[1]王 佩,米晓燕,白园园,等.强直性脊柱炎患者血清 YKL-40,Galectin-3 和 ChT 水平与疾病活动度及动脉粥样硬化进展的相关性研究[J].现代检验医学杂志,2021,36(03):52-57.[doi:10.3969/j.issn.1671-7414.2021.03.012]
 WANG Pei,MI Xiao-yan,BAI Yuan-yuan,et al.Correlation of Serum YKL-40, Galectin-3, CHT Levels with Disease Activityand Progression of Atherosclerosis in Patients with Ankylosing Spondylitis[J].Journal of Modern Laboratory Medicine,2021,36(03):52-57.[doi:10.3969/j.issn.1671-7414.2021.03.012]
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强直性脊柱炎患者血清 YKL-40,Galectin-3 和 ChT 水平与疾病活动度及动脉粥样硬化进展的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
52-57
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation of Serum YKL-40, Galectin-3, CHT Levels with Disease Activityand Progression of Atherosclerosis in Patients with Ankylosing Spondylitis
文章编号:
1671-7414(2021)03-052-06
作者:
王 佩米晓燕白园园
(河北省邯郸市中心医院西区免疫科,河北邯郸 056001)
Author(s):
WANG Pei MI Xiao-yan BAI Yuan-yuan ZHOU Hong-min YUE Xiao-lin
(Department of Immunology, West District of Handan Central Hospital, Hebei Handan 056001, China)
关键词:
强直性脊柱炎甲壳质酶蛋白半乳糖凝集素 3几丁质酶疾病活动度动脉粥样硬化
分类号:
R593.23;R392.11;R543.5
DOI:
10.3969/j.issn.1671-7414.2021.03.012
文献标志码:
A
摘要:
目的 探讨强直性脊柱炎(AS)患者血清甲壳质酶蛋白(YKL-40)、半乳糖凝集素3(Galectin-3)和几丁质酶(ChT)水平与疾病活动度及动脉粥样硬化进展的相关性研究。方法 选择 2018 年 3 月 ~2020 年 6 月邯郸市中心医院收治的101 例 AS 患者,分为非活动期组(41 例)和活动期组(60 例),另选择 53 例同期体检健康志愿者为对照组。检测血清 YKL-40,Galectin-3 和 ChT 水平,分析其与 AS 疾病活动度以及颈动脉内 - 中膜厚度(IMT)、颈股脉搏波传导速度(cfPWV)相关性。结果 活动期组血清 YKL-40,Galectin-3 和 ChT 水平高于非活动期组和对照组,差异均有统计学意义(t=6.135,13.787,10.753;11.072,25.964,24.184,均 P < 0.05),非活动期组血清 YKL-40,Galectin-3,ChT水平高于对照组(t=8.016,26.088,23.085,均 P < 0.05)。活动期组 BASDAI 评分、Bath 强直性脊柱炎功能指数(BASFI)评分高于非活动期组(t=13.311,15.236,均 P < 0.05),活动期组 IMT,cfPWV 高于非活动期组和对照组(t=6.243,68.401;13.057,71.880,均 P < 0.05),非活动期组 IMT,cfPWV 高于对照组(t=8.126,12.154,均 P < 0.05),差异均有统计学意义。相关性分析结果显示:AS 患者血清 YKL-40,Galectin-3 和 ChT 水平与 BASDAI 评分,BASFI 评分呈正相关(rs=0.541,0.437;0.423,0.426;0.513,0.406,均 P < 0.05),与 IMT,cfPWV 呈正相关(r=0.501,0.414;0.524,0.509;0.433,0.469,均 P < 0.05)。结论 AS 患者血清 YKL-40,Galectin-3 和 ChT 水平均升高,YKL-40,Galectin-3 和 ChT 升高与 AS 活动和动脉粥样硬化有关。

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备注/Memo

备注/Memo:
基金项目:河北省 2018 年度医学科学研究重点课题计划(201801852)。
作者简介:王佩(1980-),女,本科,主治医师,研究方向:风湿免疫,E-mail:Peiwang0820@163.com。
更新日期/Last Update: 1900-01-01