-AS1在 EC组织中的相对表达量显著高于癌旁正常组织 (P=0.007),其表达水平与 EC患者家族肿瘤史 (χ2=6.891,P=0.016)、病理分级 (χ2=7.142,P=0.028)、肿瘤分期 (χ2=10.426,P=0.002)、T分期 (χ2=8.248,P=0.007)和 M分期 (χ2=10.405,P=0.002)显著相关。结论 FEZF1-AS1在 EC中高表达,且其与患者的家族肿瘤史、病理分级和肿瘤分期等相关。

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备注/Memo

备注/Memo:
作者简介:李功娟 (1986-),女,本科,主治医师,研究方向:滋养细胞肿瘤、妇科恶性肿瘤,E-mail:ankangligongj@163.com。
通讯作者:张治洋 (1976-),女,本科,副主任医师,研究方向:宫颈癌、子宫内膜癌、卵巢癌,E-mail:864318979@qq.com。
更新日期/Last Update: 2021-02-05